Publications by authors named "Senna Staessens"
Article Synopsis
- Achieving first-pass recanalization (FPR) during thrombectomy is crucial for better clinical outcomes in acute ischemic stroke patients, making it important to understand the factors that cause FPR failures.
- This study examined the relationship between thrombus composition and the success rates of FPR by analyzing thrombi from 267 stroke patients.
- Results showed that thrombi leading to successful FPR had more red blood cells and less fibrin and extracellular DNA, suggesting that certain thrombus characteristics can influence the likelihood of achieving FPR.
Article Synopsis
- Researchers studied how the composition of blood clots (thrombi) affects their breakdown by r-tPA, a treatment for acute ischemic stroke.
- They found that thrombi with more red blood cells are easier to dissolve than those with higher levels of DNA and von Willebrand Factor.
- Adding DNase-1 or N,N'-diacetyl-l-cystine to r-tPA treatments significantly improved the breakdown of harder-to-treat thrombi.
Article Synopsis
- - The study investigated the use of electrochemical impedance spectroscopy (EIS) combined with machine learning to analyze thrombi collected during mechanical thrombectomy (MT) for strokes, focusing on predicting red blood cell (RBC) content.
- - Researchers conducted a multicentric feasibility study, analyzing 179 thrombi and comparing EIS results with histological data, finding a strong correlation and validating EIS's predictive ability for RBC composition.
- - The method showed promising results, with sensitivity for classifying thrombi as "RBC-rich" or "RBC-poor" ranging from 77% to 85% and specificity from 72% to 88%, suggesting it could enhance strategies for stroke treatment.
Objectives: Intra-device thrombosis remains one of the most common complications during extracorporeal membrane oxygenation (ECMO). Despite anticoagulation, approximately 35% of patients develop thrombi in the membrane oxygenator, pump heads, or tubing. The aim of this study was to describe the molecular and cellular features of ECMO thrombi and to study the main drivers of thrombus formation at different sites in the ECMO circuits.
View Article and Find Full Text PDFBackground: Several studies have investigated the histopathology of mechanically retrieved thrombi from stroke patients. Thrombi with unusual components constitute about 1-2% of all stroke thrombi in clinical practice. Knowledge about these rare components is limited.
View Article and Find Full Text PDFArticle Synopsis
- - The study of ischemic stroke thrombi has become important, particularly with the rise of endovascular procedures, allowing researchers to analyze the actual thrombus material from patients.
- - Stroke thrombi are complex and made up of various biochemical and cellular elements, which may pose challenges in treatment but also provide new insights into stroke management.
- - Understanding the characteristics of thrombus composition could improve outcomes in stroke treatment, including the success of thrombectomy procedures and overall patient care.
Vascular Endothelial Damage in the Pathogenesis of Organ Injury in Severe COVID-19.
Arterioscler Thromb Vasc Biol
May 2021
[Figure: see text].
View Article and Find Full Text PDFBackground: Mechanical removal of a thrombus by thrombectomy can be quite challenging. For reasons that are not fully understood, some thrombi require multiple passes to achieve successful recanalization, whereas other thrombi are efficiently removed in a single pass. Since first pass success is associated with better clinical outcome, it is important to better understand the nature of thrombectomy resistant thrombi.
View Article and Find Full Text PDFThe structure of stroke thrombi has gained an increasing amount of interest in recent years. The advent of endovascular thrombectomy has offered the unique opportunity to provide and analyze thrombi removed from ischemic stroke patients. It has become clear that the composition of ischemic stroke thrombi is relatively heterogenous and various molecular and cellular patterns become apparent.
View Article and Find Full Text PDFIschemic stroke is caused by a thromboembolic occlusion of cerebral arteries. Treatment is focused on fast and efficient removal of the occluding thrombus, either intravenous thrombolysis or endovascular thrombectomy. Recanalization, however, is not always successful and factors contributing to failure are not completely understood.
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