Publications by authors named "Senlin Liao"
Cyclophosphamide (CP) is a widely used chemotherapeutic drug and immunosuppressant in the clinic, and the hypoandrogenism caused by CP is receiving more attention. Some studies found that ferroptosis is a new mechanism of cell death closely related to chemotherapeutic drugs and plays a key role in regulating reproductive injuries. The purpose of this study is to explore ferroptosis' role in testicular Leydig cell dysfunction and molecular mechanisms relating to it.
View Article and Find Full Text PDFCyclophosphamide-induced testosterone deficiency (CPTD) during the treatment of cancers and autoimmune disorders severely influences the quality of life of patients. Currently, several guidelines recommend patients suffering from CPTD receive testosterone replacement therapy (TRT). However, TRT has many disadvantages underscoring the requirement for alternative, nontoxic treatment strategies.
View Article and Find Full Text PDFArticle Synopsis
- Scientists wanted to see how tiny particles called exosomes from special cells (BMSCs) could help injured cells (TM3 Leydig cells) affected by a drug called cyclophosphamide (CP).
- They tested the exosomes by mixing them with the injured cells and measuring how healthy the cells were, along with tracking levels of testosterone, a hormone.
- The results showed that the exosomes helped the injured cells become healthier again and raised the testosterone levels compared to the injured cells alone.