Multi-objective optimization of Stinger PDC cutter breaking rock parameters under intrusion-cutting action using Taguchi-based gray relational analysis.

To enhance the efficiency of the Stinger Polycrystalline Diamond Compact (PDC) cutter in breaking hard rocks, this study focuses on optimizing the cutter intrusion-cutting rock breaking parameters. A numerical calculation model for the rotational breaking of granite by a Stinger PDC cutter was established. A comprehensive statistical examination was performed to assess the influence of various factors on intrusion ability (IA), tangential force (TF), and mechanical specific energy (MSE).

Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways.

Shikonin, a botanical drug extracted from Lithospermum erythrorhizon, exhibits anti-cancer effects in various cancer cell lines. However, the mechanisms underlying these effects have not been completely elucidated yet. Here, we showed that Shikonin induces apoptosis and autophagy in A375 cells and inhibits their proliferation.