Publications by authors named "Sena Atici"
Molecular mechanisms of PI3K isoform dependence in embryonic growth.
J Turk Ger Gynecol Assoc
August 2024
Objective: The phosphoinositide 3-kinase (PI3K) pathway is an important signaling mechanism for cell proliferation and metabolism. Mutations that activate PIK3CA may make cells p110α dependent, but when phosphatase tensin homolog (PTEN) is lost, the p110β isoform of PI3Ks becomes more important. However, the exact mechanism underlying the prevalence of p110s remains unclear.
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- - Ferroptosis is a unique cell death process that could help treat certain cancers by targeting the way tumors manage lipid oxidation.
- - A study has found that 7-dehydrocholesterol (7-DHC), which was thought to be harmful to neurons, actually helps cancer cells survive by protecting their membranes from oxidative damage.
- - In experiments with neuroblastoma and Burkitt's lymphoma, high levels of 7-DHC were linked to a shift in tumors that makes them more aggressive and resistant to ferroptosis, suggesting a potential cancer survival strategy.
Article Synopsis
- PTEN and PIK3CA mutations are common in several cancers and loss of PTEN leads to increased activity of the p110β isoform of the PI3K pathway.
- The study found that the enzyme SQLE, important for cholesterol production, is upregulated in PTEN-deficient prostate tumors, and its levels are connected with PI3K activation.
- Targeting cholesterol biosynthesis alongside hormone receptor signaling may enhance treatment effectiveness for hormone-resistant prostate and breast cancers that lack PTEN.