Real-World Outcomes of Pyrotinib-Based Therapy for HER2-Positive Breast Cancer With Brain Metastases: A Multicentre, Retrospective Analysis.

Objective: This study was designed to investigate the efficacy and safety of pyrotinib-based therapy for HER2-positive breast cancer with brain metastases (BM) in the real-world setting.

Methods: Data of HER2-positive breast cancer patients with BM treated with pyrotinib-based therapy from a multicetre, registered, real-world study were analyzed.

Results: Among 45 female patients, the overall objective response rate (ORR) was 62.

Palladium-Catalyzed Bicycloaromatization of -(Alkynyl)styrenes with Alkynes: Economical Access to Chrysene Derivatives.

Herein, a palladium-catalyzed bicycloaromatization of -(alkynyl)styrenes with alkynes is reported. In this protocol, the 6-- cyclization of -(alkynyl)styrenes is followed by deprotonation to complete the first cycloaromatization, and then, a regioselective alkyne insertion/C-H activation occurs to achieve the second cycloaromatization, resulting in atom- and step-economical syntheses of polysubstituted chrysenes. Notably, the products can be further used to construct π-extended arenes using the Scholl reaction.

Global burdens of nasopharyngeal carcinoma in children and young adults and predictions to 2040.

Objectives: To investigate the epidemiological trend for nasopharyngeal carcinoma among children and young adults and the disease burden they caused.

Materials And Methods: Data were collected from the Global Burden of Disease (GBD) study 2019. A comprehensive analysis was performed, with age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), disability-adjusted life-years (DALYs) and estimated annual percentage changes (EAPC).

Site of left axillary vein crossing the clavicle: an analysis with computed tomography venography as a guide for vein puncture for device implantation.

Background: Blind axillary venous access is a convenient but technically difficult approach for cardiac rhythm device lead implantation. We try to explore whether there are rules on the axillary vein course to facilitate blind venous cannulation.

Methods: In a single-center, retrospective study, we included 155 patients who underwent computed tomography venography (CTV) examination of left axillary vein.

Clinical Evaluation of the Medium-Term Efficacy of Laparoscopic Sleeve Gastrectomy against Obstructive Sleep Apnea-Hypopnea Syndrome in Obese Patients.

Objective: This study was designed to evaluate the efficacy of laparoscopic sleeve gastrectomy (LSG) for obstructive sleep apnea-hypopnea syndrome (OSAHS) in obese individuals and identify the related factors affecting its efficacy.

Methods: The clinical and follow-up data of 37 obese patients with OSAHS who underwent LSG in the Laparoscopic Surgery Department of Zibo Central Hospital from January 2017 to July 2018 were analyzed retrospectively. The effect of this operation on patients' weight and OSAHS was studied, and the factors affecting weight and OSAHS were examined through univariate and multivariate logistic regression analysis.

SKA3 promotes glioblastoma proliferation and invasion by enhancing the activation of Wnt/β-catenin signaling via modulation of the Akt/GSK-3β axis.

Spindle and kinetochore-related complex subunit 3 (SKA3) is a key modulator of the progression of multiple tumor types. However, the involvement of SKA3 in glioblastoma (GBM) has not been well studied. The current study aimed to explore the role of SKA3 expression and the potential function of the protein in GBM.

Effect of Preoperative Nutritional Risk Screening on Postoperative Recovery in Patients with Laparoscopic-Assisted Radical Resection for Colorectal Cancer.

Results: There were statistically significant differences in BMI, albumin, total cholesterol, and lymphocyte count between patients from the two groups (all < 0.05). There was no difference in the incidence rate of postoperative complications between the two groups, but there was a statistically significant difference in the total number of complications ( < 0.

Incidence and predictors of left atrial thrombus in patients with atrial fibrillation prior to ablation in the real world of China.

Background: The present study was to evaluate the value of CHADS2 and CHA2DS2VASC scores on predicting left atrial (LA) or left atrial appendage (LAA) thrombus in atrial fibrillation (AF) patients prior to ablation in the real world of China.

Methods And Results: A total of 397 patients with non-valvular AF were analyzed to determine the relationship between CHADS2 and CHA2DS2VASC scores and LA/LAA thrombus identified on transesophageal echocardiography prior to radiofrequency ablation(RFA). LA/LAA thrombus was present in 38 patients (9.

Spontaneous scar-based reentrant atrial flutter: Electrophysiologic characteristics and ablation outcome in a retrospective analysis.

Background: The understanding of spontaneous scar-based reentrant atrial arrhythmia is limited. We aim to characterize the electrophysiologic and mapping features of spontaneous scar-based atrial flutter (AFL) and outcomes of catheter ablation.

Methods: Consecutive patients with a diagnosis of AFL who underwent catheter ablation from January 2012 to June 2015 were screened.

A Simple Method to Differentiate Atrioventricular Node Reentrant Tachycardia from Orthodromic Reciprocating Tachycardia.

Discrimination between atrioventricular node reentry tachycardia (AVNRT) and orthodromic reciprocating tachycardia (ORT) during an electrophysiological study is sometimes challenging. This study aimed to investigate if the difference in the local VA (ventricle-atrium) interval during ventricular entrainment pacing and during tachycardia (DVA, defined as the shortest local VA interval of coronary sinus [CS] during entrainment minus the shortest local VA interval of CS during tachycardia) was different in patients with AVNRT and patients with ORT.Diagnoses of AVNRT or ORT through a concealed accessory pathway (AP) were made according to conventional electrophysiological criteria and ablation results.

Frequency spectra analysis suggests outcomes in patients with paroxysmal atrial fibrillation.

Background And Aim: The purpose of this study was to determine the role of dominant frequency (DF) and organised index (OI) in outcomes of pulmonary vein (PV) isolation for paroxysmal atrial fibrillation (AF).

Methods: OI and DF of electrograms in coronary vein (CS) during AF were obtained by frequency spectra analysis in 60 patients with paroxysmal AF who underwent PV isolation. Based on the results of 12 months follow up, 14 patients with recurrent AF were included in group 1 and 46 patients with sinus rhythm were included in group 2.

Effect of fat pad ablation on the spatial and temporal stability of complex fractionated atrial electrogram in acetylcholine-induced atrial fibrillation.

Objective: The objective of this study was to investigate the effect of selective fat pad ablation on the spatial and temporal stability of the complex fractionated atrial electrogram (CFAE) in acetylcholine (ACh)-induced atrial fibrillation (AF).

Methods And Results: ACh was applied to fat pads in 10 dogs. Effective refractory periods (ERPs) at 5 different sites, AF inducibility and AF duration were obtained before and after fat pad ablation.

Different properties of complex fractionated atrial electrograms during atrial fibrillation.

Aims: The aim of the present study was to investigate various properties of complex fractionated atrial electrograms (CFAEs) in different models of atrial fibrillation.

Methods: Fifteen dogs were divided into three groups (five dogs/group): group 1 (pacing-induced atrial fibrillation group), group 2 (100 mM Ach-induced atrial fibrillation group), group 3 (500 mM Ach-induced atrial fibrillation group). Five sites from the left atrium in each dog were used as recording sites.

Prediction of sudden cardiac death in patients after acute myocardial infarction using T-wave alternans: a prospective study.

Background And Purpose: We assessed the value of T-wave alternans (TWA) in prediction of sudden cardiac death (SCD) in patients with acute myocardial infarction (AMI).

Methods: Consecutive patients (N = 227) were enrolled and were monitored with 24-hour ambulatory electrocardiogram within 1 to 15 days after AMI. T-wave alternans was identified by a modified moving average (MMA) algorithm computer software.

Electrophysiological characteristics of the Marshall potential in dogs.

Background: The electrophysiological characteristics of the Marshall potential is important in ligament of Marshall (LOM) ablation.

Methods And Results: Marshall potential was recorded under sinus rhythm and left atrial appendage (LAA) pacing and in the first randomly selected 5 dogs (Group 1), LOM ablation was performed. Histological examination was performed in the remaining 10 dogs, which were subdivided according to the results (Groups 2, 3).