Rhinofacial Conidiobolomycosis - A rare fungal infection of tropics.

Fungal sinusitis may be caused by filamentous fungi such as and and have immunocompromised states as specific risk factors, whereas may occur in apparently healthy persons having significant soil contact. This is, nonetheless, a rare condition with involvement of mucosa of the nose, para nasal sinuses and centrofacial soft tissues, bony or angioinvasion. It grows relentlessly, however, and may mimic soft tissue neoplasm causing facial disfigurement.

Effectiveness of Adjunctive High-Dose Infliximab Therapy to Improve Disability-Free Survival Among Patients With Severe Central Nervous System Tuberculosis: A Matched Retrospective Cohort Study.

Background: Few treatment options exist for patients with severe central nervous system (CNS) tuberculosis (TB) worsening due to inflammatory lesions, despite optimal antitubercular therapy (ATT) and steroids. Data regarding the efficacy and safety of infliximab in these patients are sparse.

Methods: We performed a matched retrospective cohort study based on Medical Research Council (MRC) grading system and modified Rankin Scale (mRS) scores comparing 2 groups of adults with CNS TB.