Publications by authors named "Sen Yachi"
Article Synopsis
- The CLOT-COVID Study analyzed 2894 hospitalized patients with COVID-19, focusing on 1738 patients with mild cases who didn’t need oxygen at admission.
- Patients were split into two groups: those receiving prophylactic anticoagulation (326 patients) and those who were not (1412 patients).
- Results showed that those on anticoagulation had higher severity levels during hospitalization and a slightly higher incidence of thrombosis, suggesting that routine use may not be beneficial for all stable patients.
This study aimed to investigate the clinical features of arterial thrombosis and venous thromboembolism (VTE) in coronavirus disease 2019 (COVID-19). The CLOT-COVID Study was a retrospective, multicenter cohort study that enrolled 2,894 consecutively hospitalized patients with COVID-19 among 16 centers in Japan from April 2021 to September 2021. We compared the clinical features of arterial thrombosis and VTE.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the association between thrombosis and clinical outcomes in hospitalized COVID-19 patients in Japan, using data from the CLOT-COVID study.
- Patients with thrombosis (55 individuals) experienced significantly higher mortality (23.6% vs. 5.1%) and major bleeding events (23.6% vs. 1.6%) compared to those without thrombosis (2839 individuals).
- Independent risk factors for thrombosis included being male, having elevated D-dimer levels on admission, and severe COVID-19 status, which could help guide treatment decisions for these patients.
Article Synopsis
- The study focused on understanding the use of prophylactic anticoagulation for COVID-19 patients in Japan, highlighting its clinical management strategies.
- Conducted as a multicenter observational study, it involved 2,894 hospitalized patients, ultimately analyzing 2,889 patients based on their anticoagulation treatment.
- Results revealed that the severity of COVID-19 at admission strongly influenced the use of pharmacological thromboprophylaxis and therapeutic dosing, particularly in patients with comorbidities.
Background: Reports of mortality-associated risk factors in patients with the novel coronavirus disease 2019 (COVID-19) are limited.
Methods: We evaluated the clinical features that were associated with mortality among patients who died during hospitalization (n = 158) and those who were alive at discharge (n = 2,736) from the large-scale, multicenter, retrospective, observational cohort CLOT-COVID study, which enrolled consecutively hospitalized COVID-19 patients from 16 centers in Japan from April to September 2021. Data from 2,894 hospitalized COVID-19 participants of the CLOT-COVID study were analyzed in this study.
Background: The coronavirus disease 2019 (COVID-19) causes extensive coagulopathy and a potential benefit of anticoagulation therapy has been documented for prevention of thromboembolic events. Bleeding events has also been reported as a notable complication; whereas, the incidence, risks, and clinical impact of bleeding remain unclear.
Method: The CLOT-COVID Study was a nationwide, retrospective, multicenter cohort study on consecutive hospitalized patients with COVID-19 in Japan between April 2021 and September 2021.
Article Synopsis
- Obesity's impact on COVID-19 severity and thrombosis risk was explored in the CLOT-COVID study, involving 2,690 hospitalized patients in Japan from April to September 2021.
- The study found that patients with obesity had more severe COVID-19 symptoms at admission and a higher risk for serious outcomes (like mechanical ventilation) but no significant difference in thrombosis rates compared to non-obese patients.
- Overall, while obesity did not significantly increase the risk of thrombosis, it was linked to worsened COVID-19 severity and worse hospitalization outcomes.
Aim: There is scarce data on the impact of age on clinical outcomes in patients with coronavirus disease 2019 (COVID-19).
Method: The CLOT-COVID Study was a retrospective, multicenter cohort study enrolling 2894 consecutive hospitalized patients with COVID-19 among 16 centers in Japan from April 2021 to September 2021. We divided the entire cohort into five groups according to age strata; -19, 20-39, 40-59, 60-79, and 80- years.
Background: The worsening of coronavirus disease 2019 (COVID-19) severity is a critical issue in current clinical settings and may be associated with the development of thrombosis.
Methods and results: This study used patient data obtained in the CLOT-COVID study, a retrospective multicenter cohort study. The demographics of patients with moderate COVID-19 on admission with and without worsened severity during hospitalization were compared and predictors were identified.
Article Synopsis
- The CLOT-COVID study examined the effectiveness of therapeutic-dose versus prophylactic-dose anticoagulation in critically ill patients with severe COVID-19.
- The study involved 225 patients requiring advanced respiratory support, finding no significant difference in thrombosis rates between the two groups (9.1% for therapeutic vs. 7.8% for prophylactic, P=0.73).
- Ultimately, the results indicated that therapeutic-dose anticoagulation did not provide additional benefits compared to prophylactic dosing for these patients.
To date, there are no large-scale data on the association between D-dimer levels at admission and the occurrence of venous thromboembolism (VTE) in Japanese patients with coronavirus disease 2019 (COVID-19). The CLOT-COVID study was a retrospective, multicenter cohort study enrolling consecutive hospitalized patients with COVID-19 across 16 centers in Japan from April 2021 to September 2021. Among 2,894 enrolled patients, 2,771 (96%) had D-dimer levels measured at admission.
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- Data on thrombosis and anticoagulation management in COVID-19 patients is limited, making the CLOT-COVID Study important for understanding treatment challenges.
- The study analyzed 2,894 hospitalized patients in Japan, finding that 43% received thromboprophylaxis, with usage increasing by COVID-19 severity (from 9.8% in mild cases to 97% in severe cases).
- The study revealed low thrombosis rates (1.9%) but higher incidences in severe cases, with major bleeding occurring in 2% of patients and 5.5% dying primarily from respiratory failure.
Article Synopsis
- The CLOT-COVID Study analyzed 2894 hospitalized COVID-19 patients in Japan, focusing on how sex affects thrombosis development.
- Results showed men experienced more severe COVID-19 symptoms at admission and were more likely to receive thrombosis prevention treatment compared to women.
- Men also had a significantly higher incidence of thrombosis during hospitalization, indicating a need for sex-specific management strategies for COVID-19 patients.
Background: Coronavirus disease 2019 (COVID-19) reportedly causes venous thromboembolism (VTE), but the status of this complication in Japan was unclear.
Methods and results: The VTE and COVID-19 in Japan Study is a retrospective, multicenter cohort study enrolling hospitalized patients with COVID-19 who were evaluated with contrast-enhanced computed tomography (CT) examination at 22 centers in Japan between March 2020 and October 2020. Among 1,236 patients with COVID-19, 45 (3.
The aim of this study was to address 7-year clinical outcomes and impact of prolonged dual antiplatelet therapy (DAPT) after coronary stenting in hemodialysis patients. Our study included 123 consecutive hemodialysis patients who had undergone percutaneous coronary intervention with a drug-eluting stent (DES) or bare-metal stent (BMS) (DES: 64, BMS: 59) in our institution. We compared long-term clinical outcomes following DES with BMS implantation as well as clinical outcomes in patients on DAPT for ≥1 year (DAPT on group, 89) with those on DAPT for <1 year (DAPT off group, 34).
View Article and Find Full Text PDFA 46-year-old man with a history of hypertension, chronic kidney disease, and chronic aortic dissection classified as DeBakey type IIIB was referred to our hospital with chest and back pain. The patient underwent 64-row multidetector computed tomography (MDCT), which revealed new-onset DeBakey type II aortic dissection. The intimal flap prolapsed into left ventricle in the diastolic phase of cardiac cycle and stuck to the right coronary cusp (RCC) of the aortic valve.
View Article and Find Full Text PDFThere remain a small but sizable number of patients who develop restenosis after sirolimus-eluting stent (SES) implantation. However, the cause of SES restenosis has not been fully elucidated. The study population consisted of 52 patients with 69 lesions who underwent noninvasive coronary imaging by 64-slice multidetector computed tomography before SES deployment.
View Article and Find Full Text PDFAims: This study was performed to assess the differences in culprit plaque composition between patients with and without pre-infarction angina (PA) by using spectral analysis of intravascular ultrasound (IVUS) radiofrequency (RF) data.
Methods And Results: Of 57 patients consecutively admitted to our institution with acute myocardial infarction, pre-intervention IVUS RF data of culprit plaques were obtained and analysed in 35 patients after percutaneous aspiration thrombectomy. Among the 35 patients, 21 patients had PA.
The long-term success rate of the Cox maze III procedure is excellent, although it has not been widely adopted because of the need for extensive incisions of the atria. In this study, we report our experience with a closed biatrial procedure using bipolar radiofrequency (RF) ablation for treating atrial fibrillation (AF) during non-mitral cardiac operations. Beginning in December 2004, a total of 19 patients underwent a closed biatrial procedure with bipolar RF energy.
View Article and Find Full Text PDFBackground: Percutaneous coronary intervention for hemodialysis patients has been hampered by the high rate of adverse cardiac events. Our aim was to investigate whether sirolimus-eluting stents (SESs) improve clinical outcomes of hemodialysis patients compared with bare-metal stents (BMSs).
Study Design: Retrospective study.
Article Synopsis
- The study evaluates the composition of culprit plaques in acute coronary syndrome (ACS) patients, focusing on differences between those experiencing the no-reflow phenomenon and those who do not.
- Intravascular ultrasound data was analyzed from 49 ACS patients, revealing that plaques associated with the no-reflow phenomenon had a higher necrotic core percentage and lower fibrous component than those without it.
- The percentage of necrotic core was identified as a key independent predictor of the no-reflow phenomenon, highlighting significant differences in plaque characteristics between the two groups.
Background: It has been reported that multidetector spiral computed tomography (MDCT) allows the classification of coronary plaques by measuring computed tomography (CT) density values. However, the impact of CT density values in culprit lesions on the occurrence of transient no-reflow during percutaneous coronary intervention (PCI) has not been investigated.
Methods: The study population consisted of 51 consecutive patients who were diagnosed as having coronary artery disease by 64-slice MDCT before PCI.
Background: Metallic allergy is associated with restenosis following bare metal stent implantation, but the impact of metallic allergy on the outcome after implantation of drug-eluting stents (DES) has not been investigated.
Methods And Results: The present study group consisted of 88 consecutive patients (109 lesions) who underwent percutaneous coronary intervention with sirolimus-eluting stents (SES). Follow-up angiography was obtained at 8 months in all patients.
Background: The relationship between coronary artery remodeling and culprit plaque composition in vivo has not been fully evaluated by spectral analysis of intravascular ultrasound (IVUS) radiofrequency (RF) data.
Methods And Results: IVUS RF analyses were performed for 56 consecutive de novo culprit lesions of 52 patients undergoing percutaneous coronary intervention. Remodeling of culprit lesions was determined using the remodeling index (RI), calculated as the external elastic membrane area of the minimum lumen area (MLA) site divided by that of the proximal reference site.
Incidence and clinical impact of coronary stent fracture after sirolimus-eluting stent implantation.
Catheter Cardiovasc Interv
February 2007
Background: Stent fracture is one of the possible causes of restenosis after sirolimus-eluting stents (SES) implantation. The aim of our study was to evaluate the prevalence and clinical impact of coronary stent fracture after SES implantation.
Methods: From our prospective institutional database, 280 patients were treated solely with SES from August 2004 to June 2005.