Publications by authors named "Seng Kar Yap"
Article Synopsis
- Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (hUC-MSCs-sEVs) have shown potential in treating diabetes, but previous dosages used in animal studies were too high for human application.
- This study evaluated the effects of lower doses of hUC-MSCs-sEVs on human skeletal muscle cells and type 2 diabetes mellitus (T2DM) rats, finding no significant cytotoxicity at 100 μg/mL and an 80-90% increase in glucose uptake at 20 μg/mL.
- The treatment improved glucose tolerance and had protective effects on blood count, while also demonstrating no significant harm to liver and kidney functions, indicating that hUC-M
serotype B:2 causes hemorrhagic septicemia in cattle and buffalo. The invasion mechanism of the bacterium when invading the bloodstream is unclear. This study aimed to characterize the effects of immunomodulatory molecules, namely dexamethasone and lipopolysaccharide, on the invasion efficiency of serotype B:2 toward bovine aortic endothelial cells (BAECs) and the involvement of actin microfilaments in the invasion mechanism.
View Article and Find Full Text PDF