Membrane-Active Singlet Oxygen Photogenerators as a Paradigm for Broad-Spectrum Antivirals: The Case of Halogenated (BOron)-DIPYrromethenes.

Enveloped viruses, such as flaviviruses and coronaviruses, are pathogens of significant medical concern that cause severe infections in humans. Some photosensitizers are known to possess virucidal activity against enveloped viruses, targeting their lipid bilayer. Here we report a series of halogenated difluoroboron-dipyrromethene (BODIPYs) photosensitizers with strong virus-inactivating activity.

Genome Studies in L. and L. Based on Repeatomic and Cytogenetic Data.

L. and L. are valuable and promising food crops for multi-purpose use that are distributed worldwide in temperate, subtropical, and tropical zones.

Trehalose Interferes with the Photosynthetic Electron Transfer Chain of Permeating the Bacterial Chromatophore Membrane.

Disaccharide trehalose has been proven in many cases to be particularly effective in preserving the functional and structural integrity of biological macromolecules. In this work, we studied its effect on the electron transfer reactions that occur in the chromatophores of the photosynthetic bacterium . In the presence of a high concentration of trehalose, following the activation of the photochemistry by flashes of light, a slowdown of the electrogenic reactions related to the activity of the photosynthetic reaction center and cytochtome (cyt) complexes is observable.

[Giant pericranial sinus with extensive occipital calvarium defect].

Background: Giant non-traumatic and non-iatrogenic cranial vault defects are poorly studied due to their rarity. Therefore, diagnosis and analysis of their causes are difficult. In available literature, we found only 4 cases of giant pericranial sinus accompanied by extensive cranial vault defects.

Repeatome Analysis and Satellite DNA Chromosome Patterns in Species.

The cosmopolitan genus L. (Fabaceae) is divided into sections , , and This genus includes many valuable medicinal, melliferous, and forage species. The species taxonomy and genome relationships within the sections are still unclear.

Causality-aware Social Recommender System with Network Homophily Informed Multi-treatment Confounders.

Typical recommender systems utilize observed ratings of users as inputs to learn their preferences and aim to output recommendations of new items that users will like by predicting their potential ratings. The real world is driven by causality given that whether or not a user is made exposed to the item may significantly affect the rating. While some recent methods have taken a causal view to mitigate the confounding bias in observed rating data, few have recognized recommendation as a multiple causal inference problem that concerns numerous items simultaneously in practice.

Antioxidant properties of the soluble carotenoprotein AstaP and its feasibility for retinal protection against oxidative stress.

Photodamage to the outer segments of photoreceptor cells and their impaired utilization by retinal pigment epithelium (RPE) cells contribute to the development of age-related macular degeneration (AMD) leading to blindness. Degeneration of photoreceptor cells and RPE cells is triggered by reactive oxygen species (ROS) produced by photochemical reactions involving bisretinoids, by-products of the visual cycle, which accumulate in photoreceptor discs and lipofuscin granules of RPE. Carotenoids, natural antioxidants with high potential efficacy against a wide range of ROS, may protect against the cytotoxic properties of lipofuscin.

Kinetics of Electron Transfer between Redox Cofactors in Photosystem I Measured by High-Frequency EPR Spectroscopy.

The kinetics of the primary electron donor P and the quinone acceptor A redox transitions were simultaneously studied for the first time in the time range of 200 μs-10 ms using high-frequency pulse Q-band EPR spectroscopy at cryogenic temperatures in various complexes of photosystem I (PSI) from the cyanobacterium PCC 6803. In the A-core PSI complexes that lack 4Fe4S clusters, the kinetics of the A and P signals disappearance at 100 K were similar and had a characteristic time of τ ≈ 500 μs, caused by charge recombination in the PA ion-radical pair in the branch of redox cofactors. The kinetics of the backward electron transfer from A to P in the branch of redox cofactors with τ < 100 μs could not be resolved due to time limitations of the method.

Non-immunogenic recombinant staphylokinase versus alteplase for patients with massive pulmonary embolism: a randomized open-label, multicenter, parallel-group, non-inferiority trial, FORPE.

Background: Non-immunogenic staphylokinase is a modified recombinant staphylokinase with low immunogenicity, high thrombolytic activity, and fibrin selectivity.

Objectives: To assess the safety and efficacy of a single intravenous bolus of non-immunogenic staphylokinase compared with those of alteplase in patients with massive pulmonary embolism and hemodynamic instability.

Methods: A randomized, open-label, multicenter, parallel-group, non-inferiority trial, the FORPE (FORtelyzin Pulmionary Embolism), was conducted in Russia.

Palladium-Functionalized Polysiloxane Drop-Casted on Carbon Paper as a Heterogeneous Catalyst for the Suzuki-Miyaura Reaction.

In this work, a Pd(II)--cyclometalated complex was grafted to polysiloxanes via azide-alkyne cycloaddition. The obtained polymer-metal complex (Pd-PDMS) acts as a catalyst in the Suzuki-Miyaura reaction. Pd-PDMS was drop-casted onto a carbon fiber support, and the resulting membrane demonstrated catalytic activity in the cross-coupling reaction without yield loss after several catalytic cycles.

Laser Aggregometry Assessment of Blood Microrheology in a Slit Fluidic Channel Covered With Endothelial Cells.

The blood rheology in vitro in glass or plastic microfluidic chips is different from that in vivo in blood vessels with similar geometry. Absence of vascular endothelium is suggested to cause these discrepancies. This work aims to perform in vitro measurements of blood microrheologic parameters in a slit microfluidic channel covered with endothelial cells (HUVEC).

General Relations between Stress Fluctuations and Viscoelasticity in Amorphous Polymer and Glass-Forming Systems.

Mechanical stress governs the dynamics of viscoelastic polymer systems and supercooled glass-forming fluids. It was recently established that liquids with long terminal relaxation times are characterized by transiently frozen stress fields, which, moreover, exhibit long-range correlations contributing to the dynamically heterogeneous nature of such systems. Recent studies show that stress correlations and relaxation elastic moduli are intimately related in isotropic viscoelastic systems.

Ordering molecular diversity in untargeted metabolomics via molecular community networking.

Nature's molecular diversity is not random but displays intricate organization stemming from biological necessity. Molecular networking connects metabolites with structural similarity, enabling molecular discoveries from mass spectrometry data using arbitrary similarity thresholds that can fracture natural metabolite families. We present molecular community networking (MCN), that optimizes connectivity for each metabolite, rescuing lost relationships and capturing otherwise "hidden" metabolite connections.

Model of Accelerated Aging in CB6F2 Mice Induced by Ionizing Radiation.

A model for accelerated aging in mice was developed: CB6F2 mice aged 39-45 days were exposed to fractionated 4-fold relatively uniform γ-radiation (Cs, 0.98 Gy/min) at a total dose of 6.8 Gy.

Feasibility of a Fiber-Dispersive Raman Spectrometer for Biomarker Detection.

Raman spectroscopy is among the top analytical techniques for ultra-low-dense organic matter, crucial to the search for life and analysis of celestial body surfaces in space exploration missions. Achieving the ultimate sensitivity of in-situ Raman spectroscopy necessitates a breakthrough in detecting inelastically scattered light. Single-photon detectors (SPDs) operating in photon counting mode, which can differentiate between Raman and luminescence responses, are promising candidates for the challenging scientific requirements.

A randomized, open-label, phase 3 trial of pembrolizumab plus epacadostat versus sunitinib or pazopanib as first-line treatment for metastatic renal cell carcinoma (KEYNOTE-679/ECHO-302).

Background: Immunotherapy-based combinations have emerged as standard therapies for patients with metastatic renal cell carcinoma (mRCC). Pembrolizumab, a PD-1 inhibitor, combined with epacadostat, an indoleamine 2,3-deoxygenase 1 selective inhibitor, demonstrated promising antitumor activity in a phase 1 study in advanced solid tumors, including mRCC.

Methods: KEYNOTE-679/ECHO-302 was a randomized, open-label, parallel-group, multicenter, phase 3 study (NCT03260894) that compared pembrolizumab plus epacadostat with sunitinib or pazopanib as first-line treatment for mRCC.

Specificity of Photochemical Energy Conversion in Photosystem I from the Green Microalga .

Primary excitation energy transfer and charge separation in photosystem I (PSI) from the extremophile desert green alga grown in low light were studied using broadband femtosecond pump-probe spectroscopy in the spectral range from 400 to 850 nm and in the time range from 50 fs to 500 ps. Photochemical reactions were induced by the excitation into the blue and red edges of the chlorophyll Qy absorption band and compared with similar processes in PSI from the cyanobacterium  sp. PCC 6803.

Effects of a Hydrolyzed Lignin Derivative on Bleomycin-Induced Pulmonary Fibrosis in Mice.

Female C57BL/J mice with pulmonary fibrosis induced by injections of bleomycin (20 mg/kg intraperitoneally, 8 times for 4 weeks) were treated with a lignin derivative-based composition BP-C3 (80 mg/kg, daily intragastric administrations for 4 weeks). Bleomycin treatment increased the severity of pulmonary fibrosis (Ashcroft score increased from 1.43±0.

New Fire-Retardant Open-Cell Composite Polyurethane Foams Based on Triphenyl Phosphate and Natural Nanoscale Additives.

Despite the mechanical and physical properties of polyurethane foams (PUF), their application is still hindered by high inflammability. The elaboration of effective, low-cost, and environmentally friendly fire retardants remains a pressing issue that must be addressed. This work aims to show the feasibility of the successful application of natural nanomaterials, such as halloysite nanotubes and nanocellulose, as promising additives to the commercial halogen-free, fire-retardant triphenyl phosphate (TPP) to enhance the flame retardance of open-cell polyurethane foams.

Measurement of the Pion Form Factor with CMD-3 Detector and Its Implication to the Hadronic Contribution to Muon (g-2).

The cross section of the process e^{+}e^{-}→π^{+}π^{-} has been measured in the center-of-mass energy range from 0.32 to 1.2 GeV with the CMD-3 detector at the electron-positron collider VEPP-2000.

Dataset on investigating nucleation and growth kinetics of methane hydrate in aqueous methanol solutions.

This work systematically investigates the effect of methanol (MeOH) in a wide range of concentrations (0, 1, 2.5, 5, 10, 20, 30, 40, and 50 mass%) on methane hydrate nucleation and growth kinetics. Multiple measurements of gas hydrate onset temperatures and pressures for CH-HO and CH-MeOH-HO systems were performed by ramp cooling experiments (1 K/h) using sapphire rocking cell RCS6 apparatus.

[Metastatic risk factors in pheochromocytoma/paraganglioma].

Currently, all pheochromocytoma/paraganglioma (PPGLs) are considered malignant due to metastatic potential. Consequently, PPGLs are divided into «metastatic» and «non-metastatic». Metastatic PPGLs can be with synchronous metastasis (metastases appear simultaneously with the identified primary tumor) or metachronous (metastases develop after removal of the primary tumor).