We analytically derive the formulas of the threshold pump intensity and the range of possible detuning for the initiation of the pure quartic platicon (PQP) in the presence of multiphoton absorption, free-carrier absorption, and free-carrier dispersion. Theoretical investigations demonstrate a feasible approach for the excitation of PQP in the normal quartic dispersion regime via the free-carrier effects in platforms such as silicon, germanium, and their derivates. Due to the time-variant nonlinear loss related to free-carrier absorption or additional nonlinear detuning induced by free-carrier plasma dispersion, PQP can be generated through turn-key or laser frequency scanning schemes in both the three- and four-photon absorption regimes.
View Article and Find Full Text PDFWe synthesized MgO NPs via sol-gel reaction and investigated them as carriers to deliver Mg to the affected joint for osteoarthritis (OA). The physicochemical properties of samples were characterized by transmission electron microscope (TEM), dynamic light scattering (DLS) and x-ray diffraction (XRD). The release of Mg was monitored by ICP-MS.
View Article and Find Full Text PDFThis study presents an innovative cloud-based approach, using Pixian Douban, a well-known Chinese fermented seasoning, as a case study, to improve the identification of umami peptides and explore their interactions with the T1R1/T1R3 receptor. A feature-based molecular networking method was utilized to rapidly identify a total of eighteen peptides, including seven previously unrecorded ones. Notably, the umami threshold of QIVK in an aqueous solution was determined to be 0.
View Article and Find Full Text PDFWe numerically investigate the excitation of vector solitonic pulse with orthogonally polarized components via free-carrier effects in microresonators with normal group velocity dispersion (GVD). The dynamics of single, dual and oscillated vector pulses are unveiled under turn-key excitation with a single frequency-fixed CW laser source. Parameter spaces associated with detuning, polarization angle, interval between the pumped orthogonal resonances and pump amplitude have been revealed.
View Article and Find Full Text PDFPeriodically arranging coordination-distinct actinides into one crystalline architecture is intriguing but of great synthetic challenge. We report a rare example of a heterobimetallic actinide metal-organic framework (An-MOF) by a unique reaction-induced preorganization strategy. A thorium MOF (SCU-16) with the largest unit cell among all Th-MOFs was prepared as the precursor, then the uranyl was precisely embedded into the MOF precursor under oxidation condition.
View Article and Find Full Text PDFThe unique flavor of Pixian douban (PXDB) is widely acknowledged to be associated with its maturation process. However, there is limited knowledge about the non-volatile metabolites that contribute to this flavor. To bridge this gap, this study employed a metabolomics approach and a feature-based molecular network (FBMN) analysis to investigate the non-volatile metabolite fingerprints of PXDB during its two-year maturation process.
View Article and Find Full Text PDFZhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
September 2022
Objective: To review the research progress regarding the over-the-top technique for anterior cruciate ligament (ACL) reconstruction.
Methods: The relevant literature on ACL reconstruction using the over-the-top technique was analyzed for its evolution, clinical application, advantages, and limitations.
Results: Over-the-top technique for ACL reconstruction is a combined intra- and extra-articular technique.
Targeted cancer therapies using immunotoxins have achieved remarkable efficacy in hematological malignancies. However, the clinical development of immunotoxins is also faced with many challenges like anti-drug antibodies and dose-limiting toxicity issues. Such a poor efficacy or safety ratio is also the major hurdle in the research and development of antibody-drug conjugates.
View Article and Find Full Text PDFIn the initial step of sugar metabolism, sugar-specific transporters play a decisive role in the passage of sugars through plasma membranes into cytoplasm. The SecY complex (SecYEG) in bacteria forms a membrane channel responsible for protein translocation. The present work shows that permeabilized SecY channels can be used as nonspecific sugar transporters in Escherichia coli.
View Article and Find Full Text PDFTheaflavin (TF), which is the key pigment in black tea, is a health-promoting food component with beneficial effects on humans. However, the interactions by which these effects are transferred and exerted into protein-rich foods are unclear. Here, egg ovalbumin (OVA) was selected as a representative dietary protein to ascertain their binding mechanism.
View Article and Find Full Text PDFA computational fluid dynamics model of a bicuspid aortic valve has been developed using idealised three-dimensional geometry. The aim was to compare how the orifice area and leaflet orientation affect the hemodynamics of a pure bicuspid valve. By applying physiologic material properties and boundary conditions, blood flow shear stresses were predicted during peak systole.
View Article and Find Full Text PDFBackground: Consolidated bioprocessing (CBP), integrating cellulase production, cellulose saccharification, and fermentation into one step has been widely considered as the ultimate low-cost configuration for producing second-generation fuel ethanol. However, the requirement of a microbial strain able to hydrolyze cellulosic biomass and convert the resulting sugars into high-titer ethanol limits CBP application.
Results: In this work, cellulolytic yeasts were developed by engineering Saccharomyces cerevisiae with a heterologous cellodextrin utilization pathway and bifunctional minicellulosomes.
Interface atom migration and compositional evolution during the heterostructure nanojoining process under external electrical loadings has been investigated in situ inside a transmission electron microscope with atomic resolution. The results indicate that the migration of oxygen atoms on the contact interface of metal nanorods is a thermal dominated process rather than an electromigration process. After removing the oxide layer at the nanometal contact interface, the metal atoms migrate under external electrical field.
View Article and Find Full Text PDFJ Colloid Interface Sci
March 2005
In this work, well-crystallized and well-dispersed rod-like TiO(2) rutile particles were prepared by hydrothermally treating acid-peptized TiO(2) sols at relatively low temperatures of 200 and 240 degrees C. Raman spectra, transmission electron microscopy (TEM), and X-ray diffraction (XRD) were used to characterize the peptized sols before and after hydrothermal treatment. The results showed that HNO(3) peptization of amorphous TiO(2) was able to promote, at room temperature, the formation of crystalline phases of anatase or rutile, at low (HNO(3)/Ti=1) or at high (HNO(3)/Ti=4) concentrations of peptizer, respectively.
View Article and Find Full Text PDFJ Colloid Interface Sci
April 2003
Weakly flocculated aqueous anatase suspensions were prepared in situ by hydrothermally treating amorphous titania particles peptized with different amounts of tetraethylammonium hydroxide (TENOH). The simultaneous formation of hydrous TiO2 polyanions in the presence of OH- and tetraethylammonium cations are two essential conditions for the peptization process to occur. The absence of either of these conditions will cause reprecipitation.
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