Publications by authors named "Semra Akkaya Turhan"
Article Synopsis
- The study aimed to assess the reliability and validity of the Turkish translation of the 5-item Dry Eye Questionnaire (T-DEQ-5) and compare it with other eye tests and a similar questionnaire called OSDI.
- The research involved a series of linguistic validation steps, and results showed that the T-DEQ-5 had excellent test-retest reliability (0.95) and strong internal consistency (Cronbach's alpha of 0.90).
- The T-DEQ-5 effectively distinguished dry eye patients, showing high sensitivity (81%) and specificity (91%) when compared to the OSDI and other diagnostic tests.
Article Synopsis
- The study compared the effects of conventional and accelerated corneal crosslinking (CXL) on various eye health metrics in patients with progressive keratoconus.
- Both treatment methods showed improvement in keratometric values and epithelial thickness after 6 months, but some epithelial thickness indices were reduced at 1 month post-surgery.
- Accelerated CXL resulted in quicker recovery of corneal nerve density compared to conventional CXL, highlighting its potential advantages in nerve regeneration.
Article Synopsis
- - The study investigates the presence of axonal spheroids in motor axons and C-fibers of patients with amyotrophic lateral sclerosis (ALS) using corneal confocal microscopy and skin biopsies.
- - It involved 31 ALS patients and 20 healthy subjects, measuring various nerve fiber metrics and dendritic cell density, revealing that ALS patients had more axonal spheroids and higher dendritic cell density compared to controls.
- - The findings suggest that analyzing dendritic cells and axonal structures in ALS patients may help understand the disease's mechanisms and identify potential biomarkers for diagnosis or monitoring.
Intraocular foreign body in the anterior chamber angle misdiagnosed as herpetic stromal keratitis.
Ulus Travma Acil Cerrahi Derg
July 2023
Article Synopsis
- * Initial examinations revealed corneal edema and lens opacification, leading to further imaging that confirmed the presence of the foreign body despite no reported history of trauma.
- * After surgical removal of the IOFB, the patient achieved excellent visual recovery, highlighting the need for awareness about eye protection and considering IOFB in similar ocular cases, especially for those in high-risk occupations.
Article Synopsis
- This study aimed to compare the effects of two blepharoplasty techniques—skin-only resection and skin-plus-orbicularis muscle resection—on corneal nerves and eye health in patients with dry eye disease (DED).
- Results showed that there was a temporary decrease in corneal nerve density immediately after surgery for both techniques, but these parameters returned to baseline levels by one month post-op.
- Both surgical methods led to increased meibomian gland atrophy after one year, but changes in eyebrow height were only significant in the group that had the orbicularis muscle removed, suggesting minimal long-term differences in eye health outcomes between the two techniques.
Article Synopsis
- Chronic inflammatory demyelinating polyneuropathy (CIDP) involves myelin-related issues, small fiber neuropathy (SFN), and axonal degeneration, contributing to severe symptoms and reduced quality of life.
- In vivo corneal confocal microscopy (IVCCM) offers a non-invasive method to study small fiber damage in CIDP patients, with 15 patients assessed alongside 32 healthy controls.
- Results revealed significantly lower corneal nerve fiber density and length in CIDP patients, indicating the potential role of IVCCM as a biomarker for understanding and evaluating this condition.
Article Synopsis
- * Conducted with 58 MS patients (split into relapse and remission groups) and 30 healthy controls, IVCCM assessed various nerve parameters, revealing significant differences between MS patients and controls but no notable differences between the relapse and remission groups.
- * Follow-up IVCCM tests on relapse patients showed an increase in specific corneal nerve measurements, indicating potential changes during disease recovery, even though overall comparisons between relapse and remission did not show significance.
Article Synopsis
- The study aimed to explore nerve fiber damage and inflammation in the corneas of severely obese individuals compared to healthy subjects.
- It involved 28 severely obese patients (half of whom were prediabetic or diabetic) and 20 healthy individuals, using a specialized imaging technique to measure various nerve fiber parameters.
- Findings indicated that the obese group had significantly lower nerve fiber density and increased inflammation compared to the control group, suggesting obesity could independently increase the risk for nerve damage.
Article Synopsis
- The study aimed to evaluate how changes in body mass index (BMI) and central fat distribution (CFD) after bariatric surgery affect eye refractive errors one year post-surgery.
- Researchers analyzed data from 37 patients, focusing on various measurements including BMI, CFD, and refractive status among other ocular parameters.
- Results indicated significant reductions in both BMI and CFD were associated with improved refractive errors in patients, suggesting bariatric surgery can influence eye health and should be monitored for refractive changes.
Article Synopsis
- A case report described a 38-year-old woman who developed crystalline keratopathy after her eye was exposed to Dieffenbachia plant sap, leading to symptoms like redness and blurred vision.
- Initial examinations showed punctate corneal erosions and specific needle-like crystals, which were diagnosed using in vivo corneal confocal microscopy (IVCCM).
- After treatment with antibiotics and artificial tears, the patient's condition improved significantly, and her vision returned to normal, highlighting the importance of immediate saline irrigation and the efficacy of IVCCM in identifying plant-related eye injuries.
Article Synopsis
- This study aimed to investigate corneal changes in patients with interstitial cystitis (IC), focusing on how it affects corneal sensation and nerve fiber density.
- Thirty IC patients and thirty-two healthy controls were examined, with tests for corneal sensation, tear breakup time, and nerve fiber analysis using in vivo corneal confocal microscopy.
- Results showed that IC patients had higher corneal sensation but lower nerve fiber density compared to healthy controls, suggesting that changes in nerve fibers might contribute to increased sensitivity and potential long-term sensitization.
Corneal neuropathic pain in irritable bowel syndrome: clinical findings and in vivo corneal confocal microscopy.
Graefes Arch Clin Exp Ophthalmol
October 2021
Article Synopsis
- - The study aimed to explore ocular discomfort and corneal changes in patients with irritable bowel syndrome (IBS), noting that ocular discomfort is common in central sensitization syndromes.
- - Researchers compared 29 IBS patients with 37 healthy controls regarding ocular surface discomfort, finding significant differences with higher discomfort scores and reduced tear break-up time in IBS patients, although corneal sensation remained unchanged.
- - Results showed that IBS patients experienced more dry eye symptoms and had reduced corneal nerve fiber density, indicating nerve damage, highlighting the need to consider IBS when assessing ocular discomfort in patients.
Article Synopsis
- The study aimed to compare the visual acuity, contrast sensitivity, spectacle needs, photic phenomena, and quality of life between patients receiving either low add multifocal (MIOL) or extended depth of focus (EDOF) intraocular lenses.
- Patients were randomly assigned to receive either type of lens and were evaluated postoperatively at 1, 3, and 6 months using various tests for visual performance and quality of life.
- Results indicated that the EDOF group had better visual performance at intermediate and near distances compared to the MIOL group, especially between -0.50 and -1.75 D, while photic phenomena and contrast sensitivity were similar between the two groups at the
Article Synopsis
- The study aims to detect early signs of neuropathy in type 2 diabetes patients using in vivo corneal confocal microscopy (IVCCM), focusing on those without diabetic retinopathy or peripheral neuropathy.
- It involved 60 type 2 diabetes patients (30 with microalbuminuria and 30 without) and 30 healthy controls, evaluating nerve parameters and other health indicators.
- Results showed significant reductions in nerve fiber length and density in diabetic patients compared to controls, suggesting that nerve damage can occur early and may help in preventing severe complications from diabetes.
Article Synopsis
- - This study examined the prevalence of psychiatric disorders in 94 patients with keratoconus, finding that 37.2% had a psychiatric diagnosis, with notable levels of moderate-severe depression (13.8%) and anxiety (21.2%).
- - The research highlighted a correlation between the severity of keratoconus and the likelihood of psychiatric disorders, with more severe cases linked to worse mental health outcomes.
- - Although patients with psychiatric diagnoses reported lower quality of life in several areas of the Short Form-36, the presence of a psychiatric disorder did not significantly influence their scores on the NEI-RQL-42, which measures vision-related quality of life.
Article Synopsis
- The study aimed to evaluate the visual performance and fit of a mini-scleral lens in patients with keratoconus using optical coherence tomography (OCT).
- A total of 29 eyes from 24 patients were fitted with the lens, showing significant improvements in both high- and low-contrast visual acuity after lens wear compared to best spectacle correction.
- Patients reported high levels of comfort, vision satisfaction, and overall satisfaction with the lens, and OCT effectively assessed the lens fit parameters like clearance and alignment.
Daily Disposable Contact Lens use in Adolescents and its Short-term Impact on Self-Concept.
Cont Lens Anterior Eye
October 2021
Article Synopsis
- The study investigates how wearing contact lenses affects the self-concept of adolescents over a month, using a modified self-concept scale to analyze results.* -
- In the trial, 21 adolescents, average age 16.5, were prescribed daily disposable contact lenses and reported high satisfaction (95%) despite experiencing dissatisfaction with spectacles prior to the trial.* -
- While some self-concept scores improved slightly, these changes were statistically insignificant, suggesting that contact lenses may still be beneficial for adolescents despite no major short-term self-concept gains.*
The purpose of this study was to investigate the effect of high molecular weight hyaluronan (HMWHA) eye drops on subbasal corneal nerves in patients suffering from severe dry eye disease (DED) and to evaluate the damage of subbasal corneal nerves associated with severe DED. Designed as an international, multicenter study, 16 patients with symptoms of at least an Ocular Surface Disease Index (OSDI) score of 33, and corneal fluorescein staining (CFS) of at least Oxford grade 3, were included and randomized into two study arms. The control group continued to use their individual optimum artificial tears over the study period of eight weeks; in the verum group, the artificial tears were substituted by eye drops containing 0.
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- The study evaluated reading performance and spectacle independence in patients with two types of intraocular lenses (IOLs) implanted after cataract surgery: a low add multifocal and an extended depth of focus (EDOF) IOL.
- Results showed that patients with the EDOF IOL (Symfony group) had better near visual acuity and preferred closer reading distances compared to those with the low add multifocal IOL (Tecnis + 2.75 group).
- Both groups reported similar levels of independence from spectacles for near activities, with about 14.3% in the Symfony group and 26.7% in the Tecnis + 2.75 group occasionally needing glasses for near tasks.
Article Synopsis
- The study aimed to compare the effectiveness and safety of accelerated corneal cross-linking (CXL) versus conventional CXL in young patients with keratoconus.
- A total of 48 eyes were treated, with results showing significant improvements in keratometric values for both groups, but no notable changes in visual acuity or refractive errors.
- Both methods effectively stabilized keratoconus progression, with accelerated CXL offering a quicker treatment option for pediatric patients.
Article Synopsis
- The study assessed how corneal epithelial thickness and curvature change throughout the day and the impact of wearing daily disposable soft contact lenses.
- Researchers conducted tests on 32 healthy volunteers, measuring corneal thickness and curvature both in the morning and after eight hours of lens wear using advanced imaging techniques.
- Results showed that natural variations in corneal curvature occurred without lens wear, while wearing contact lenses did not significantly affect corneal thickness or curvature, suggesting lenses might mask natural changes.
Article Synopsis
- The study aimed to assess how changes in the optical density of fluid behind miniscleral lenses affect vision quality and comfort over time in patients with keratoconus.
- Thirteen patients were fitted with miniscleral lenses, and various visual acuity measurements and comfort levels were recorded before and after lens wear, showing significant improvements in high-contrast visual acuity but a decline in low-contrast visual acuity after two hours.
- Results indicated that while high-contrast visual performance remained stable, the optical density of the fluid increased over time, negatively impacting low-contrast vision, suggesting a need for monitoring fluid changes during lens wear.
Article Synopsis
- * Twelve eyes from 10 patients were analyzed, revealing that repeated CXL helped stabilize keratoconus in most eyes after surgery, with no complications observed.
- * Results showed that while uncorrected and corrected visual acuity stayed the same, Kmax (the measure of the cornea's steepness) improved in 8 eyes, highlighting the potential need for follow-up monitoring for at least 2 years post-primary CXL.
Article Synopsis
- The study aimed to evaluate corneal thickness changes in patients with progressive keratoconus undergoing accelerated corneal collagen crosslinking (CXL) using an isotonic riboflavin solution with different eyelid treatments.
- Fifty-two eyes from 48 patients were divided into two groups: one with eyelid speculum removal and the other with the speculum retained during the riboflavin instillation and CXL procedure.
- Results indicated that eyelid closure during riboflavin application significantly enhanced corneal thickness, suggesting it may improve safety during the CXL procedure, especially for patients with thinner corneas.