Influence of gingival color and abutment material on the final color of peri-implant soft tissue: An in vitro analysis.

The study aimed to investigate the influence of different gingival colors and abutment materials on the final color of peri-implant soft tissue. A total of 30-cylinder shaped specimens having 1.0- and 2.

Effect of graphene oxide on the biaxial flexural strength and translucency of ultrathin monolithic zirconia.

Purpose: The purpose of this study was to investigate the influence of graphene oxide (GO) and hydrothermal aging on the biaxial flexural strength (BFS) and translucency (TP) of ultrathin monolithic zirconia with different yttria concentrations.

Methods: Disc shaped specimens (n = 120) were milled using zirconia blocks (YZ-HT [HT], YZ-ST [ST], and YZ-XT [XT]) with a diameter of 15.0 mm and a thickness of 0.

Lipid-polymer hybrid-vesicles interrupt nucleation of amyloid fibrillation.

Solubility and aggregation of proteins are crucial factors for their functional and further biological roles. Aggregation of proteins , such as the amyloid beta (Aβ) peptide into fibrils, is significantly modulated by membrane lipids, abundantly present in cells. We developed a model membrane system, composed of lipid hybrid-vesicles bearing embedded hydrophilic polymers to study the aggregation of the Aβ peptide.

Regional variations in psoriatic arthritis: Insights from a nationwide multicenter analysis in Türkiye.

Objectives: The study aimed to investigate and compare clinical features, disease activity, and the overall disease burden among psoriatic arthritis (PsA) patients across seven distinct geographic regions in Türkiye.

Patients And Methods: A multicenter cross-sectional study involving 1,134 PsA patients from 25 referral centers across seven regions was conducted. Demographic and clinical characteristics, comorbidities, joint involvement, extra-articular manifestations, and disease activity measures were evaluated across regions.

Validity and reliability of the Sustainable HEalthy Diet (SHED) index by comparison with EAT-Lancet diet, Mediterranean diet in Turkish adults.

Background: Food consumption and diet are strongly associated with sustainability. The Sustainable HEalthy Diet index was developed to measure the nutritional, environmental, and sociocultural components of sustainable diets and healthy eating patterns. However, a methodological approach has yet to be proposed for Turkish adults.

Investigation of groundwater quality in the Southern Coast of the Black Sea: application of computational health risk assessment in Giresun, Türkiye.

Potentially toxic elements (PTEs), especially arsenic in drinking water, pose significant global health risks, including cancer. This study evaluates the groundwater quality in Giresun province on the Black Sea coast of Türkiye by analyzing twelve groundwater resources. The mean concentrations of macronutrients (mg/L) were: Ca (10.

Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain.

Biological membranes are partitioned into functional zones termed membrane microdomains, which contain specific lipids and proteins. The composition and organization of membrane microdomains remain controversial because few techniques are available that allow the visualization of lipids in situ without disrupting their native behaviour. The yeast eisosome, composed of the BAR-domain proteins Pil1 and Lsp1 (hereafter, Pil1/Lsp1), scaffolds a membrane compartment that senses and responds to mechanical stress by flattening and releasing sequestered factors.

Masking ability of gingiva-colored resin-based composites over different tooth-colored substrates.

The purpose of the study was to investigate the influence of different tooth-colored substrates and restoration thicknesses on the final color of gingiva-colored resin-based composites (GCRBCs). Five different shades of GCRBCs [light pink (LP), dark pink (DP), orange (Or), brown (Br), and purple (P)] were used to prepare disc-shaped specimens with 2 different thicknesses: 1.0 mm, and 2.

Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition.

Background: Inhibition of kinases is the ever-expanding therapeutic approach to various types of cancer. Typically, assessment of the treatment response is accomplished by standard, volumetric imaging procedures, performed weeks to months after the onset of treatment, given the predominantly cytostatic nature of the kinase inhibitors, at least when used as single agents. Therefore, there is a great clinical need to develop new monitoring approaches to detect the response to kinase inhibition much more promptly.

Influence of gingival color on the color differences of dental laminate veneers.

Statement Of Problem: The effect of various gingival colors on the color differences of laminate veneers is unclear and comparative evaluations should be documented.

Purpose: The purpose of this in vitro study was to investigate the influence of different gingival colors on the color differences of laminate veneers.

Material And Methods: Five maxillary typodonts were used to obtain study models using 5 different gingival colors: light pink (LP), dark pink (DP), orange (Or), brown (Br), and violet (V).

Effect of preparation design and scan pattern on the accuracy of intraoral scans for complete arch laminate veneers under simulated intraoral variables.

Purpose: The purpose of the study was to investigate the influence of different preparation designs and scan patterns on the accuracy of intraoral scans for complete-arch maxillary laminate veneers.

Materials And Methods: Three maxillary typodonts were used to obtain reference models with three different laminate veneer preparation designs: windows (W), beveled (B), and incisal overlap (IO). Reference scans were obtained with a desktop scanner.

Pandemic of the century: COVID-19 in inflammatory rheumatic diseases of a national cohort with 3,532 patients.

Objectives: This study aimed to assess the clinical outcomes and risk factors for severe coronavirus disease 2019 (COVID-19) in patients with inflammatory rheumatic disease (IRD) of a national cohort.

Patients And Methods: The multicenter cross-sectional study was carried out between July 15, 2020, and February 28, 2021. Data collection was provided from a national network database system, and 3,532 IRD patients (2,359 males, 1,173 females; mean age: 48.

Unlocking the Potential of Rucaparib: A Case Series on Its Impact in Metastatic Breast Cancer With Mutations.

Triple-negative breast cancer poses distinct challenges because it lacks hormone receptors and does not have human epidermal growth factor receptor 2 (HER2) amplification. Mutations in BRCA1/2 genes are associated with homologous recombination deficiency tumors, rendering them susceptible to poly (ADP-ribose) polymerase (PARP) inhibitors. Notably, germline BRCA1/2 mutations are linked to distinct clinical features, including an increased risk of triple-negative breast cancer (TNBC) and a younger age of onset.

Predicting human and viral protein variants affecting COVID-19 susceptibility and repurposing therapeutics.

The COVID-19 disease is an ongoing global health concern. Although vaccination provides some protection, people are still susceptible to re-infection. Ostensibly, certain populations or clinical groups may be more vulnerable.

Synthesis and catalytic application of a donor-free bismuthenium cation.

Herein, we report the synthesis and catalytic application of a new ,'-dineopentyl-1,2-phenylenediamine-based bismuthenium cation (3). 3 has been synthesized the treatment of chlorobismuthane LBiCl [L = 1,2-CH{N(CHBu)}] (2) with AgSbF, and was further used as a robust catalyst for the cyanosilylation of ketones under mild reaction conditions. Experimental studies and DFT calculations were performed to understand the mechanistic pathway.

A comparative analytical study on outcome of secondary peritonitis using Mannheim's peritonitis index in geographically diverse Indian patients.

Objectives: Secondary peritonitis is caused by infection of the peritoneal cavity due to perforation of the alimentary tract. Mannheim's peritonitis ındex (MPI) is a prognostic scoring system that predicts outcomes in peritonitis. Increasing MPI scores correlate with poor outcomes and mortality.

Adsorption of crystal violet dye from synthetic wastewater by ball-milled royal palm leaf sheath.

The current study shows that using a batch approach to remove crystal violet dye from synthetic wastewater is feasible when using royal palm leaf sheath powder as an adsorbent. In order to investigate the effects of many parameters, including starting concentration, pH effect, dye concentration, adsorbent dose, contact time, and temperature, experiments were carried out under various operating conditions. Maximum removal was obtained at pH 6 and at a concentration of 100 ppm, which are considered as ideal values.

A microfluidic route for synthesis of scandium oxide microspheres, their characterization and neutron activation.

Radioactive scandium-46 microspheres have applications in mapping flow in a chemical reactor through a technique known as radioactive particle tracking (RPT). In the present study a novel microfluidic method has been developed for synthesis of controlled size scandium oxide microspheres. An inline/in-situ mixing of the scandium precursor and gelling agents was implemented which makes the microfluidic platform amenable for truly continuous operation.

Repression of does not contribute to the synthetic growth defect conferred by an -marked deletion of in a mutant.

Powers et al. recently demonstrated that the cassette used to delete in yeast mutants leads to reduced expression in of the adjacent gene encoding the mitochondrial small subunit (SSU) ribosomal protein Mrp51. Here we provide evidence that elimination of Dbp1, not reduced expression, underlies the synthetic growth defect of a mutant on glucose-containing medium, where respiration is dispensable, consistent with our previous conclusion that Dbp1 and Ded1 perform overlapping functions in stimulating translation initiation on mRNAs burdened with long or structured 5'UTRs in cells cultured with glucose.

The safety of ABO minor incompatible platelets transfusions using a rapid infuser.

Background: Administering platelets through a rapid infuser is proven to be safe. However, the clinical significance of infusing ABO-incompatible platelets with red blood cells (RBCs) in a rapid infuser remains unclear. There is a theoretical risk that isoagglutinin in the plasma of a platelet unit can interact with RBCs and induce hemolysis.

Anthropometric indexes for predicting high blood pressure in Turkish adults.

Purpose: It is controversial which anthropometric indexes are the best in predicting the risk of hypertension and how anthropometric measurements are related to blood pressure (BP). This study aimed to evaluate the relationship between BP and anthropometric indexes and to determine the best predictors for hypertension risk.

Methods: This cross-sectional study was conducted with 415 consecutive participants (161 men, mean age: 33.

Effect of non-thermal plasma treatment and resin cements on the bond strength of zirconia ceramics with different yttria concentrations.

Objectives: To investigate the effect of different surface treatments and resin cements on the shear bond strength of zirconia ceramics with different yttria concentrations.

Methods: Zirconia blocks characterized by different yttria concentrations [Vita YZ HT (HT), Vita YZ ST (ST) and Vita YZ XT (XT)] were used to prepare disc-shaped specimens (n=252). Specimens prepared to investigate shear bond strength (SBS), water contact angle and surface roughness (Ra) were divided into four subgroups; control (C), sandblasting (S), sandblasting + nonthermal plasma treatment (SNTP) and nonthermal plasma treatment (NTP).