Synthesis of β-enamino malonates through caesium carbonate-promoted reaction of nitro-substituted donor-acceptor cyclopropanes.

A caesium carbonate-promoted reaction of nitro-substituted donor-acceptor cyclopropanes (DACs) with primary aromatic amines in water provides a convenient access to β-enamino malonates under mild reaction conditions. The transformation takes place through the formation of allene intermediates from the DACs followed by the conjugate addition of various primary aromatic amines to the intermediates. The reaction proceeds more efficiently in water as compared with organic solvents and the products were isolated in good yields by filtering through a silica gel column without any prior extraction procedure.

Fabrication of MnSnO intercalated TA-rGO modified sensor for selective electrochemical detection of chloramphenicol in real samples.

Chloramphenicol (CAP), a potent antibiotic capable of inhibiting protein synthesis, presents significant challenges related to long-term dosing and its persistent leaching into the environment, raising concerns about environmental contamination and resistance development. To address this issue, we developed a reliable, low-cost, and biocompatible nanocomposite material comprising tannic acid (TA)-reduced graphene oxide (rGO) intercalated into manganese-doped tin oxide nanoparticles (MnSnO₂ NPs). The structural formation and catalytic activity of the MnSnO₂ NPs/TA-rGO nanocomposite were characterized using field emission-scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and electrochemical techniques.

The Study to Assess the Effectiveness of Cissus Quadrangularis among Postmenopausal Women with Osteopenia.

Background: Osteopenia refers to bone density that is not only normal but also not as low as that noted in osteoporosis. Osteopenia leads to osteoporosis and increases the risk of fractures. Current research is focused on agents that will prevent or slow the progression of bone loss.

Characterising the Metabolomic Diversity and Biological Potentials of Extracts from Different Parts of Two Species Using UHPLC-MS/MS and In Vitro Techniques.

This study investigates the biochemical composition and biological properties of different parts (leaves, roots, and twigs) of two species ( and ). The extracts were analysed using UHPLC-MS/MS to determine their chemical profiling. A range of antioxidant assays were performed to evaluate the extract's antioxidant capabilities.

Plasma miR-122-5p and miR-142-5p and their role in chemoresistance of colon cancer patients.

Chemoresistance represents a major issue affecting cancer therapy efficacy. Because microRNAs (miRNAs) regulate gene expression on multiple levels, their role in chemoresistance development is reasonably certain. In our previous study, miR-122-5p and miR-142-5p were identified as diagnostic, prognostic, and predictive biomarkers for primary and metastatic rectal cancer.

Computational Evaluation on the Interactions of an Opaque-Phase ABC Transporter Associated with Fluconazole Resistance in , by the Bio-Active Compounds.

Objectives: is an opportunistic pathogen that occurs as harmless commensals in the intestine, urogenital tract, and skin. It has been influenced by a variety of host conditions and has now evolved as a resistant strain. The aim of this study was thus detect the fluconazole resistant from the root caries specimens and to computationally evaluate the interactions of an opaque-phase ABC transporter protein with the bio-active compounds.

Carrageenan derived polyelectrolyte complexes material: An effective bifunctional for electrochemical sensing of sulfamethazine and antibacterial activity.

Biopolymer-derived polyelectrolyte complexes (PECs) are a class of materials that have emerged as promising candidates for developing advanced electrochemical sensors due to their tunable properties, biocompatibility, cost-effective production, and high surface area. PECs are formed by combining positively and negatively charged polymers, resulting in a network with intriguing properties that can be tailored for specific sensing applications. The resultant PECs-based nanocomposites were used to modify the glassy carbon electrode (GCE) to detect the sulfamethazine (SFZ) antibiotic drug.

Interactions of drosophila cryptochrome.

In this study, we investigate the intricate regulatory mechanisms underlying the circadian clock in Drosophila, focusing on the light-induced conformational changes in the cryptochrome (DmCry). Upon light exposure, DmCry undergoes conformational changes that prompt its binding to Timeless and Jetlag proteins, initiating a cascade crucial for the starting of a new circadian cycle. DmCry is subsequently degraded, contributing to the desensitization of the resetting mechanism.

Chemical exploration of different extracts from leaves and their potential utilization for global health problems: and network pharmacology validation.

L. is of great interest as a traditional additive in various folk remedies in several countries, including Turkey. We aimed to determine the chemical profile (assisted by high-Performance liquid chromatography-electrospray ionization-tandem mass apectrometry (HPLC-ESI-MS/MS) experiments of three extracts obtained by different polarity solvents viz.

Effectively Reinforced α-BiO MPs/PDA-RGO Sensor for Selective Modality Sensing of a Hazardous Phenolic Compound.

The phenolic compound trichlorophenol (TCP) is an ingredient in fungicides and herbicides. This compound's high stability, bioaccumulation, toxicity, and poor biodegradability result in severe environmental and biological health issues. Consequently, it is crucial to have an affordable and sensitive method for detecting TCP in environmental samples.

Apoptosis-inducing, anti-angiogenic and anti-migratory effects of a dinuclear Pd(II) complex on breast cancer: A promising novel compound.

Because of the high mortality and morbidity rate of breast cancer, successful management of the disease requires synthesis of novel compounds. To this end, ongoing attempts to create new candidates include synthesis of multinuclear metal complexes. The high DNA binding affinity and cytotoxic activity of these complexes makes them promising as breast cancer treatments.

LC-MS/MS and GC-MS profiling, antioxidant, enzyme inhibition, and antiproliferative activities of Thymus leucostomus H ausskn. & V elen. extracts.

The chemical composition as well as antioxidant, antiproliferative, and enzyme inhibition activities of extracts from aerial parts of Thymus leucostomus H ausskn. & V elen. obtained with hexane, methanol, and water were evaluated.

Molecular docking analysis of long-chain alkanes with the β-lactamase BEL-1 from .

Pseudomonas aeruginosa is a gram-negative opportunistic bacterium that is a concern worldwide due to its innate antibiotic resistance properties. This warrants the development of non-antibiotic compounds that can potentially address the growing concern. Therefore, it is of interest to document the molecular docking analysis data of three long-chain alkanes, namely, eicosane, triacontane, and nonadecane with β-lactamase BEL-1.

Bio-mineralized tin/bismuth oxide nanoparticles with silk fibroins for efficient electrochemical detection of 2-nitroaniline in river water samples.

In recent years, the usage of nitroaniline has played a vital role in pharmaceutical formulations as it is a crucial ingredient in the synthesis of pesticides and dyes. However, the level of nitroaniline existing in industrial waste keeps rising the environmental contamination. Thus, monitoring of active nitro-residuals becomes more significant in reducing the toxicity of the ecosystem.

Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice.

Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease with apoptosis. Here, we discovered a molecule (M47) that destabilizes Cryptochrome 1 (CRY1) both in vitro and in vivo.

Proteome analysis of the circadian clock protein PERIOD2.

Circadian rhythms are a series of endogenous autonomous 24-h oscillations generated by the circadian clock. At the molecular level, the circadian clock is based on a transcription-translation feedback loop, in which BMAL1 and CLOCK transcription factors of the positive arm activate the expression of CRYPTOCHROME (CRY) and PERIOD (PER) genes of the negative arm as well as the circadian clock-regulated genes. There are three PER proteins, of which PER2 shows the strongest oscillation at both stability and cellular localization level.

Standardization of Sibt. & Sm. and M. Bieb. Extracts with Carbohydrate Digestive Enzyme Inhibitory and Antioxidant Activities.

species growing in Turkey are used for various medicinal purposes in traditional folk medicine. We aimed to evaluate antidiabetic (α-glucosidase and α-amylase inhibition assays), antiobesity (pancreatic lipase inhibition assay), and antioxidant (ABTS and DPPH radical scavenging activities, ferric reducing activity, metal chelating activity, and phosphomolybdenum assay) activities of the extracts obtained from branches, leaves, and fruits of and . The branch (IC = 67.

Modification of sesame ( L.) for Triacylglycerol accumulation in plant biomass for biofuel applications.

Sesame is considered as the queen of oil seeds owing to its high oil content of about 56-62% and good quality oil. Sesame oil alone or in combination with other vegetable oils can yield good quality biodiesel. Sesame biodiesel blends up to 20% yields fuel efficiency and power output on par with mineral diesel but superior in environmental performance.

Correlating the trends of COVID-19 spread and air quality during lockdowns in Tier-I and Tier-II cities of India-lessons learnt and futuristic strategies.

The present study focuses on the impact of early imposed lockdowns and following unlocking phases on the status of air quality in six Tier-I and nine Tier-II cities of India as compared to the pre-lockdown measures. Furthermore, the study highlights the possible correlation of air quality index (AQI) with the initial trend of COVID-19 issues including the vaccination cases. Based on the statistical data analysis, we observed that the long-term averages for representing the short-term pre-lockdown conditions can impose a healing effect to the observed anomalies in air pollution data.

Glutathione and cystamine functionalized MoScore-shell nanoparticles for enhanced electrochemical detection of doxorubicin.

Two-dimensional (2D) MoScore-shell nanoparticles were synthesized using an eco-friendly surface functionalization-agent with L-glutathione and cystamine (L-GSH-MoS-CYS) using ultrasonic frequency of 20-25 kHz. The novel modified electrode was evaluated for the electrochemical detection of doxorubicin (DOX), through cyclic and differential pulse voltammetric techniques. The electro-catalytic oxidation currents of DOX exhibited a linear relationship in the concentration ranges 0.

Transcriptome analysis of the circadian clock gene BMAL1 deletion with opposite carcinogenic effects.

We have previously reported that the deletion of BMAL1 gene has opposite effects in respect to its contribution to the pathways that are effective in the multistage carcinogenesis process. BMAL1 deletion sensitized nearly normal breast epithelial (MCF10A) and invasive breast cancer cells (MDA-MB-231) to cisplatin- and doxorubicin-induced apoptosis, while this deletion also aggravated the invasive potential of MDA-MB-231 cells. However, the mechanistic relationship of the seemingly opposite contribution of BMAL1 deletion to carcinogenesis process is not known at genome-wide level.