[The efficacy of using low doses of immunomodulators for treating experimental tumors].

The data about the ability of various substances to cause definite reactions in biological objects are adduced, and, in particular, about the efficacy of a small doses of antitumoral chemopreparations in experiment. The results of investigation of the application efficacy of various doses of immunomodulating agents, such as arbisol, nucleoplat, the substrate from gram-negative bacteria Yersinia enterocolitica, antitumoral vaccine from the tumoral cells are presented for the cancer chemotherapy. While application of super-small doses of an antitumoral vaccine there was noted statistically significant inhibition of tumoral growth.

[The immunocorrection with Aerosil-350 of the natural resistance of mice found under conditions of an elevated radiation background].

Experiments on the CBA mice that had been within 30 km of the Chernobyl NPP accident for 3 months revealed a decrease in the phagocytic and bactericidal properties of peritoneal macrophages accompanied with a disturbance in the production of interleukin-1 and a tumor necrosis factor responsible for the cell immunity. A single administration of a silicon-containing enterosorbent Aerosil-350 expedient to remove radionuclides and ensure the organism detoxication made it possible to correct and restore the affected cell and organism immunity for 7 days.

[Antibodies to Bacillus megaterium H glycoprotein in patients with lung diseases].

Enzyme immunoassay performed in patients with malignant and benign affections of the lungs determined antibodies (Abs) to glycoprotein isolated from saprophyte microorganism Bacilus megaterium H. In pulmonary tuberculosis and nonspecific pulmonary inflammation the above Abs occurred in patients with fibrous-proliferative changes and associated neoplastic conditions. In lung cancer the Abs were detected in well and moderately differentiated tumors.

[Determination of antibodies to cross-reacting antigens of microorganisms in oncological diseases].

It was studied antibodies to saprophytic microorganism Bacillus megaterium H glycoprotein in healthy, oncological, non-oncological gastrointestinal patients and animals. High level of antibodies to microbial glycoprotein in blood sera was revealed in cancer and precancer patients. Analogical results were obtained in mice A/Sn and Balb/c with inductive or transplanted tumors.

[Change in the activity of tumor cell antigens as affected by treatment of the cells with the metabolic products of Bac. mesentericus AB-56].

Tumour cells (ascitic A/Sn mouse lymphosarcoma ON-2), treated by the Bac. mesentericus AB-56 metabolism products used for the production of antitumour autovaccines were analyzed for their antigenic properties. The reactions of precipitation in gel, zonal and oncoming immunoelectrophoresis, passive hemagglutination as well as cytotoxic, absorption and transplantation tests were used.