[Comparative analysis of a new modification of segmental tuberculin test with the routine Koch test].

A focal reaction plays the leading role in the assessment of segmental tests (ST). The sensitivity of ST is 72.4% and that of the Koch test is 64.

[Clinical picture of genital tuberculosis in different forms of its pathogen].

Improvement of bacteriological diagnosis is of great value for the clinical picture of genital tuberculosis. The purpose of the study is to reveal the clinical features of genital tuberculosis in L-forms of Mycobacterium tuberculosis (MBT) versus traditional bacteriological methods and polymerase chain reaction (PCR) test with MBT DNA. A hundred and fourteen patients with verified active genital tuberculosis were examined.

[Polymerase chain reaction and ligase chain reaction in the diagnosis of gynecological tuberculosis].

The polymerase chain reaction (PCR) and the ligase chain reaction (LCR) were evaluated and compared on 55 gynecological samples collected from women with active gynecological tuberculosis (Group 1), gynecological diseases other than tuberculosis (Group 2), and active tuberculosis elsewhere in the body without evidence for gynecological tuberculosis (Group 3). Acid fast staining and culture of Mycobacteria appeared to be ineffective in all specimens. The sensitivity of both amplification methods was 94.

[Features of surgery on female genital tuberculosis].

The paper gives the outcomes of treatment in 4983 patients treated at the Gynecology Clinic of the Saint Petersburg Research Institute of Phthisiopulmonology in 1977 to 1999. Surgical interventions different in their scope were made in 949 (19%) females. Analyzing 526 females of them indicated that organ-saving operations were performed in most cases (80.

[Features of hysterosalpingogram in verified genital tuberculosis].

Two hundred and fifty one women were examined. Of them, 93 patients with active tuberculosis made up Group 1, 38 with inactive tuberculosis Group 2, and 120 with nonspecific gynecological diseases Group 3. In All tuberculosis was verified by morphological and bacteriological studies.

[Laparoscopy in the complex diagnosis abdominal and genital tuberculosis].

Laparoscopy may detect pathognomonic signs of rashes on the visceral peritoneum, enlarged mesenteric lymph nodes, a profound commissural process in the small pelvis and Douglas space to identify abdominal and genital tuberculosis. The examinees were also found to have a prior tuberculosis of other sites or a contact with bacillary patients. Laparoscopy shows a 19.

[Clinico-morphological manifestations of genital tuberculosis in women].

Surgical material from 35 female patients with genital tuberculosis is analyzed. 57.1% of patients with clear-cut clinical symptoms showed tubercles and caseous foci.

[Diagnostic values of polymerase chain reaction test in females with genital tuberculosis].

The previously offered procedure for detecting. Mycobacterium tuberculosis, which is based on the polymerase chain reaction (PCR), has been tested for diagnosing genital tuberculosis in females. PCR was used to examine endometrial curettage specimens in 44 patients with different nosological entities, which showed a high sensitivity (80%) and a high specificity in the diagnosis of genital tuberculosis.

[Clinical aspects of genital tuberculosis in young women].

The review of 108 case histories of active genital tuberculosis (GT) in young women provided the following information: the symptoms emerged acutely in 30%, GT ran under the mask of nonspecific salpingo-oophoritis in 44%, GT was associated with pain, general toxicity, blood picture changes in 50, 30 and 66% of patients, respectively. In 70.7% of young women tuberculosis affected uterine tubes only, whereas in women over 30 years old the infection more frequently occurred in the uterus.

[The patient's age in different pathogenetic variants of choriocarcinoma in pregnancy and treatment results].

Patients with choriocarcinoma of normal pregnancy survived longer (mean age 36.3 +/- 1.2 years) than those suffering pathologic pregnancy choriocarcinoma (31.

[Mitotic regime of benign and malignant tumors of the trophoblast].

Mitotic regimen was studied in 52 choriocarcinomas and 45 hydatidiform moles. A clear-cut correlation between the rate of proliferation and degree of hyperplasia of the trophoblast was established for hydatidiform mole. Choriocarcinoma revealed higher values for mitotic index, incidence of pathologic mitoses and the profile of abnormal cell division patterns.

[Value of the morphological characteristics of choriocarcinoma in the prognosis of the disease].

Morphologic studies of 59 choriocarcinomas identified 56 histologic patterns which are of prognostic value. According to information index of Koulback, 17 of them were the most valuable (cytologic pattern of tumor, degree of polymorphism of cyto- and syncytiotrophoblast, mitotic activity of cytotrophoblast, type of tumor growth, degree of blood vessel invasion, etc.).

[Morphological characteristics of normal trophoblast and choriocarcinoma].

A certain ratio of cyto- and syntrophoblast cells in the chorion is known to exist during a certain third of pregnancy. It was shown that cell differentiation taking place in the placental epithelium can occur in the same order during malignant transformation of the trophoblast, too. The histological type of tumor was found to be in correlation with the pattern of pregnancy (normal or pathologic) preceding the disease as well as with the stage of pregnancy termination.

[Metastatic spread in various pathogenetic variants of choriocarcinoma].

The analysis of data on 208 cases of choriocarcinoma of different pathogenetic types established certain regularities of tumor dissemination into various organs. Metastases were observed in 33.3 +/- 5.

[Role of hydatidiform mole in the pathogenesis of choriocarcinoma].

Such pathogenetic patterns of choriocarcinoma (ChC) as development after normal and pathologic gestation are discussed. Clinically-based criteria of vesicular mole progression were established. It was found that 66.

[Immunological and hormono-metabolic indices in trophoblastic disease].

Certain immunologic and hormono-metabolic indexes were studied in patients with hydatidiform mole and uterine choriocarcinoma. Changes in T- and B-lymphocyte ratio were observed: B-lymphocyte levels were abnormally high in hydatidiform mole while those of T-lymphocytes-low in choriocarcinoma. Blastogenic response of lymphocytes in trophoblastic disease matched the mean values in healthy females.

[Risk factors and choice of treatment method with uterine choriocarcinoma patients].

An analysis of the results of uterine choriocarcinoma treatment versus the degree of risk is presented. Chemotherapy alone was found to be sufficient in 70.2% of cases free of risk, as compared with only 31.

[Clinical study of several aspects of the pathogenesis of choriocarcinoma during pregnancy].

It was shown that pathogenesis of choriocarcinoma depends on both the outcome of a preceding pregnancy and its nature (type). The latter, in turn, is determined whether pregnancy is normal (birth, abortion or miscarriage) or pathological (hydatidiform mole or ectopic choriocarcinoma). Different genetic and clinical patterns of pathogenesis of choriocarcinoma are identified--those of normal pregnancy and abnormal one.

[Risk factors in uterine choriocarcinoma patients and their effect on the treatment results].

Adverse factors of risk versus survival were studied in 208 cases of uterine choriocarcinoma. The said factors were not identified in some cases; in others, they ranged 1-4 and more in different combinations and were found to influence five-year results of treatment. In the absence of factors of risk, survival was 100.

[Immediate results of sarcolysine therapy of patients with malignant tumors of the ovaries].

The data on 41 patients with epithelial malignant tumors of the ovaries, who received sarcolysin at different stages of combined treatment, were analyzed. The following factors of therapeutic effect of sarcolysin were established: age of 41-50 years, presence of ascites, administration by two routes--intravenously and intracavitarily and a total dose in excess of 160 mg. Still another factor is contributed by the extent of surgical procedure carried out as primary treatment.

[Elimination of the pain syndrome in patients with generalized forms of malignant genital tumors].

The structure of chronic pain and its treatment in 41 cases of advanced malignant tumor of genitals are discussed. Pain syndrome was found to have a certain pattern (site, acuteness, depth, irradiation) which may be used as an additional diagnostic parameter. Different types of analgetic blockade (neurolysis) e.

[10 years' experience of the activities of the WHO International Cooperative Center for Clinical Study of Ovarian Tumors].

The data are reported on the many-year activities of the WHO Collaborating Centre on clinical study of ovarian cancer with regard to international cooperation of 10 countries. The organization, main trends and extent of the work performed are referred to, which made it possible to give an idea of the state of diagnosis and treatment of ovarian cancer in the world and enriched the experience of scientific cooperation in this field.