One-pot multicomponent reaction: An efficient synthesis of 4-(HET)Aryl-substituted pyrazolo-quinolinones.

Introduction: Pyrazolo-quinolinones (PQs) are a versatile class of Organic chemistry and it was found that they have very advanced functionally promising as selective compounds due to their scaffold and demonstrated low toxicity and considerable clinical promise. Moreover, these compounds have an important role in different applications such as analytical reagents, technical, pharmaceutical development, and biological markers. So, we aimed to synthesize and characterize new 4-(Het)aryl-substituted Pyrazole-quinolinones.

Synthesis and Structure of Hetaryl Substituted 2,5-dioxo-1,2,3,4,5,6,7,8- Octahydroquinolines.

Aims And Objective: Condensation of 5-hetarylidene-2,2-dimethyl-1,3-dioxane-4,6- diones with 5,5-dimethyl-3-arylamino-2-cyclohexanones yields 1-aryl-4-hetaryl-7,7-dimethyl-2,5- dioxo-l,2,3,4,5,5,7,8-octahydro-quinolines. The structures of all the synthesized compounds have been verified by IR, 1H-NMR, 13C-NMR, and mass spectral methods. The 13C-NMR assignments were supported by HSQC and HMBC experiments.

Kinetic and in silico analysis of thiazolidin-based inhibitors of α-carbonic anhydrase isoenzymes.

Carbonic anhydrases (CAs, EC 4.2.1.

2-[(E)-4-Quinolylmethyl-ideneamino]-phenol.

In the title compound, C(16)H(12)N(2)O, the dihedral angle between the two aromatic ring systems is 68.54 (5)°. The mol-ecular packing is stabilized by intra- and inter-molecular O-H⋯N and intra-molecular C-H⋯N hydrogen-bond inter-actions.