Synopsis of recent research by authors named "Semihcan Doken"
- Semihcan Doken's research primarily focuses on the evolutionary dynamics of tumor subclones in cancer, particularly in BRAF-driven cancers, elucidating the distinct trajectories of BRAF mutations in tumor evolution.
- In his 2019 study published in *Nature Communications*, Doken models the selection and propagation of BRAF mutation variants, revealing that strong BRAF mutations are associated with hard sweep dynamics while less activating mutations lead to softer sweeps or subclonality.
- Furthermore, Doken also investigates the application of deep learning in radiotherapy, working towards individualizing radiation doses based on tumor characteristics, as noted in his 2019 publication in *Lancet Digital Health*, which leverages CT imaging data to enhance treatment precision.
