Publications by authors named "Senthilkumaran S"

Introduction: Snakebite envenoming is a multidimensional issue that causes severe functional and life-challenging consequences among rural communities in tropical countries. Current research and treatments are largely focused on the acute effects of envenomation and short-term health outcomes. The knowledge of snakebite-induced long-term consequences is highly limited.

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  • The study investigates snake phobia in India, highlighting its evolutionary roots and the importance of understanding this fear in the context of preventing snakebites, which lead to significant health issues and socioeconomic impacts in the region.
  • Researchers modified an existing snake phobia assessment tool (SNAQ12) and validated it in English and Tamil, collecting responses from over 2,000 individuals to analyze the prevalence and characteristics of snake phobia among the population.
  • Findings indicate that males exhibit higher levels of snake phobia across all age groups compared to females in India, challenging previous assumptions that women typically experience greater phobia levels; no other significant factors were found to influence this phobia.
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Envenomings from Russell's viper typically result in local tissue damage and bleeding complications, but the bites from common krait and cobra primarily cause neurotoxic effects. While most symptoms can be treated with appropriate antivenom, additional support is necessary for several snakebite victims to tackle a broad range of unusual complications that they develop following bites. Reversible vasoconstriction syndrome (RCVS), characterised by the constriction of cerebral arteries, is a rare but serious issue, presenting with severe headaches and, in extreme cases, haemorrhagic/ischaemic stroke.

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  • Human-snake conflicts lead to significant health issues, including over 125,000 deaths and 400,000 disabilities annually, with India alone experiencing about 58,000 snakebite deaths each year.
  • Volunteer snake rescuers play an essential role in relocating snakes but often lack formal training and funds for equipment, exposing them to serious risks during rescues.
  • The study emphasizes the need for structured training and better support for snake rescuers to enhance safety for both the individuals and the snakes they handle.*
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Venom-induced consumption coagulopathy (VICC) is a common complication of snakebite that is associated with hypofibrinogenemia, bleeding, disability, and death. In remote tropical settings, where most snakebites occur, the 20-minute whole blood clotting test is used to diagnose VICC. Point-of-care (POC) coagulation devices could provide an accessible means of detecting VICC that is better standardized, quantifiable, and more accurate.

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Background: The present study, plant extract to biosynthesize silver nanoparticles (AgNPs), is an environmentally benign way to lessen the use of dangerous chemicals.

Aims And Objectives: The antibacterial effects of the green production of AgNPs by extract were examined.

Materials And Methods: Utilizing scanning, transmission electron microscopy, X-ray diffraction (XRD), ultraviolet-visible spectroscopy, and infrared spectroscopy, researchers examined the physical and chemical characteristics of synthesized AgNPs.

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Snakebite envenoming and its resulting complications are serious threats to the health of vulnerable people living in rural areas of developing countries. The knowledge of the heterogeneity of symptoms associated with snakebite envenoming and their management strategies is vital to treat such life-threatening complications to save lives. Russell's viper envenomation induces a diverse range of clinical manifestations from commonly recognised haemotoxic and local effects to several rare conditions that are often not reported.

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  • Local tissue damage from snakebite envenoming is not well studied, yet understanding venom toxins' effects is key for improving treatment strategies.
  • Research using myoblast cell lines shows that Russell's viper venom decreases cell viability, migration, and promotes muscle atrophy, while cobra venom also reduces viability but less significantly affects other factors.
  • Antivenom against the 'Big Four' Indian snakes mitigates cobra venom effects, while Russell's viper venom-induced damage can be rescued by certain inhibitors; further research is needed to clarify the mechanisms behind these venom effects and enhance treatment options.
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Background: India suffers ~58,000 annual deaths due to snakebites. The 'Big Four' snakes (Russell's viper, Indian cobra, common krait, and saw-scaled viper) that are responsible for most bites cause diverse clinical effects. Delayed treatment increases the risk of serious complications and treatment costs.

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Snakebite envenoming (SBE) is common in rural communities living in tropical regions that often have fragile and/or overwhelmed healthcare systems. The complex scenarios around SBE lead to a high number of deaths, disabilities, and long-term consequences in patients. Russell's viper (Daboia russelii) is one of the most medically important snake species in India, which causes devastating pathological conditions characterised by a wide range of clinical manifestations.

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  • Lip, oral, and pharyngeal cancers pose significant global health challenges, making it essential to analyze their burden for effective health policies.
  • The study utilized data from the 2019 Global Burden of Diseases, Injuries, and Risk Factors Study to assess cancer incidence, mortality, and life years lost across 204 countries, linking these to socio-demographic factors.
  • Findings revealed approximately 370,000 cases and 199,000 deaths for lip and oral cavity cancer, and 167,000 cases and 114,000 deaths for other pharyngeal cancers in 2019, with smoking being the leading risk factor for these cancers, especially in low and middle SDI regions.
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Envenomings by Russell's viper ( ), a species of high medical importance in India and other Asian countries, commonly result in hemorrhage, coagulopathies, necrosis, and acute kidney injury. Although bleeding complications are frequently reported following viper envenomings, thrombotic events occur rarely (reported only in coronary and carotid arteries) with serious consequences. For the first time, we report three serious cases of peripheral arterial thrombosis following Russell's viper bites and their diagnostic, clinical management, and mechanistic insights.

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With the continued growth of human populations, rural urbanisation and habitat degradation are on the rise, resulting in the displacement of native wildlife and an increase in human-wildlife conflicts. The presence of human habitation and waste often attracts rodents and thereby, snakes, leading to increased snake sightings in homes. To address this problem, snake handlers, who are volunteers that remove and relocate snakes away from human development areas, are called upon.

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Snakebite envenomation is regarded as a high-priority neglected tropical disease by the World Health Organisation, as it results in significant loss of lives and permanent disabilities. Russell's viper is one of the important venomous snakes that causes morbidities, mortalities and disabilities in India. The clinical presentation of Russell's viper envenomation is characterised by local envenoming effects including tissue damage, venom-induced coagulopathy, neurotoxicity, and kidney injury.

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Snakebite envenomation (SBE) is a life-threatening medical emergency with a high mortality rate. Common secondary complications following SBE, such as wound infections, are significant due to their impact on worsening local tissue damage and causing systemic infection. Antivenoms are not effective to treat wound infections following SBE.

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Article Synopsis
  • Snakebite envenomation (SBE) management is tough in developing tropical regions due to complex symptoms and poor medical resources, with some snakes like the Indian Russell's viper causing rare complications.
  • A case is discussed where a patient bitten by a Russell's viper experienced serious issues like adrenal and pituitary hemorrhages, despite receiving antivenom and other treatments.
  • The patient ultimately recovered after receiving hydrocortisone and thyroxine, highlighting the need for better awareness and treatment strategies for rare complications of snakebites.
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Snakebite envenomation causes systemic and local manifestations, which result from the individual or synergistic actions of multiple venom components. The pathological hallmarks of medically important venomous snakes such as the Indian Russell's viper (Daboia russelii) are well known. Envenomation by Russell's viper is typically characterised by coagulopathies, muscular damage, nephrotoxicity, and neurotoxicity.

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Snakebite envenoming (SBE) predominantly affects rural impoverished communities that have limited access to immediate healthcare. These communities often hold numerous myths/misbeliefs about snakes and SBE. Moreover, healthcare professionals who practice in rural regions often work in unstable situations with limited medical infrastructure and therefore, lack sufficient knowledge/experience and confidence in the clinical management of SBE.

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India suffers the highest incidence of snakebite envenomation (SBE) in the world. Rural communities within India and other countries have long-held cultural beliefs surrounding snakes and SBE treatments, with snake statues present in numerous Hindu temples. While most cultural beliefs are well respected and do not affect anyone, some people worship live venomous snakes without any safety precautions.

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