Publications by authors named "Semione G"

Objective: In recent years, the application of robotic assistance in diagnostic and therapeutic endovascular neurointerventional procedures has gained notable attention. In this systematic review and meta-analysis, we aim to evaluate the feasibility, safety, and current indications of robotic-assisted neurointerventions and to assess the degree of robotic assistance and reasons for unplanned manual conversion from robotic assistance.

Methods: We searched Medline, Scopus, Web of Science, and Cochrane Library databases following PRISMA guidelines and included studies with ≥ 4 patients reporting on robotic-assisted neurointerventions.

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Background: Arteriovenous Malformations (AVMs) pose a risk of neurologic deterioration, particularly when located in eloquent areas. While awake surgery is well-established for treating low-grade gliomas near eloquent areas, its efficacy for AVMs is less conclusively reported.

Methods: This study conducted a systematic review and individual patient data (IPD) meta-analysis following Cochrane Collaboration and PRISMA guidelines.

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Article Synopsis
  • Ependymomas are a type of brain tumor in children, making up 6-10% of such cases, and this study looks at the effectiveness of proton therapy for treatment.
  • A systematic review and meta-analysis were conducted, involving 908 patients from ten studies, focusing on survival rates and complications from the treatment.
  • The results indicate that while proton radiotherapy shows promising safety and efficacy with high overall survival rates, caution is advised due to variability in some adverse event outcomes indicated by wide confidence intervals.
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Background: Surgical clipping and endovascular coiling are well-established treatments for acutely ruptured intracranial aneurysms leading to acute subarachnoid hemorrhage (aSAH). However, these modalities have limitations, particularly in cases involving wide-necked, bifurcating, or dissecting aneurysms. Flow diverter (FD) devices, initially used for unruptured aneurysms, have emerged as an alternative treatment for ruptured aneurysms despite concerns about hemorrhagic complications.

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Background: The Contour Neurovascular System (CNS, Stryker, Kalamazoo, MI) has a unique design that allows it to address various aneurysm morphologies, including wide-necked, irregular, and shallow-shaped lesions. However, evidence of its safety and efficacy remains limited. This systematic review and meta-analysis synthesizes the current data on CNS performance.

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Objective: Several approaches can be used in the surgical treatment of vestibular schwannoma (VS), and the best approach remains uncertain in the literature. This systematic review and meta-analysis aim to compare the translabyrinthine approach (TLA) with the retrosigmoid approach (RSA) for VS in terms of postoperative complications.

Data Sources: PubMed, Web of Science, Embase, and Cochrane.

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  • Meta-analyses in medical science face challenges, particularly in neurosurgery, due to inconsistencies in defining and reporting complications, which limits their effectiveness.
  • A systematic review identified key limitations and created the NeuroComp Meta-Analysis Checklist to help standardize reporting and address common errors in such studies.
  • The checklist, comprising 23 items across 5 domains, aims to improve the reliability of future meta-analyses of neurosurgical complications, although it may not resolve all existing issues.
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Cerebral Proliferative Angiopathy (CPA) is a rare brain vascular malformation, similar to Arteriovenous Malformations (AVM) but lacking of early venous drainage. Presentation and treatment outcomes were investigated, examining for morbidity, mortality and complications. A meta-analysis was conducted according to PRISMA guidelines.

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Decompressive craniectomy is used to alleviate intracranial pressure in cases of traumatic brain injury and stroke by removing part of the skull to allow brain expansion. Traditionally, this procedure is followed by a watertight dural suture, although evidence supporting this method is not strong. This meta-analysis examines the feasibility of the open-dura (OD) approach versus the traditional closed-dura (CD) technique with watertight suturing.

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Objective: Unruptured middle cerebral artery aneurysm (uMCAA) has traditionally been treated with open surgical clipping (SC). Endovascular treatments (EVTs) were designed to reduce surgical risks in these cases. Nevertheless, despite its potential benefits, many surgeons favor SC for uMCAA.

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Article Synopsis
  • Small anterior communicating artery (ACoA) aneurysms are challenging for neurosurgeons due to their risky location and the potential for severe complications if they rupture; both surgical clipping and endovascular treatments are common approaches.
  • A meta-analysis was conducted across thirteen studies involving 637 patients to compare the efficacy and outcomes of surgical clipping versus endovascular treatment techniques, primarily focusing on coiling.
  • Results demonstrated similar overall outcomes for both methods, but surgical clipping had a significantly lower retreatment rate (0% vs. 18% for endovascular), while endovascular treatment had slightly higher mortality and complication rates, emphasizing the importance of factors such as surgeon expertise and patient characteristics in treatment decisions.
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  • Osteoporotic vertebral fractures lead to pain and diminished quality of life, and there’s ongoing debate on how best to manage them, particularly comparing percutaneous vertebroplasty (PV) to non-operative treatments (non-OT).* -
  • The analysis of randomized controlled trials showed PV provided significant pain relief at multiple time points, and notable improvements in quality of life were seen in the short term, but not consistently in the long term.* -
  • A substantial risk of cement leakage (42%) was noted with PV, but it did not increase the risk of new fractures; thus, careful patient selection is vital due to variability among studies.*
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Introduction: Conventionally, one branch of the superficial temporal artery (STA) is utilized to revascularize the middle cerebral artery (MCA). However, there is the possibility of utilizing both branches of the STA when performing the bypass, characterizing the double-barrel (DB) STA-MCA bypass. Notably, a lack of studies evaluating this technique led the authors to conduct a systematic review and single-arm meta-analysis.

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Background: Ventriculoatrial shunt (VAS) is an important treatment option for normal pressure hydrocephalus (NPH). However, clinical studies reporting the use of VAS for NPH lack sufficient standardization for meta-analytic comparisons that could provide robust evidence regarding its use. This study aims to assess the quality of reporting in these studies and develop a reporting guideline checklist to standardize terminology, concepts, and reporting while reinforcing the essential elements to ensure comparability and reproducibility.

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Background: Traditionally, patients undergoing craniotomy were subject to extended hospital stays for intensive monitoring and management of potential complications. However, with the evolution of surgical methods, anesthesia, and postoperative protocols, the feasibility and interest in same-day discharge (SDD) are growing. This study aimed to evaluate whether same-day discharge is a safe and feasible approach in craniotomy through a meta-analysis of the available literature.

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Brain Arteriovenous Malformations (bAVMs) are rare but high-risk developmental anomalies of the vascular system. Microsurgery through craniotomy is believed to be the mainstay standard treatment for many grades of bAVMs. However, a significant challenge emerges in the existing body of clinical studies on open surgery for bAVMs: the lack of reproducibility and comparability.

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Background: When traditional therapies are unsuitable, revascularization becomes essential for managing posterior inferior cerebellar artery (PICA) or vertebral artery aneurysms. Notably, the PICA-PICA bypass has emerged as a promising option, overshadowing the occipital artery-PICA (OA-PICA) bypass. The objective was to compare the safety and efficacy of OA-PICA and PICA-PICA bypasses.

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Background And Objectives: Ventriculoperitoneal shunt (VPS) is usually the primary choice for cerebrospinal fluid shunting for most neurosurgeons, while ventriculoatrial shunt (VAS) is a second-line procedure because of historical complications. Remarkably, there is no robust evidence claiming the superiority of VPS over VAS. Thus, we aimed to compare both procedures through a meta-analysis.

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A proof of concept is shown for the design of a high pressure heterogeneous catalysis reaction cell suitable for surface sensitive x-ray diffraction and x-ray reflectometry over planar samples using high energy synchrotron radiation in combination with mass spectrometry. This design enables measurements in a pressure range from several tens to hundreds of bars for surface investigations under realistic industrial conditions in heterogeneous catalysis or gaseous corrosion studies.

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From the catalytic, semiconducting, and optical properties of zinc oxide (ZnO) numerous potential applications emerge. For the physical and chemical properties of the surface, under-coordinated atoms often play an important role, necessitating systematic studies of their influence. Here we study the vicinal ZnO([Formula: see text]) surface, rich in under-coordinated sites, using a combination of several experimental techniques and density functional theory calculations.

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