Therapeutic Potential of FTO Demethylase in Metabolism and Disease Pathways.

The crucial involvement of the Fat Mass and Obesity-associated (FTO) protein in both metabolic and non-metabolic diseases has been documented since its discovery. This enzyme, known as FTO, is a demethylase that belongs to the 2-oxoglutarate-dependent nucleic acid demethylases. Its primary function is to target N6-methyladenosine (mA) in RNA, which is crucial in regulating RNA stability, processing, and expression.