An unresectable and metastatic intrahepatic cholangiocarcinoma with EML4-ALK rearrangement achieving partial response after first-line treatment with ensartinib: a case report.

Systemic chemotherapies are the primary treatment options for patients with unresectable and metastatic intrahepatic cholangiocarcinoma (ICC), but the effectiveness of current systemic therapies is limited. The development of targeted-therapy has changed the treatment landscape of ICC, and comprehensive genome sequencing of advanced cholangiocarcinoma patients could be beneficial to identify potential targets to guide individualized treatment. Herein, we reported an unresectable and metastatic ICC patient who detected EML4-ALK rearrangement in peripheral blood, which was later confirmed on tissue-based testing, and achieved partial response (PR) after first-line treatment with ensartinib.

Comparison of hydrochloric acid infusion radiofrequency ablation with microwave ablation in an ex vivo liver model.

To compare sizes and shapes of ablation zones resulting from hydrochloric acid infusion radiofrequency ablation (HRFA) and microwave ablation (MWA), using normal saline infusion radiofrequency ablation (NSRFA) as a control, at a variety of matched power settings and ablation durations, in an bovine liver model. A total of 90 ablation procedures were performed, using each of three modalities: NSRFA, HRFA, and MWA. For each modality, five ablation procedures were performed for each combination of power (80 W, 100 W, or 120 W) and duration (5, 10, 20, 30, 45, or 60 min).

Sequential and Simultaneous 4-Antenna Microwave Ablation in an Ex Vivo Bovine Liver Model.

Aims: To determine the sizes and shapes of ablation zones in 4-antenna microwave ablation in ex vivo bovine liver model under different conditions of power delivery patterns, antenna spacings, and ablation durations, for further using of multi-antenna MWA strategies in the treatment of large hepatocellular carcinoma.

Methods: We tested protocols of eight ablations each on ex vivo bovine livers, involving simultaneous or sequential activation of four microwave antennas, spaced either 3 cm, 4 cm, or 5 cm apart, for either 10 or 15 min, at 60-W power. We determined the diameters, shapes, and temperatures of the ablation zones.

Does the Site of the Primary Affect Outcomes When Ablating Colorectal Liver Metastases with Radiofrequency Ablation?

Purpose: To determine whether primary tumor side was a predictor of radiofrequency ablation (RFA) outcome in colorectal liver metastases (CRLM).

Materials And Methods: The institutional review board approved this retrospective study. Written informed consent was obtained from all patients.

Safety and effect on ablation size of hydrochloric acid-perfused radiofrequency ablation in animal livers.

Purpose: Our objective was to determine the safety and ablation size of hydrochloric acid-perfused radiofrequency ablation (HCl-RFA) in liver tissues, prospectively using in vivo rabbit and ex vivo porcine liver models.

Materials And Methods: The livers in 30 rabbits were treated in vivo with perfusions of normal saline (controls) and HCl concentrations of 5%, 10%, 15%, and 20%, during RFA at 103 °C and 30 W for 3 min. For each experimental setting, six ablations were created.

[Analyze the factors influencing multi-electrode synchronous radiofrequency ablation via switching controller in ex vivo bovine liver].

Objective: To investigate the effects of different electrode exposed end and different ablated time on lesion size of Cool-tip multi-electrode synchronous radiofrequency ablation via switching controller in ex vivo bovine liver.

Method: Twelve combinations of different electrode exposed end (2 cm, 3 cm and 4 cm) were used, and different ablated time (12, 16, 20 and 24 mins) was as experimental parameter. Ablated lesions in longitudinal diameter, transverse diameter and volume were measured.

[Effect analysis of multi-electrode synchronous radiofrequency ablation and conventional single electrode overlapping ablation].

Objective: To explore the different effects in ex vivo bovine liver between multiple cool-tip internally cooled electrodes synchronous radiofrequency ablation via switching controller and conventional single electrode overlapping radiofrequency ablation.

Method: The above two methods were used to ablate in ex vivo bovine liver respectively. Electrode exposed end was 3 cm or 4 cm in length.