Comparative evaluation of A1A2 and A2A2 cow milk-containing diets on biochemical and histological parameters of Wistar rats.

This Research Communication aims to compare the effect of A1A2 and A2A2 cow milk diets on the biochemical and histological parameters of rats. The rats were divided into four groups and fed with a normal diet, A2 milk powder, A1A2 or A2A2 cow milk diets for 90 d. Blood glucose, kidney function, liver function and lipid profile were examined during the experimental period.

Nanoparticle formulations: A smart era of advanced treatment with nanotoxicological imprints on the human body.

In the modern era, nanoparticles are the preferred dosage form, and maximum research is going on in the field of nanoparticle formulations. But as they are so small, nanoparticles are able to slip through the body's defenses and cause damage to the organs and tissues deep inside. In recent years, most researchers have focused solely on the therapeutic value of drugs or, at times, the performance of dosage forms, but few have given toxicity studies equal weight in their research.

Formulation and evaluation of SGLT2 inhibitory effect of a polyherbal mixture inspired from Ayurvedic system of medicine.

Background And Aim: The ingredients viz., and of the present formulation are used to treat diabetes in the Indian traditional medical system. Adopting the concept of multiple herbal mixtures for better therapeutic effects from the ancient Ayurvedic text Sarangdhar Samhita, the present study aimed to develop a polyherbal formulation (PHF) of seven herbs and to evaluate its sodium-glucose cotransporter protein-2 (SGLT2) inhibitory effect on type 2 diabetic rats.

Recent advances in immunotoxicity and its impact on human health: causative agents, effects and existing treatments.

Background: A strong immune system is a primary requirement to keep the body safe from different ailments and infections. A human knowingly or unknowingly often comes to the exposure of many foreign substances such as pollutants, chemicals, metals and drugs that affect the immune system. Though some of these substances are known to exert immunotoxicity, their precise role as immunotoxicant is still unidentified, hence, the testing of these substances has to be taken into account.

Recent Developments and Potential for Clinical Use of Casein as a Drug Carrier.

Background: The development of drug delivery carriers is the key area of research in the field of novel drug delivery systems. To date, a long list of carriers has been identified for this purpose but the deliveries of poorly water-soluble active substances are still facing challenges and hence, such substances are pharmacologically unsafe and economically incompetent.

Objective: This article aims to review the applications of casein as a drug carrier and its potential for clinical use.

Modulation of gut microbiota with Ayurveda diet and lifestyle: A review on its possible way to treat type 2 diabetes.

Background: The prevalence of type 2 diabetes (T2D) has increased substantially in the past few decades throughout the world. In India, the epidemic of diabetes continues to increase irrespective of area, status, and age. Despite various scientific societies involved in the treatment of diabetes, still, the burden of diabetes keeps growing.

Correction: Pd-catalyzed annulation of imidazo[1,2-]pyridines with coumarins and indoles: synthesis of benzofuran and indole fused heterocycles.

Correction for 'Pd-catalyzed annulation of imidazo[1,2-]pyridines with coumarins and indoles: synthesis of benzofuran and indole fused heterocycles' by Rashmi Semwal , , 2022, , 1585-1588, DOI: 10.1039/D1CC06803B.

Pd-catalyzed annulation of imidazo[1,2-]pyridines with coumarins and indoles: synthesis of benzofuran and indole fused heterocycles.

Palladium-catalyzed annulation of imidazo[1,2-]pyridines with coumarins provided benzofuran fused transannulated products in good to excellent yields a decarbonylative approach, while imidazo[1,2-]pyridines with -methyl indoles in the presence of palladium and base yielded conjugated imidazopyridine fused indole derivatives. Additional experiments revealed that the presence of the phenyl ring at the C-2 position of imidazo[1,2-]pyridines is essential for the annulation than the alkyl groups. Both transformations follow the ionic mechanism by Pd-catalyzed double C-H bond activation.

Emodin - A natural anthraquinone derivative with diverse pharmacological activities.

Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a natural anthraquinone derivative that is present in numerous globally renowned herbal medicines. It is recognised as a protein tyrosine kinase inhibitor and as an anticancer drug, active against various tumour cells, including lung, breast, liver, and ovarian cancer cells. Recently, its role in combination chemotherapy with various allopathic medicines, to minimize their toxicity and to enhance their efficacy, has been studied.

Antidiabetic effect of aqueous-ethanol extract from the aerial parts of .

is used for the management of diabetes mellitus in the Indian subcontinent. The present work aimed to validate the traditional claim of the plant in diabetes mellitus. studies were conducted using α-glucosidase and α-amylase assays whereas streptozotocin-nicotinamide-induced diabetic Wistar rats were used for study.

HumDLoc: Human Protein Subcellular Localization Prediction Using Deep Neural Network.

Aims: To develop a tool that can annotate subcellular localization of human proteins.

Background: With the progression of high throughput human proteomics projects, an enormous amount of protein sequence data has been discovered in the recent past. All these raw sequence data require precise mapping and annotation for their respective biological role and functional attributes.

Protective and therapeutic effects of natural products against diabetes mellitus via regenerating pancreatic β-cells and restoring their dysfunction.

Diabetes mellitus is a growing public health concern and an increasing interest has been raised to search for new compounds with therapeutic effects on β-cells. There are chronic insulin resistance and loss of β-cell mass in the case of type-2 diabetes which covers about 90% of total diabetic patients. This work aims to critically review the protective and regenerative effects of various antidiabetic natural products on pancreatic β-cells.

DeepOlf: Deep Neural Network Based Architecture for Predicting Odorants and Their Interacting Olfactory Receptors.

Olfaction transduction mechanism is triggered by the binding of odorants to the specific olfactory receptors (OR's) present in the nasal cavity. Different odorants stimulate different OR's due to the difference in shape, physical and chemical properties. In this paper, a deep neural network architecture DeepOlf, based on molecular features and fingerprints of odorants and ORs, to predict whether a chemical compound is a potential odorant or not along with its interacting OR is proposed.

Pr[m]: An Algorithm for Protein Motif Discovery.

Motifs are the evolutionarily conserved patterns which are reported to serve the crucial structural and functional role. Identification of motif patterns in a set of protein sequences has been a prime concern for researchers in computational biology. The discovery of such a protein motif using existing algorithms is purely based on the parameters derived from sequence composition and length.

identification of therapeutic compounds against microRNA targets in drug-resistant pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is a major health issue that has been eluding efforts to identify viable therapeutic treatment options. Besides having the lowest survival rate among all types of cancer, almost all conventional methods of treatment are futile against this condition, leaving patients to succumb to this ailment faster than ever. As it is increasingly becoming difficult to come up with new compounds for the treatment of various diseases, alternative solutions are required for tackling these problems.

DeEPn: a deep neural network based tool for enzyme functional annotation.

With the advancement of high throughput techniques, the discovery rate of enzyme sequences has increased significantly in the recent past. All of these raw sequences are required to be precisely mapped to their respective functional attributes, which helps in deciphering their biological role. In the recent past, various prediction models have been proposed to predict the enzyme functional class; however, all of these models were able to quantify at most six functional enzyme classes ( to ) out of existing seven functional classes, making these approaches inappropriate for handling enzymes corresponding to the seventh functional class ().

Comparative modeling and structure based drug repurposing of PAX2 transcription factor for targeting acquired chemoresistance in pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is a pancreatic malignancy suffering from poor prognosis; the worst among all types of cancer. Chemotherapy, which is the standard regime for treatment in most cases, is often rendered useless as drug resistance quickly sets in after prolonged exposure to the drug. The implication of PAX2 transcription factor in regulating several ATP-binding cassette (ABC) transporter proteins that are responsible for the acquisition of drug resistance in PDAC makes it a potential target for treatment purposes.

Author Correction: Identification of novel dysregulated key genes in Breast cancer through high throughput ChIP-Seq data analysis.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

An integrated epigenome and transcriptome analysis identifies PAX2 as a master regulator of drug resistance in high grade pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is notoriously difficult to treat due to its aggressive, ever resilient nature. A major drawback lies in its tumor grade; a phenomenon observed across various carcinomas, where highly differentiated and undifferentiated tumor grades, termed as low and high grade respectively, are found in the same tumor. One eminent problem due to such heterogeneity is drug resistance in PDAC.

Formulation and Evaluation of Polyherbal Cream and Lotion for the Treatment of Psoriasis-Induced Secondary Infections.

Background: Psoriasis is one of the most common skin diseases in humans and affects a major population worldwide. The aim of the present study is to evaluate the efficacy of selected polyherbal formulations against psoriasis-induced secondary infections.

Aim: Psoriasis is one of the most common skin diseases in humans and affects a major population worldwide.

A Molecular Approach on the Protective Effects of Mangiferin Against Diabetes and Diabetes-related Complications.

Background: Diabetes and its related complications are now a global health problem without an effective therapeutic approach. There are many herbal medicines which have attracted much attention as potential therapeutic agents in the prevention and treatment of diabetic complications due to their multiple targets.

Aim: The aim of this study is to review available knowledge of mangiferin focusing on its mode of action.

Copper-Catalyzed Multicomponent Reactions (MCRs) for Disulfenylation of Imidazo[1,2-]pyridines Using Elemental Sulfur and Arylhalides and Intramolecular Cyclization of Haloimidazo[1,2-]pyridines.

Copper-catalyzed synthesis of disulfenylated imidazo[1,2-]pyridines and indoles using elemental sulfur and haloarenes through one-pot, three component reaction by two C-S-C bond formations has been developed. The method has a broad substrate scope with a variety of substituted haloarenes. The conditions were also applied for the synthesis of benzothieno-imidazo[1,2-]pyridines in excellent yields (99%) through intramolecular sulfenocyclization of 2-(2-halophenyl)imidazo[1,2-]pyridines using sulfur powder.

Pd-Catalyzed regioselective synthesis of 2,6-disubstituted pyridines through denitrogenation of pyridotriazoles and 3,8-diarylation of imidazo[1,2-a]pyridines.

Synthesis of 2,6-disubstituted pyridines from pyridotriazoles through palladium-catalyzed aerobic oxidative denitrogenative reactions has been described. Denitrogenation of arylated pyridotriazoles generates metal-carbene intermediates in situ and provides selectively 6-aryl-2-benzoylpyridines. The same conditions have been extended to regioselective C-3 and C-8 diarylation of several imidazo[1,2-a]pyridines.

: A Plant Used in Traditional Medicine and Its Potential for Clinical Uses.

(Roxb.) Jessop (Asparagaceae) is a reputed Ayurvedic medicine for a number of therapeutic benefits, including for cardiac diseases, indigestion, asthma, dropsy, rheumatism, leprosy, and skin ailments. The present work aimed to critically and extensively review its traditional uses, phytochemistry, pharmacology, toxicology, and taxonomy together with the mechanisms of action of selected extracts of .