Publications by authors named "Senem Cakır"
Although our understanding of herpes simplex virus type 1 (HSV-1) biology has been considerably enhanced, developing therapeutic strategies to eliminate HSV-1 in latently infected individuals remains a public health concern. Current antiviral drugs used for the treatment of HSV-1 complications are not specific and do not address latent infection. We recently developed a CRISPR-Cas9-based gene editing platform to specifically target the HSV-1 genome.
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- * Research into HIV's effects on the brain is hindered by a lack of suitable models; however, recent advances in using induced pluripotent stem cells (iPSCs) and 3D brain organoid systems show promise for studying HIV's interactions with the central nervous system.
- * In this study, human cerebral organoids (hCOs) were created from healthy iPSCs and demonstrated productive HIV-1 infection, while also showing that cART effectively reduces viral replication and gene activity, highlighting
Progress in stem cell research has revolutionized the medical field for more than two decades. More recently, the discovery of induced pluripotent stem cells (iPSCs) has allowed for the development of advanced disease modeling and tissue engineering platforms. iPSCs are generated from adult somatic cells by reprogramming them into an embryonic-like state via the expression of transcription factors required for establishing pluripotency.
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