Publications by authors named "Semine Ozdemir Dilek"

Objective: This study aimed to evaluate the impact of continuous glucose monitoring (CGM) assistance on glycemic control in children with type 1 diabetes (T1D) in earthquake-affected regions, comparing those who benefited from CGM with those who did not. Additionally, the study assessed changes in CGM metrics over nine months of CGM use.

Methods: A multicenter, cross-sectional study was conducted across 11 centers in Türkiye.

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Background: The COVID-19 pandemic caused a global public health problem with high morbidity and mortality rates. In this study, we aimed to evaluate the 25-hydroxyvitamin D (25(OH)D) status of patients presenting to the Pediatrics Department of Gaziantep Maternity and Children's Hospital in the 1-year period after the onset of the COVID-19 pandemic according to ethnicity, age, and gender.

Method: This cross-sectional study included the data of 7640 patients whose 25(OH)D levels were assessed at our hospital between March 2021 and March 2022.

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Article Synopsis
  • The study focuses on autosomal-recessive hypophosphataemic rickets type 2 (ARHR2), a rare disease linked to ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) deficiency, often seen in survivors of generalized arterial calcification of infancy (GACI).
  • Researchers analyzed clinical, biochemical, and genetic data from 18 patients across 9 medical centers, revealing common symptoms like limb deformities and short stature, with a mean age of diagnosis at around 4.2 years.
  • Findings suggest that ARHR2 typically appears later in life than GACI; understanding previous calcifications or related health issues can aid in diagnosing ARHR2 in patients treated for
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Objective: The aim of this study was to investigate the effects of the devastating 2023 Kahramanmaraş earthquake on the glycemic control of children with type 1 diabetes (T1DM) in Adana, Turkey. Additionally, the study aimed to assess the impact of continuous glucose monitoring (CGM) device assistance on glycemic control after the earthquake.

Materials And Methods: A retrospective study was conducted involving 134 children with T1DM receiving intensive insulin treatment.

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Introduction: There have been some significant changes regarding healthcare utilization during the COVID-19 pandemic. Majority of the reports about the impact of the COVID-19 pandemic on diabetes care are from the first wave of the pandemic. We aim to evaluate the potential effects of the COVID-19 pandemic on the severity of diabetic ketoacidosis (DKA) and new onset Type 1 diabetes presenting with DKA, and also evaluate children with DKA and acute COVID-19 infection.

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Purpose: This study aimed to investigate the utility of annual growth velocity (GV) standard deviation scores (SDSs) and compatibility and effectiveness of biochemical parameters in long-term treatment monitoring and management of 21-hydroxylase deficiency (21-OHD) in children.

Methods: Fifty children with 21-OHD were included in this study, and the biochemical parameters obtained during 402 visits were retrospectively evaluated. The follow-up period was divided between two GV SDS groups (GV SDS < 2 and GV SDS ≥ 2) and compared with auxological, biochemical, and clinical findings.

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Objectives: The COVID-19 pandemic is a global health problem with high morbidity and mortality. This study aimed to investigate patients who were diagnosed with type 1 diabetes during the pandemic and evaluate the effect of the pandemic on the clinical findings of these patients by comparing them with findings from a year prior.

Methods: Patients diagnosed with type 1 diabetes mellitus between 2019 and 2021 were separated into two groups: Patients diagnosed prepandemic and those diagnosed during the pandemic.

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Article Synopsis
  • Hereditary Hypophosphatemic Rickets (HHR) is a group of disorders with varying genetic causes, primarily characterized by low phosphate levels in the body, with the X-linked dominant form being the most common.
  • The study examined clinical and genetic features of 18 probands and 17 affected family members using next-generation sequencing to diagnose the condition effectively.
  • Researchers successfully diagnosed all 35 patients in their study, identifying nine new and ten known genetic variants, suggesting a two-tiered approach for diagnosis using targeted single gene analysis first, followed by comprehensive gene panel sequencing if needed.
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  • Idiopathic hypogonadotropic hypogonadism (IHH) leads to absent puberty and infertility due to a lack of gonadotropin-releasing hormone (GnRH), and can be associated with conditions like Kallmann syndrome.* -
  • Researchers identified ten rare variants in the genes SEMA3F and PLXNA3 among IHH patients, suggesting these genetic changes may disrupt signaling that is crucial for the development and function of GnRH and olfactory systems.* -
  • The study concluded that signaling from Semaphorin-3F through receptors PLXNA1-A3 is important for guiding GnRH neurons and olfactory nerve fibers, indicating that deficiencies in this signaling could be a factor in the development of I
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Objective: Mutations of the genes encoding transcription factors which play important roles in pituitary morphogenesis, differentiation and maturation may lead to combined pituitary hormone deficiency (CPHD). gene mutations are reported as the most frequent genetic aetiology of CHPD. The aim of this study was to describe the phenotypes of Turkish CPHD patients and define the frequency of mutations.

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