Publications by authors named "Sener H"
Clinical Relevance: Endonasal dacryocystorhinostomy (EN-DCR) is one of the preferred interventions for occlusion of the nasolacrimal drainage system. Understanding the bulbar conjunctival changes that occur after EN-DCR surgery will provide better insight into the effect of this procedure on visual quality and patient comfort.
Background: This study aimed to evaluate visual quality and bulbar conjunctival cytologic changes using in vivo confocal microscopy and corneal topography in patients with epiphora resulting from nasolacrimal duct obstruction after EN-DCR.
Purpose: To determine the impact of uveal melanoma thickness on patient survival from the date of presentation and at specific time intervals following metastasis-free survival.
Methods: In this retrospective cohort study, we evaluated data from 8034 consecutive uveal melanoma patients diagnosed at a tertiary care ocular oncology center between May 1972 and August 2007. The patients were categorized on the basis of tumor thickness (per each 1-mm increment) and evaluated for non-conditional survival (from date of presentation) and conditional survival (with 3-years, 5-years, and 10-years of metastasis-free survival) on the cumulative incidence of melanoma-related metastasis at 5-, 10-, 15-, 20-, 25- and 30-years.
Article Synopsis
- The study aimed to assess the choroidal vascular parameters in keratoconus (KC) patients and their relationship to eye topography.
- Researchers analyzed 90 KC patients grouped by severity and compared them to 29 patients without KC, focusing on choroidal microvascular density and vascularity indices.
- Results indicated a decrease in specific retinal nerve fiber thickness and choroidal vascularity in advanced KC patients, along with a weak negative correlation between choroidal vascularity and keratometry measurements.
Background: Uveal melanoma (UM) can be classified by tumour size category and by The Cancer Genome Atlas (TCGA) groups (cytogenetic-based, 4-category prognostic classification into Groups A-D). This study was conducted to assess impact on metastasis-free survival (MFS) in UM by tumour size category based on correlation with TCGA classification.
Methods: Retrospective analysis of 1001 cases categorised as small (0.
Background/aim: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Several studies have shown that alterations of microbiota increase the risk of neurodegenerative disorders. We aimed to reveal whether there is a difference in the gut microbiota of patients with ALS.
View Article and Find Full Text PDFBACKGROUND The BrainLab VectorVision neuronavigation system is an image-guided, frameless localization system used intraoperatively, which includes a computer workstation for viewing and analyzing operative microscopic images. This retrospective study aimed to evaluate the use of the BrainLab VectorVision infrared-based neuronavigation imaging system in 80 patients with intracranial meningioma removed surgically between 2013 and 2023. MATERIAL AND METHODS Data were retrospectively collected from 36 patients with convexity meningioma and 44 patients with parasagittal meningioma between 2013 and 2023.
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- The study aimed to explore changes in the peripapillary choroidal vascular structure in patients with thyroid orbitopathy (TO), comparing those with active and inactive forms of the condition to healthy controls.
- It found significant reductions in various choroidal vascular indices in both active and inactive TO patients compared to controls, particularly noted in the nasal and temporal areas.
- The findings suggest that the horizontal areas of the choroidal structure are more sensitive indicators of changes due to TO, with the inferior quadrant being the first affected in active cases.
Purpose To determine the etiology and anatomic localization of uveitis, the frequency of intraocular pressure (IOP) elevation, and the type of secondary glaucoma and to assess the medical, surgical, and postoperative complications in adult and pediatric patients with acute or chronic uveitis. Methods A total of 307 eyes of 186 patients who were followed up in the Uvea-Behçet Unit of the Ophthalmology Department, Erciyes University, Turkey, were included in the study. Demographic, ocular, and systemic data were recorded; ophthalmological examinations were performed; and recurrences and complications of uveitis were identified.
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- The study aimed to analyze corneal nerve changes and neuropathy in type 2 diabetes patients, categorized by their diabetic retinopathy status.
- A total of 87 diabetic eyes were compared with 28 healthy eyes, measuring various ocular health indicators using in vivo confocal microscopy (IVCM).
- Results indicated that diabetic patients experienced increased ocular surface issues and decreased corneal sensitivity and nerve density as diabetic retinopathy progressed.
Article Synopsis
- The study aimed to assess how adalimumab (ADA) impacts choroidal thickness (ChT) and the choroidal vascularity index (CVI) in patients with non-infectious uveitis (NIU).
- It involved comparing results from 37 NIU eyes, 38 eyes from non-uveitic (NU) patients, and 40 healthy eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) to monitor changes over time.
- Results showed NIU eyes had significantly lower CVI values compared to NU and control eyes, indicating systemic inflammation affects choroidal blood flow, but CVI didn't change with ADA therapy, suggesting it's not a reliable biomarker for treatment monitoring in NI
Article Synopsis
- The study aims to compare the vascular properties of optic discs in patients with crowded discs versus control subjects using optical coherence tomography angiography (OCT-A).
- Thirty patients with crowded discs and 47 control subjects were included, with various measurements taken from the optic discs, including RPC density and pRNFL thickness.
- Results showed that while some measurements were similar, crowded optic discs had a higher RPC density inside the disc and lower PPCMv density in the inner-hemisuperior region.
Article Synopsis
- The study aimed to examine the superficial and deep vascular characteristics of the optic disc in patients with retrobulbar optic neuritis using optical coherence tomography angiography (OCT-A).
- Nineteen patients with unilateral non-infectious retrobulbar neuritis were analyzed, comparing the affected eyes to healthy contralateral eyes, with various optic nerve parameters assessed through OCT-A.
- Results showed significant decreases in certain superficial capillary densities in eyes with optic neuritis, while other parameters such as PPCMv density remained unchanged.
Article Synopsis
- * Results showed decreased peripapillary vascular density and lamina cribrosa thickness (LCT) in TO patients, particularly those with dysthyroid optic neuropathy (DON), but retinal nerve fiber layer thickness (RNFLT) did not show significant differences among groups.
- * IV MTP treatment improved LCT and best-corrected visual acuity in patients, while other measured factors like intraocular pressure and proptosis also decreased, suggesting beneficial effects of the treatment
Objectives: The primary objective of this study was to evaluate the agreement of visual acuity (VA) obtained with the sweep visual evoked potential (sVEP) method with the VA obtained with the Snellen chart. The secondary objective was to examine the effect of age and gender on agreement.
Materials And Methods: Best corrected VAs of subjects were recorded with the Snellen chart, and sVEP testing was performed according to the recommendations of the International Society for Clinical Electrophysiology of Vision (ISCEV).
This study aimed to investigate the protective effect of melatonin against the acute toxicity of cisplatin in ocular tissues. The eyes of 40 rats were divided into 4 groups: Control group (10 rats), Melatonin (Mel) group (10 rats), Cisplatin (Cis) group (10 rats), Melatonin (Mel) + Cisplatin (Cis) group (10 rats). Retina, cornea, and ciliary body tissues were examined after hematoxylin-eosin staining of sections obtained from the eyes and were scored for disorganization and degeneration.
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- The study aimed to examine changes in the choroid of patients with ocular and non-ocular Behçet disease using measures like choroidal vascularity index (CVI) and choroidal thickness (ChT).
- A total of 148 participants were evaluated, including 68 patients with ocular Behçet disease, 40 with non-ocular Behçet disease, and 40 healthy individuals, with results showing significant decreases in ChT in both types of Behçet disease compared to the controls.
- Findings suggest that ocular Behçet disease impacts choroidal vasculature due to uveitis, while systemic inflammation in non-ocular cases does not, indicating that ChT and CVI could serve as potential
Purpose: The purpose of the study was to investigate the parapapillary choroidal microvasculature in thyroid eye disease (TED) using optical coherence tomography angiography (OCTA).
Methods: Only one eye of each subject was included in the study. Patients with TED and controls were included in the study.
Introduction: Restless legs syndrome (RLS) is a sensorimotor condition characterized by disturbing sensations and the desire to move, often localized in the legs. Cognitive changes and impulsivity can be present in RLS, although the potential effect of commonly co-occurring attention-deficit/hyperactivity disorders (ADHD) or dopamine agonist (DA) use on these are unclear.
Method: Twenty-three RLS patients and 22 healthy controls were included.
Article Synopsis
- A new algorithmic "naming-meshing" system was developed to help ophthalmologists distinguish between hypopyon and pseudohypopyon for quicker diagnosis and treatment of anterior chamber sediment.
- A literature review was conducted focusing on strategies for both ophthalmologists and non-ophthalmologists to accurately identify and manage cases of these conditions.
- The study examined various sediment characteristics (like shape, location, and color) and associated clinical findings to better guide diagnosis, emphasizing the importance of understanding these features, especially since the conditions mainly affect younger patients.
Article Synopsis
- The study assessed the effectiveness and safety of adalimumab (ADA) in treating non-infectious uveitis (NIU) that isn't responsive to standard medications.
- A total of 24 patients, primarily with ocular Behçet syndrome, received varying doses of ADA and were evaluated for improvements in vision and inflammation at multiple time points over 24 weeks.
- Results showed significant improvements in visual acuity, inflammation metrics, and macular thickness without any serious side effects, indicating ADA's potential as a preferred treatment option for NIU in young patients.
Background: We investigated whether the photopic negative response (PhNR) in the electroretinogram (ERG) was affected in Parkinson's disease (PD) patients and whether it was associated with retinal changes on optical coherence tomography (OCT).
Methods: Thirty-two patients with PD and 31 age and sex-matched healthy controls from a single tertiary centre were included in the study. Hoehn and Yahr scale scores and the presence of REM sleep behaviour were recorded.
Purpose: To evaluate the incidence of optic cracks and/or fractures during foldable acrylic intraocular lens (IOL) implantation via the manual Monarch delivery system with the cartridge and to determine factors that help to avoid such complications.
Methods: Small-incision phacoemulsification surgery was performed in 702 eyes with visually significant cataract formation. A foldable acrylic soft IOL (AcrySof MA60BM/MA30BA, Alcon, Fort Worth, TX, USA) or a single-piece acrylic soft IOL (Acriva BB, VSY Biotechnology, Amsterdam, The Netherlands) was inserted in all eyes using a cartridge and viscoelastic agents (sodium hyaluronate, Healon, Advanced Medical Optics, Santa Ana, CA, USA).
Objective: To compare the intraocular pressure (IOP)-lowering effect of different types of surgery available in the literature using a network meta-analysis (NMA) based on a systematic review.
Methods: PubMed and the Cochrane database were searched. Randomized clinical trials involving surgical interventions for high IOP for PAC (primary angle closure) or PACG (primary angle closure glaucoma) were included.
Success rate of external, endonasal, and transcanalicular laser DCR with or without silicone stent intubation for NLD obstruction: a network meta-analysis of randomized controlled trials.
Graefes Arch Clin Exp Ophthalmol
December 2023
Purpose: To define and compare the effectiveness of external dacryocystorhinostomy (EX-DCR), endonasal (EN-DCR), and transcanalicular laser-assisted (TL-DCR) with or without silicone stent (S) intubation.
Methods: Studies were retrieved from PubMed, Scopus, and WoS. Frequentist and Bayesian network meta-analyses were performed and pooled estimations were expressed as risk ratio (RR).