Publications by authors named "Senanayake S"

The disadvantaged populations eGFR (estimated glomerular filtration rate) epidemiology (DEGREE) study was designed to gain insight into the burden of chronic kidney disease (CKD) of undetermined cause (CKDu) using standard protocols to estimate the general-population prevalence of low eGFR internationally. Therefore, we estimated the age-standardized prevalence of eGFR under 60 ml/min per 1.73m in adults aged 18-60, excluding participants with commonly known causes of CKD; an ACR (albumin/creatinine ratio) over 300 mg/g or equivalent, or self-reported or measured (HT) hypertension or (DM) diabetes mellitus, stratified by sex and location.

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Introduction: Kidney failure can be managed either conservatively or via kidney replacement therapy. Kidney supportive care combines the expertise of nephrology with palliative care in a multidisciplinary team with a focus on improving quality of life.

Objective: To identify and appraise evidence-based health system kidney supportive care interventions DESIGN: Systematic review (PROSPERO Registration - CRD42022333650).

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Article Synopsis
  • The DEGREE study explored the impact of chronic kidney disease of undetermined cause (CKDu) globally by analyzing the prevalence of low estimated glomerular filtration rate (eGFR) in adults aged 18-60, focusing on participants without known CKD causes.
  • The study included data from 60,964 participants across 43 areas in 14 countries collected from 2007 to 2023, revealing the highest CKDu prevalence in rural areas of Uddanam, India, and Northwest Nicaragua (14%).
  • The findings indicate that CKDu is notably prevalent in specific regions, especially within Central America and South Asia, prompting the need for global monitoring while acknowledging the potential existence of unidentified disease clusters elsewhere.
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Background: Leishmaniasis has emerged as an escalating public health problem in Sri Lanka, with reported cases increasing nearly three folds over past decade, from 1,367 in 2014 to 3714 cases in 2023. Phlebotominae sand flies are the vectors of leishmaniasis. Their density is known to be influenced by context-specific climatic and land use patterns.

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This study investigated the applicability of the biodegradable films and coatings prepared from gelatin extracted from jellyfish using two extraction methods; conventional hot water extraction and microwave-assisted extraction, for the preservation of strawberries under refrigerated storage (4 °C), compared to biodegradable films and coatings prepared from analytical grade cold water fish skin gelatin and porcine skin gelatin. After 21 days of storage, uncoated strawberries (control group) exhibited visual decay and fungal attacks while coated or film-wrapped strawberries exhibited a better appearance. Coating or wrapping with gelatin films significantly reduced the weight loss of strawberries and the changes in color, hardness, moisture content, pH, titratable acidity, and total soluble solids of coated/film-wrapped fruits during storage were minimal compared to the uncoated fruits.

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  • The study compares the effectiveness of two quality-of-life measurement tools for children: ECOHIS-4D, focused on oral health, and EQ-5D-Y, a general tool.
  • Researchers evaluated these tools based on their validity, ability to distinguish varying clinical severities, responsiveness to health changes, and correlation with dental health scores (dfs) among children.
  • Findings indicate that ECOHIS-4D is significantly more effective in measuring oral health-related quality of life in children compared to EQ-5D-Y, as it showed better correlations with actual dental health outcomes.
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  • Home-based palliative and supportive care for heart failure patients enhances quality of life and reduces healthcare costs while benefiting caregivers.
  • This study aims to identify and describe the essential components of such care, using a scoping review methodology.
  • Key findings indicate that a multidisciplinary team, led by nurses, is crucial for effective symptom management, education, and advance care planning in this context, which points to a need for future research on digital interventions and team composition.
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Phlebotomus argentipes is the established vector of leishmaniasis in the Indian sub-continent. Antibodies to sand fly salivary antigens are biomarkers for vector-host exposure in leishmaniasis-endemic regions. Ph.

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The impact of non-motor symptoms is often overlooked in favour of the motor symptoms when managing Parkinson's disease resulting in suboptimal patient outcomes. This study aimed to characterise the non-motor symptoms of Parkinson's disease in a cohort of Sri Lankan patients with a special focus on the impulsive control disorders and other compulsive behaviours (ICDs-CB) that had not been previously studied in this population. All patients with idiopathic Parkinson's disease followed up at the National Hospital of Colombo, Sri Lanka were included.

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Objectives: Microwave ablation (MWA) has gained attention as a minimally invasive and safe alternative to surgical intervention for patients with small renal masses; however, its cost-effectiveness in Australia remains unclear. This study conducted a cost-effectiveness analysis to evaluate the relative clinical and economic merits of MWA compared to robotic-assisted partial nephrectomy (RA-PN) in the treatment of small renal masses.

Methods: A Markov state-transition model was constructed to simulate the progression of Australian patients with small renal masses treated with MWA versus RA-PN over a 10-year horizon.

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  • This study focused on understanding the yearly healthcare costs associated with heart failure (HF) patients in Singapore, specifically those with reduced ejection fraction (<40%).
  • It analyzed data from 2011 through 2019, showing a decline in hospital admissions overall while noting stable per-patient admission costs, which ranged from S$16,000 to S$18,800 annually.
  • The findings indicate that healthcare costs significantly increase in the final year of life, highlighting the need for more cost-effective management approaches to alleviate financial strain on Singapore's healthcare system.
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Introduction: Identifying and addressing neurodevelopmental delays in children can be challenging for families and the healthcare system. Delays in accessing services and early interventions are common. The design and delivery of these services, and associated outcomes for children, may be improved if service provision aligns with families' needs and preferences for receiving care.

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  • Researchers developed monometallic Pd-CeO catalysts, enhanced with carbon, that achieve 100% selectivity for converting methane to methanol at 75 °C, using hydrogen peroxide as an oxidizer.
  • The catalysts were created through a simple mechanochemical method that produces a unique interface (Pd-iC-CeO), which optimizes the interaction between metal and oxide components for better performance.
  • A DFT-simulated Eley-Rideal-like mechanism showed that solvent interactions, specifically with water (HO (aq)), are crucial for maintaining methanol selectivity in the solid-liquid-gas conversion process.
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is the established vector of leishmaniasis in the Indian sub-continent. Antibodies to sand fly salivary antigens are biomarkers for vector-host exposure in leishmaniasis-endemic regions. transmits in Sri Lanka, primarily causing cutaneous leishmaniasis (CL).

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Purpose: To identify the key attributes of breast cancer follow-up care models preferred by cancer survivors in Australia.

Methods: A discrete choice experiment (DCE) was conducted to elicit preferences for attributes of breast cancer follow-up care. Respondents were presented with two hypothetical scenarios, known as choice sets, and asked to select a preference.

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Background: The growth in online qualitative research and data collection provides several advantages for health service researchers and participants, including convenience and extended geographic reach. However, these online processes can also present unexpected challenges, including instances of participant fraud or scam behaviour. This study describes an incident of participant fraud identified during online focus group discussions and interviews for a PhD health services research project on paediatric neurodevelopmental care.

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Introduction: The Kansas City Cardiomyopathy Questionnaire (KCCQ), Seattle Angina Questionnaire (SAQ), and Minnesota Living with Heart Failure Questionnaire (MLHFQ) are widely used non-preference-based instruments that measure health-related quality of life (QOL) in people with heart disease. However, currently it is not possible to estimate quality-adjusted life-years (QALYs) for economic evaluation using these instruments as the summary scores produced are not preference-based. The MacNew-7D is a heart disease-specific preference-based instrument.

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Palladium catalysts are frequently employed in processes where methanol is an energy vector or carrier, being useful for the synthesis of methanol from mixtures of carbon dioxide and hydrogen (CO/H) or its steam reforming on demand. Results of synchrotron-based ambient pressure X-ray photoelectron spectroscopy for the adsorption of methanol on a Pd(111) model catalyst show a rich surface chemistry and complex phenomena that strongly depend on pressure and temperature. At low pressures (<10 Torr) and temperatures (<300 K), CO is the dominant decomposition product.

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  • Electrification is crucial for reducing greenhouse gas emissions and combating climate change, but many sectors like aviation, heavy-duty transport, and chemicals will still rely on carbon.
  • The Roadmap highlights multidisciplinary strategies to create a circular economy by finding alternatives to carbon and enhancing carbon reuse through advanced separation technologies.
  • Emphasizing collaboration and applied scientific research is key to achieving significant reductions in greenhouse gas emissions.
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  • Trauma-informed care practices promote safety for individuals after traumatic events, especially in medical contexts, like pediatric burn treatments.
  • The 'Responsive CARE' training program was created to enhance the knowledge of healthcare professionals on trauma-informed practices, and its implementation was evaluated using various methods.
  • A small group of health professionals participated in the training, revealing themes that affected its feasibility and acceptability, while initial data suggested the training could impact child pain and distress in burn treatment scenarios.
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Background: It is essential to consider the evidence of consumer preferences and their specific needs when determining which strategies to use to improve patient attendance at scheduled healthcare appointments.

Objectives: This study aimed to identify key attributes and elicit healthcare consumer preferences for a healthcare appointment reminder system.

Methods: A discrete choice experiment was conducted in a general Australian population sample.

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Objectives: This scoping review mapped and synthesised original research that identified low-value care in hospital settings as part of multicomponent processes.

Design: Scoping review.

Data Sources: Electronic databases (EMBASE, PubMed, CINAHL, PsycINFO and Cochrane CENTRAL) and grey literature were last searched 11 July and 3 June 2022, respectively, with no language or date restrictions.

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Leishmaniasis is considered one of the neglected tropical diseases in the world. Although Bhutan is a member of the visceral leishmaniasis elimination consortium in South Asia, not much attention has been accorded to the disease because of its low incidence. The vector that transmits Leishmania remains poorly understood.

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