Publications by authors named "Semiramis Tootian"
Background: Amenorrhea is defined as the absence of menstruation at the reproductive age of women. Amenorrhea caused by various etiological factors including genetic factors, intrauterine malformations, endocrine dysfunction, and environmental factors. Genetic factors particularly chromosomal abnormalities are the main cause of Amenorrhea.
View Article and Find Full Text PDFBackground: Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs). The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously.
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- Chromosomal aberrations are significant contributors to multiple anomaly syndromes, making cytogenetic methods essential for diagnosis.
- A study analyzed chromosomal abnormalities in 3,728 patients over six years, revealing that 83.3% had normal karyotypes, while 16.7% exhibited abnormalities, predominantly autosomal patterns.
- The findings underscored the need for a local cytogenetic database in North East Iran to improve genetic counseling for affected families.
Reciprocal translocations represent one of the most common structural rearrangements observed in humans. Estimates of the population frequency range from 1/673 to 1/1000. We have described two novel balanced translocations in two unrelated families who experienced Recurrent spontaneous abortions (RSA) following their separate non-consanguineous marriages.
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