DNA Ploidy Analysis and Cell Block Immunohistochemistry in the Diagnosis of Malignant Effusions.

Background: Effusion cytology is a major diagnostic tool in medicine and has both therapeutic and prognostic implications. One of the dilemmas encountered is the differentiation between atypical cells and reactive mesothelial cells. The use of ancillary tools can reduce this grey zone and help to achieve a definitive diagnosis.

Autoimmune pancreatitis masquerading as carcinoma head of pancreas: A case report and review of literature.

Introduction: Autoimmune pancreatitis (AIP) is a rare form of chronic inflammatory pancreatic disease secondary to an underlying autoimmune mechanism. It is now considered as pancreatic manifestation of IgG4 related disease, which is a multisystem disease.

Case Report: We are reporting a patient who presented with obstructive jaundice and mass head of pancreas on Computed Tomography (CT) scan.

Cluster Quality based Non-Reductional (CQNR) oversampling technique and effector protein predictor based on 3D structure (EPP3D) of proteins.

Background: Effector proteins of bacteria infect their hosts by specific dedicated machinery identified as secretion systems. Currently, no mechanism to identify the effector proteins based on their 3D structure has been reported in the literature. In order to identify effector proteins, extraction of features from their 3D structure is crucial.

Modified Stoppa Approach for Acetabulum Fracture: A Review.

Fracture acetabulum is a grave injury and a challenge for orthopedic surgeons. Anterior and posterior approaches have been described for fixation of acetabulum fractures. The modified Stoppa approach is considered an alternate to anterior approach, which provides access to pelvis from inside the cavity.

Predictors of preoperative endovascular embolization of meningiomas: subanalysis of anatomic location and arterial supply.

Introduction: Endovascular embolization of intracranial meningiomas is commonly used as an adjunct to surgical resection. We sought to describe the anatomic locations and vascular supplies of meningiomas to identify characteristics predictive of successful preoperative endovascular embolization.

Methods: We conducted a retrospective review of 139 meningioma cases receiving cerebral angiograms for possible preoperative endovascular embolization at our institution between December 2000 and March 2017.

'Primary small cell carcinoma of tonsil: An extreme rarity.'.

Introduction: Small cell neuroendocrine carcinoma (NEC) that originates in the tonsil is extremely rare and carries a poor prognosis. Only a few cases of this tumor have been reported so far and the standard treatment protocol remains uncertain.

Case Report: Here, we describe a 65-year-old woman presenting with throat pain.

Moving toward a systematic approach for reporting salivary gland cytopathology: cytohistological correlation with the application of the Milan system for risk stratification at a tertiary care center.

Introduction: Fine-needle aspiration cytology (FNAC) of salivary glands is a well-established technique that plays a critical role in the preoperative diagnosis of lesions. Despite its clinical utility, it remains one of the most challenging areas in cytopathology. This is because there is no consensus on how to report salivary gland cytopathology, which has resulted in inconsistent terminology and confusion in communication among cytopathologists and clinicians.

PyPredT6: A python-based prediction tool for identification of Type VI effector proteins.

Prediction of effector proteins is of paramount importance due to their crucial role as first-line invaders while establishing a pathogen-host interaction, often leading to infection of the host. Prediction of T6 effector proteins is a new challenge since the discovery of T6 Secretion System and the unique nature of the particular secretion system. In this paper, we have first designed a Python-based standalone tool, called PyPredT6, to predict T6 effector proteins.

Clinical outcomes and cost-effectiveness analysis for the treatment of basilar tip aneurysms.

Background: Endovascular treatment of basilar tip aneurysms is less invasive than microsurgical clipping, but requires closer follow-up.

Objective: To characterize the additional costs associated with endovascular treatment of basilar tip aneurysms rather than microsurgical clipping.

Materials And Methods: We obtained clinical records and billing information for 141 basilar tip aneurysms treated with clip ligation (n=48) or endovascular embolization (n=93).

A biorefinery for valorization of industrial waste-water and flue gas by microalgae for waste mitigation, carbon-dioxide sequestration and algal biomass production.

Massive industrialization all over the globe is the main cause for the generation of huge quantity of wastes such as flue gas and wastewaters. Mindless release of these hazardous wastes into the environment is threatening the health and survival of the mankind. Judicious use of these wastes for microalgal biomass cultivation is recognized as a plausible approach for the creation of a renewable and sustainable process chain for biofuel production.

Electrodeposited functionally graded coating inhibits Gram-positive and Gram-negative bacteria by a lipid peroxidation mediated membrane damage mechanism.

The current work deals with a time-dependent study to track the antibacterial action of electrodeposited Cu, Cu-SiC functionally graded coating (FGC) against Escherichia coli NCIM 2931 (Gram-negative) and Bacillus subtilis NCIM 2063 (Gram-positive). After 24 h of incubation, the Cu, Cu-SiC FGC causes 7 Escherichia coli NCIM 2931 and 10 Bacillus subtilis NCIM 2063 log reduction of planktonic cells. The outer membrane permeabilization experiment proves that the intake of excessive Cu ions leads to the damage of bacterial cell membrane followed by lipid degradation.

Immune Differentiation Regulator p100 Tunes NF-κB Responses to TNF.

Tumor necrosis factor (TNF) is a pleiotropic cytokine whose primary physiological function involves coordinating inflammatory and adaptive immune responses. However, uncontrolled TNF signaling causes aberrant inflammation and has been implicated in several human ailments. Therefore, an understanding of the molecular mechanisms underlying dynamical and gene controls of TNF signaling bear significance for human health.

Strategic valorization of de-oiled microalgal biomass waste as biofertilizer for sustainable and improved agriculture of rice (Oryza sativa L.) crop.

Intensive use of chemical fertilizer results in environmental pollution that disturbs the local ecosystem and causes reduction in the long-term crop yield. There is a need to explore the alternative source of plant nutrition such as de-oiled microalgal biomass as biofertilizer for sustainable production of food crops in a relatively pollution free environment. This study reports sustainable and improved agriculture of rice crop (cv.

Safety, Efficacy, and Patient-Reported Health-Related Quality of Life and Symptom Burden with Nivolumab in Patients with Advanced Non-Small Cell Lung Cancer, Including Patients Aged 70 Years or Older or with Poor Performance Status (CheckMate 153).

Introduction: CheckMate 153 (NCT02066636) is a phase 3B/4 study assessing nivolumab in previously treated patients with advanced NSCLC. Eligibility criteria allowed enrollment of patients with poor prognostic features of advanced age or diminished Eastern Cooperative Oncology Group performance status (ECOG PS), which are typically underrepresented in or excluded from randomized controlled trials.

Methods: Patients with stage IIIB or IV NSCLC and an ECOG PS of 0 to 2 with disease progression after at least one systemic therapy received nivolumab (3 mg/kg every 2 weeks) until progression, unacceptable toxicity, or consent withdrawal.

A mycobacteriophage genomics approach to identify novel mycobacteriophage proteins with mycobactericidal properties.

Mycobacteriophages that are specific to mycobacteria are sources of various effector proteins that are capable of eliciting bactericidal responses. We describe a genomics approach in combination with bioinformatics to identify mycobacteriophage proteins that are toxic to mycobacteria upon expression. A genomic library comprising phage genome collections was screened for clones capable of killing Mycobacterium smegmatis strain mc155.

Comparison of full-endoscopic and minimally invasive decompression for lumbar spinal stenosis in the setting of degenerative scoliosis and spondylolisthesis.

OBJECTIVEThe management of lumbar spinal stenosis (LSS) with concurrent scoliosis and/or spondylolisthesis remains controversial. Full-endoscopic unilateral laminotomy for bilateral decompression (ULBD) facilitates neural decompression while preserving stabilizing osseoligamentous structures and may be uniquely suited for the treatment of LSS with concurrent mild to moderate degenerative deformity. The safety and efficacy of full-endoscopic versus minimally invasive surgery (MIS) ULBD in this patient population is studied here for the first time.

Rogue waves in a linear cavity Yb-fiber laser through spectral filtering induced pulse instability.

In this Letter, experimental observation of dissipative rogue waves (DRWs) due to spectral filtering induced pulse instabilities in a mode-locked ytterbium (Yb) fiber laser has been presented. A semiconductor saturable absorber mirror was used to mode-lock the linear cavity laser and a chirped fiber Bragg grating (CFBG) was used for dispersion management, which also acted as a spectral filter and output coupler. Under stable conditions, the cavity delivered dispersion managed dissipative solitons of 447 fs duration and 0.

Inclusion of Ln(III) in the Complexes of Co(II) with a Mannich Base Ligand: Development of Atmospheric CO Fixation and Enhancement of Catalytic Oxidase Activities.

The reaction of the Mannich base ligand (HL = N, N'-dimethyl- N, N'-bis(2-hydroxy-3-methoxy-5-methylbenzyl)ethylenediamine) with Co(OAc)·4HO and Ln(III) nitrate salts (Ln = Gd, Tb, and Dy) under basic conditions afforded three carbonato-bridged isostructural tetranuclear heterometallic Co(II)-Ln(III) complexes (CoGdL(μ-CO)(NO)] (1), [CoTbL(μ-CO)(NO)] (2), and [CoDyL(μ-CO)(NO)] (3)) by atmospheric CO fixation. In all structures, two dinuclear [(CoL)Ln(NO)] units are linked via two μ-carbonato groups to form the tetranuclear CoLn core. The geometry around two penta-coordinated Co(II) ions is distorted square pyramid, and that around two nona-coordinated Ln(III) ions is intermediate between "spherical tricapped trigonal prism" and "spherical capped square antiprism" in all complexes.

Isolated myeloid sarcoma of the temporal bone: As the first clinical manifestation of acute myeloid leukemia in a patient of down's syndrome.

Introduction: Leukemia is the most common malignancy of childhood but myeloid sarcoma is a rare presentation of underlying leukemic disorder. Myeloid sarcoma (MS) is a rare tumor composed of proliferation of myeloid precursors at extramedullary sites.

Presentation Of Case: We report an unusual case of myeloid sarcoma involving the temporal bone in a young male child who presented with a large mass involving the left temporal region.

Comparative Analysis of Liquid based and Conventional Cytology Smears in Fine Needle Aspirates from Breast Lesions.

Context: Liquid-based cytology (LBC) is being extensively used for the evaluation of both gynecological and non-gynecological specimens. Suspension of cells in monolayer makes better morphological assessment possible. Along with this, inherent morphological changes such as altered, reduced, or lost background material, fragmented cell clusters, smaller cell size, nucleolar prominence, etc.

Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging.

Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding of the biological changes that are induced by physical activity in skeletal muscle is required. To determine the effect of physical activity on the skeletal muscle proteome, we utilized liquid-chromatography mass spectrometry to obtain quantitative proteomics data on human skeletal muscle biopsies from 60 well-characterized healthy individuals (20-87 years) who reported heterogeneous levels of physical activity (not active, active, moderately active, and highly active).

Noncoding variations in Cyp24a1 gene are associated with Klotho-mediated aging phenotypes in different strains of mice.

In mutant mice, reduced levels of Klotho promoted high levels of active vitamin D in the serum. Genetic or dietary manipulations that diminished active vitamin D alleviated aging-related phenotypes caused by Klotho down-regulation. The hypomorphic Klotho [kl/kl] allele that decreases Klotho expression in C3H, BALB/c, 129, and C57BL/6 genetic backgrounds substantially increases 1,25(OH)2D3 levels in the sera of susceptible C3H, BALB/c, and 129, but not C57BL/6 mice.

Performance evaluation of an outdoor algal biorefinery for sustainable production of biomass, lipid and lutein valorizing flue-gas carbon dioxide and wastewater cocktail.

We evaluated wastewater remediation and CO utilization potential of Chlorella minutissima from flue gas in a raceway pond, while synthesizing lutein and lipid for potential healthcare and biofuel application. A mix of 20% kitchen waste, 10 g L of poultry litter waste and 5% flue gas was maintained while cultivating the microalga. Complete removal of nitrate, nitrite and ammonium, 85% carbon and 91% phosphorus was observed.

Rho-dependent transcription termination in bacteria recycles RNA polymerases stalled at DNA lesions.

In bacteria, transcription-coupled repair of DNA lesions initiates after the Mfd protein removes RNA polymerases (RNAPs) stalled at the lesions. The bacterial RNA helicase, Rho, is a transcription termination protein that dislodges the elongation complexes. Here, we show that Rho dislodges the stalled RNAPs at DNA lesions.