Publications by authors named "Sema Yildirim Arslan"

Background: Cryptococcus neoformans causes cryptococcosis, primarily affecting immunocompromised individuals, including solid-organ transplant recipients, and, less frequently, immunocompetent people.

Case: A 15-year-old male with congenital hepatic fibrosis, portal hypertension, and cirrhosis underwent orthotopic liver transplantation. He received perioperative antimicrobial and antifungal prophylaxis and continued immunosuppressive treatment.

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  • Post-transplant lymphoproliferative disorder (PTLD) is a serious complication that can occur after solid organ transplants, particularly in pediatric liver transplant recipients.
  • A study conducted on 112 pediatric patients revealed that 43.75% developed Epstein-Barr virus (EBV) DNAemia, with 8 of these patients subsequently diagnosed with PTLD.
  • Findings showed that age at diagnosis of EBV DNAemia, as well as abnormal test results, were significantly higher in PTLD patients, indicating a correlation between older age and the development of this complication.
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  • Vaccines have significantly reduced COVID-19 hospitalizations among adolescents in Turkey, evidenced by a decline in hospitalizations during the vaccination period compared to pre-vaccination.
  • The study revealed that while there were more total hospitalizations during the vaccination period, the proportion of vaccinated adolescents requiring hospitalization was lower, reflecting the effectiveness of the vaccine.
  • Additionally, breakthrough infections in vaccinated adolescents were generally milder and less severe compared to infections in unvaccinated peers, with many being asymptomatic.
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Objectives: Familial Mediterranean fever is an autosomal recessive autoinflammatory inherited disease. We aimed to evaluate cardiac involvement in children with familial Mediterranean fever during the attack-free period.

Material And Methods: The prospective study included 75 familial Mediterranean fever patients during the attack-free period and 50 healthy children.

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  • The study focuses on the challenges of treating cerebrospinal fluid (CSF) shunt infections in children, particularly those caused by gram-negative bacteria and the rise of carbapenem-resistant (CR) strains.
  • It analyzed 64 infection episodes among 50 pediatric patients over a 10-year period, revealing that the majority were related to CSF shunt infections, with specific bacteria like Pseudomonas and E. coli being the most common culprits.
  • The research identified risk factors for CR infections, such as prior carbapenem use and extended hospital stays, and found a concerning 30-day mortality rate that was notably higher in the CR group compared to non-CR patients.
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Background: Bone and joint infections are common in children, particularly those under 10 years of age. While antimicrobial therapy can often successfully treat these infections, surgical drainage may also be necessary. It is important to note that prolonged courses of treatment have been associated with adverse events and drug reactions.

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Background: This study focused on timelines of infection episodes and dominant variants and aims to determine disease severity and outcome of pediatric patients with reinfection.

Materials And Methods: This study retrospectively evaluated the medical records of the hospitalized patients and/or outpatients aged 0-18 with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction between March 2020 and September 2022 at Ege University Children's Hospital.

Results: Ninety-one pediatric patients reinfected with SARS-CoV-2 were included in the study.

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The post-COVID-19 syndrome is a new syndrome defined in patients with a history of probable or confirmed SARS-CoV-2 infection, usually within three months of the onset of COVID-19, with symptoms and effects lasting at least 2 months. This study is aimed at comprehensively comparing symptoms of the post-COVID-19 syndrome in children with Delta and Omicron variants. This prospective study included children with COVID-19 followed in hospitalized or outpatient clinics in a tertiary hospital.

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  • The study investigates the rising cases of Stenotrophomonas maltophilia bloodstream infections (BSIs) in children, highlighting their high mortality rate compared to Pseudomonas aeruginosa BSIs.
  • The research, conducted between 2014 and 2021, identified significant risk factors such as previous Pediatric Intensive Care Unit admissions and prior use of specific antibiotics, which were more prevalent in S. maltophilia cases.
  • The findings suggest that prior carbapenem use is a key risk factor for developing S. maltophilia BSIs, while certain factors like PICU admission and glycopeptide use are linked to higher mortality rates, prompting the need for careful antibiotic treatment in at-risk patients.*
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  • - The study investigated the epidemiological trends of pediatric patients infected with SARS-CoV-2, finding that they generally display milder symptoms than adults but significantly contribute to virus transmission, especially during the delta variant period.
  • - Out of 3175 pediatric COVID-19 patients studied, 85.7% experienced at least one symptom, with a notable shift in age demographics as school-aged children and adolescents became more affected when the delta variant emerged.
  • - Overall, the research indicated a higher rate of pediatric cases relative to total COVID-19 cases during the delta variant period, and while hospitalization rates increased, the severity of cases requiring PICU admission remained consistent.
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The majority of children with coronavirus diseases 2019 (COVID-19) are asymptomatic or develop mild symptoms, and a small number of patients require hospitalization. Multisystem inflammatory syndrome in children (MIS-C) is one of the most severe clinical courses of COVID-19 and is suggested to be a hyperinflammatory condition. This study aimed to compare quantitative antibody levels against SARS-CoV-2 spike protein in children with COVID-19 and MIS-C.

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Background: We aimed to compare the acute kidney injury (AKI) incidence in pediatric septic shock patients according to the three different classifications.

Methods: We analyzed retrospectively 52 patients with severe sepsis between January 2019 and December 2019.

Results: While 21 patients have been diagnosed with SA-AKI according to the pRIFLE criteria, 20 children have been diagnosed according to the AKIN criteria, and 21 children have been diagnosed according to the KDIGO criteria.

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Multisystem Inflammatory Syndrome (MIS-C) is a new entity that emerges 2-4 weeks after the SARS-CoV-2 infection in children. MIS-C can affect all systems, the most severe of which is cardiac involvement. The duration of the cardiac symptoms is still uncertain and may be persistent or prolonged.

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Background: Studies on age-related differences in clinical and laboratory features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited. We aimed to evaluate the demographic, clinical, laboratory findings of SARS-CoV-2 infection in children younger than 6 months old and compare them with older children.

Methods: A single-center retrospective study, including 209 confirmed SARS-CoV-2 infection cases, was conducted between 11 March 2020 and 1 September 2021.

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Unlabelled: Multisystemic inflammatory syndrome (MIS-C) diagnosis remains difficult because the clinical features overlap with Kawasaki disease (KD). The study aims to highlight the clinical and laboratory features and outcomes of patients with MISC whose clinical manifestations overlap with or without KD. This study is a retrospective analysis of a case series designed for patients aged 1 month to 18 years in 28 hospitals between November 1, 2020, and June 9, 2021.

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Multisystem inflammatory syndrome in children (MIS-C) is a rare but life-threatening inflammatory immune response associated with severe acute respiratory syndrome coronavirus 2 infection. The majority of patients have been presented with hypotension, shock, gastrointestinal, cardiovascular and mucocutaneous symptoms. The incidence of neurologic symptoms in MIS-C is of rising concern as they are not well described and reported in fewer patients.

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A new inflammatory disease has emerged in children after the COVID-19 disease and has been named multisystem inflammatory syndrome in children (MIS-C). We report a case of cervical abscess in an infant with COVID-19 who was first considered to have MIS-C due to persistent fever, high inflammatory markers. A 10-month-old boy was admitted to the emergency department due to a 3-day fever and cervical lymphadenopathy.

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There have been a limited number of studies on coronavirus disease 2019 (COVID-19) in children. In this study, we aimed to investigate the demographic, clinical, and laboratory features of COVID-19 and to identify the role of mean platelet volume (MPV) in predicting the prognosis in children. A single-center retrospective study, including 251 confirmed and 65 suspected COVID-19 cases, was conducted between March 11, 2020, and December 11, 2020.

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