Anti-inflammatory efficacy of petasin-incorporated zinc oxide eugenol sealer - An zebrafish study.

Background: The eugenol from zinc oxide eugenol (ZnOE) sealer tends to diffuse to the periapical region resulting in inflammation. Several modifications of ZnOE sealer have been formulated to minimize the inflammatory potential of the ZnOE sealer. contains petasin which possesses anti-inflammatory property used in treatment of migraine and allergic rhinitis.

A novel petasin-modified zinc oxide eugenol sealer.

Objective: Zinc oxide eugenol (ZOE) is one of the most commonly used root canal sealer. However, it has few drawbacks such as cytotoxicity, solubility, and irritation to periapical tissues. The scope of this study was to investigate the setting time, solubility, cytotoxic effects, and anti-inflammatory action of ZOE sealer with the modification of its liquid component by the addition of petasin extract in the ratios 1:1, 5:1, and 10:1.