Publications by authors named "Semira Abdi Beshir"

Article Synopsis
  • Alzheimer's disease (AD) is characterized by the buildup of amyloid-beta proteins and tangles in the brain, and recent advancements in antiamyloid therapy aim to address this condition.
  • Lecanemab, a newly approved monoclonal antibody, has shown promise in slowing cognitive decline for early AD and mild cognitive impairment, yet it presents challenges including side effects and the need for additional tests.
  • Future research is needed to develop preventive strategies for AD and create more accessible and cost-effective treatments that target various aspects of the disease.
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Background: The Mediterranean diet has been linked to brain neuroprotection. Evidence from meta-analyses showed reduced risk of dementia with greater intake of vegetables and fruits, fish, and the Mediterranean diet. The current study raises important questions about the association between low risk dementia and Mediterranean diet.

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Background: Huntington's disease is an inherited progressive neurodegenerative disorder caused by an expansion of the polyglutamine tract leading to malformation and aggregation of the mutant huntingtin protein in the cell cytoplasm and nucleus of affected brain regions. The development of neuroprotective agents from plants has received considerable research attention.

Objective: Our study aims to investigate the neuroprotective effects of luteolin and the mechanisms that underline its potential mediated protection in the mutant htt neuroblastoma cells.

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Background: Recently, many drugs have been approved for halting overweight and obesity-few types of research shifted to using Anti-obesity medications (AOM) solely for well-being and shape-keeping.

Objective: This narrative review's objective was to explore the use of AOM in relation to their medical indications, efficacy, and cardiovascular safety.

Methods And Materials: We have conducted a narrative review of the literature on approved/non-approved AOM used for obesity and overweight.

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Background: Aducanumab, a new monoclonal antibody that targets -amyloid aggregates, has been granted conditional approval by the U.S. FDA for treatment of mild Alzheimer's disease (AD).

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Objectives: The main aim of this review was to summarize current evidence on approved and emerging non-statin lipid-lowering therapies.

Methods And Materials: Recent literature on U.S.

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Purpose: To assess the predicted rate and the factors associated with bleeding events among patients with non-valvular atrial fibrillation (NVAF) receiving dabigatran therapy.

Methods: This retrospective cohort study includes adult patients of two tertiary hospitals in Malaysia. Potential study subjects were identified using pharmacy supply database or novel oral anticoagulant (NOAC) registry.

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Background Oral anticoagulant therapy is indicated for the prevention of stroke or other thromboembolic events. Premature discontinuation of oral anticoagulants may increase the risk of thromboembolism resulting in adverse sequelae. There are sparse data on the prevalence and the predictors of dabigatran discontinuation in Malaysian patients with atrial fibrillation.

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