[Chemical constituents from fruits of Aristolochia mollissima and their nematicidal activity against root-knot nematode].

In the present study, in vitro nematicidal activity of chemical compositions from the methanol extract of Aristolochia mollissima fruits against the second stage juvenile (J2) of Meloidogyne javanica have been investigated. By using silica gel column chromatography, Sephadex LH-20 gel column chromatography methods, fourteen compounds were isolated from methanol extract of A. mollissima fruits.

Aristololactam derivatives from the fruits of Aristolochia contorta Bunge.

Three new aristololactam derivatives, aristololactam W-Y (1-3), and three known compounds (4-6) were isolated from the fruits of Aristolochia contorta Bunge. Compounds 1 and 2 represent the first example of an N-CHOCH aristololactam derivative from natural products. Their structures were elucidated by 1D/2D NMR and HRESIMS spectra.

[A multi-center randomized controlled trial of intrauterine device use in Chinese women].

Objective: To assess the safety and effectiveness of intrauterine device in Chinese women.

Methods: In this multicenter randomized controlled trial, a total of 24 000 women were randomly (1:1:1) into 3 groups of Yuangong Cu 365 (YCu365), Copper T 380A (TCu380A) and Multiload Cu 375 (MLCu375). Clinical outcomes were assessed at 12 months post-insertion, including discontinuation due to pregnancy, expulsion, hemorrhage and downward displacement, etc.