Publications by authors named "Seng Manivong"

Article Synopsis
  • Osteoarthritis is a major issue for athletic horses, causing pain and leading to early retirement, with hydro-expansive functionalized nanogels being explored as a potential treatment through a double-blinded randomized tolerance study.
  • Eight healthy horses received injections of chitosan and hyaluronic acid nanogels and saline as controls, monitored for clinical signs and synovial fluid changes over three months.
  • The study found mild synovitis in the treated group following injections, which resolved quickly, and while inflammation markers showed a temporary rise, there were no long-term adverse effects, indicating the treatment could be safe.
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The burden of osteoarthritis (OA), one of the major causes of functional disabilities in humans and animals, continues to increase worldwide while no disease-modifying OA drugs (DMOADs) that either slow down or reverse disease progression have been made available. Here, we provide a brief overview of recent advances in: designing new OA drug delivery approaches, focusing on lubrication-based biomaterials and drug delivery systems, such as hydrogels, liposomes, dendrimers, micro- and nanoparticles; using either large (horse) or small (zebrafish) relevant animal models to evaluate new therapeutic strategies; and OA in vitro modeling, focusing on 3D (organoid) models of cartilage regarding the Replace, Reduce and Refine (3R) principle of animal experimentation.

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Osteoarthritis (OA) is a degenerative and heterogeneous disease that affects all types of joint structures. Current clinical treatments are only symptomatic and do not manage the degenerative process in animals or humans. One of the new orthobiological treatment strategies being developed to treat OA is the use of drug delivery systems (DDS) to release bioactive molecules over a long period of time directly into the joint to limit inflammation, control pain, and reduce cartilage degradation.

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One important challenge in treating avascular-degraded cartilage is the development of new drugs for both pain management and joint preservation. Considerable efforts have been invested in developing nanosystems using biomaterials, such as chitosan, a widely used natural polymer exhibiting numerous advantages, i.e.

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