Protein aggregation correlates with many human diseases. Protein aggregates differ in structure and shape. Strategies to develop effective aggregation inhibitors that reach the clinic failed so far.
Alzheimer's disease is a leading cause of dementia, and recent research shows that immune cells outside the brain may play a role in the disease, but we don’t fully understand how yet.
In a study, scientists compared immune cell changes in Alzheimer's patients with mild cognitive issues to healthy people using advanced technology to see these cells better.
They discovered specific types of immune cells were linked to brain issues and memory problems, and some immunity changes were influenced by a gene called APOE ε4, showing it’s important to study these immune changes further.