Synthesis, crystal structure and Hirshfeld surface analysis of sodium bis-(malonato)borate monohydrate.

In the title salt, poly[aqua-[μ-bis-(malonato)borato]sodium], {[Na(CHBO)]·HO} or Na·[B(CHO)]·HO, the sodium cation exhibits fivefold coordination by four carbonyl O atoms of the bis-(malonato)borate anions and a water O atom. The tetra-hedral B atom at the centre of the anion leads to the formation of a polymeric three-dimensional framework, which is consolidated by C-H⋯O and O-H⋯O hydrogen bonds. A Hirshfeld surface analysis indicates that the most significant contacts in the crystal packing are H⋯O/O⋯H (49.

Identification of the Transcription Factor Relationships Associated with Androgen Deprivation Therapy Response and Metastatic Progression in Prostate Cancer.

Background: Patients with locally advanced or recurrent prostate cancer typically undergo androgen deprivation therapy (ADT), but the benefits are often short-lived and the responses variable. ADT failure results in castration-resistant prostate cancer (CRPC), which inevitably leads to metastasis. We hypothesized that differences in tumor transcriptional programs may reflect differential responses to ADT and subsequent metastasis.