Publications by authors named "Seniz Inanc Surer"
Article Synopsis
- Collagenases, a type of matrix metalloproteinase, are key in cancer invasion and metastasis, but traditional analysis methods struggle with accurately measuring their activity in vitro.
- Researchers developed a new technique called "cell in situ collagen zymography" to improve the study of local collagenase activities, using various human thyroid cancer cell lines.
- The optimized technique demonstrated that a "sandwich model" with specific dye-quenched collagen and fixation methods effectively visualizes collagenase activity, and it proved to be applicable across different thyroid cell lines, offering a fast and affordable approach for analysis.
Tetracaine, a long-acting amino ester-type local anesthetic, prevents the initiation and propagation of action potentials by reversibly blocking voltage-gated sodium channels (VGSCs). These channels, which are highly expressed in several carcinomas (e.g.
View Article and Find Full Text PDFBackground: Nanomedicine has provided promising tools for the imaging, diagnosis, and treatment of cancer. Gold nanoparticles (GNPs) may be useful in enhancing the efficacy of radiotherapy, such as radiosensitization, in cancer therapy.
Aims: To develop a nanodrug complex containing cetuximab (C225,CTX) and cisplatin (CDDP) conjugated with GNPs and to investigate its cytotoxic effects on oral cavity cancer cells when combined with radiotherapy.