[Experience with simvastatin therapy for the achievement of osteoprotective effects in women with hyperlipidemia].

The aim of the work was to study the influence of statins on the functional and metabolic state of bone tissue during correction of type IIA and IIB hyperlipidemia in women with osteopenia. 53 of the 83 patients aged 45-50 years were treated with statins (20 mg/d) and low-fat diet. Bone mineral density (BMD) was measured in the lumbar spine region (LII-LIV) and femoral neck by DEXA.

[Biochemical and immunological markers of osteoporosis in patients with chronic obstructive pulmonary disease].

A cytokine profile and changes in bone metabolism were studied in 95 patients (30 females and 65 males) with chronic obstructive pulmonary disease (COPD). Subnormal bone density was diagnosed in 78% patients with COPD. Frequency of osteoporosis discovery in emphysema was higher than in chronic obstructive bronchitis and the degree of density loss in bone tissue depended on ventilation disturbance.

[The macrolide antibiotic rovamycin in the treatment of pneumonias].

A clinical trial was made of the efficacy of macrolide antibiotic rovamycin (spiromycin) in 30 patients (mean age 35 +/- 12 years) with moderate extrahospital pneumonia. In group I (12 patients) with affection of at least 2 lung segments rovamycin was intravenously infused for 3 days (3,000,000 IU 2 times a day), then given orally for 5 days (3,000,000 IU 2 times a day every 12 hours). 18 patients of group 2 with 1-2 affected lung segments received rovamycin per os for 5-7 days three times a day (9,000,000 IU a day).