Publications by authors named "Senxiang Chen"
Osteoporosis is a clinical disease characterized by decreased bone density due to a disrupted balance between bone formation and resorption, which increases fracture risk and negatively affects the quality of life of a patient. LncRNAs are RNA molecules over 200 nucleotides in length with non-coding potential. Many studies have demonstrated that numerous biological processes involved in bone metabolism are affected.
View Article and Find Full Text PDFOsteoarthritis (OA) is a common joint disease, and studies have reported that the endoplasmic reticulum stress (ERS) in chondrocytes caused by the cartilage tissue damage could mediate the activation of Nod-like receptor protein 3 (NLRP3) inflammasomes through inositol-requiring enzyme 1 alpha (IRE1α) and thioredoxin interacting protein (TXNIP). Ginsenoside compound K (CK) has an inhibitory effect on IRE1α activation. However, the role of IRE1α-TXNIP and its interaction with CK are still unclear.
View Article and Find Full Text PDFOsteoblast proliferation and osteogenic differentiation (OGD) are regulated by complex mechanisms. The roles in cell proliferation and OGD of RNA-binding proteins in the insulin-like growth factor 2 mRNA-binding protein (IGF2BP) family remain unclear. To elucidate this, we examined the differential expression of IGF2BP2 in OGD and osteoporosis, and the expression profile of IGF2BP2-binding RNA in vitro.
View Article and Find Full Text PDFUbiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) can mediate DNA methylation and histone modifications in the epigenetic regulation of gene expression, stem cell differentiation and tumorigenesis. Here, we analyzed the differentially expressed mRNAs (DEmRNAs) in osteogenesis differentiation of MSCs and osteosarcoma. We identified UHRF1 as the co-DEmRNA to regulate the osteogenesis differentiation of MSCs and osteosarcoma.
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- Lung adenocarcinoma (LUAD) is a prevalent and serious type of lung cancer, and this study focuses on the role of IGF2BPs, proteins that promote LUAD progression but whose expression and prognostic value are not well understood.
- The researchers analyzed patient data from databases to assess IGF2BP expression and its correlation with survival outcomes, finding that high levels of IGF2BPs are linked to poorer overall survival.
- Additionally, the study identified genetic mutations related to IGF2BPs and their connections to other genes, offering insights into potential therapeutic targets and the biological mechanisms involved in LUAD.
Article Synopsis
- Long noncoding RNAs (lncRNAs) are significant regulators in human cells, influencing functions and processes that can lead to various diseases, including cancer and bone disorders.
- The lncRNA growth arrest-specific 5 (GAS5) has been identified as crucial in regulating cell growth and differentiation, linking it to the development of bone diseases like osteoporosis and osteosarcoma.
- The review highlights recent findings on GAS5's role in bone diseases, aiming to uncover new therapeutic targets for treatment.
Article Synopsis
- Osteoporosis is a common and serious bone disease, making research into its molecular mechanisms and treatments essential for global health.
- Long non-coding RNA (lncRNA), particularly H19, has been found to significantly influence various biological functions and plays a role in regulating bone cells involved in osteoporosis.
- Targeting lncRNA H19 presents a promising new avenue for osteoporosis treatment, with ongoing research exploring its molecular pathways and potential as a therapeutic target for improving bone health.