A DNA and Self-Doped Conjugated Polyelectrolyte Assembled for Organic Optoelectronics and Bioelectronics.

Deoxyribonucleic acid (DNA) and a self-doped conjugated polyelectrolyte, poly(4-(2,3-dihydrothieno[3,4-b]-[1,4]dioxin-2-yl-methoxy)-1-butanesulfonic acid (PEDOT-S), are assembled for organic optoelectronics and bioelectronics. The DNA's helix-coil phase transition in water is studied as a function of composition by thermo-optical analysis. DNA and PEDOT-S are functionalized by using a surfactant, cetyltrimethylammonium chloride (CTMA), and DNA:CTMA, PEDOT-S:CTMA, and DNA:CTMA:PEDOT-S:CTMA complexes were characterized regarding thermal, optical, morphological, and structural properties.

Self-assembled Cu(II) and Ni(II) metallamacrocycles formed from 3,3,3',3'-tetrabenzyl-1,1'-aroylbis(thiourea) ligands: DNA and protein binding studies, and cytotoxicity of trinuclear complexes.

Self-assembled metallamacrocyclic Cu(II) and Ni(II) complexes of the types [Cu(L1-O,S)]3 (1), [Ni(L1-O,S)]3 (2), [Cu(L2-O,S)]2 (3) and [Ni(L2-O,S)]2 (4) [H2L1 = 3,3,3',3'-tetrabenzyl-1,1'-terephthaloylbis(thiourea) and H2L2 = 3,3,3',3'-tetrabenzyl-1,1'-isophthaloylbis(thiourea)] were synthesized and characterized by analytical, spectroscopic (UV-Vis, FT-IR, mass, (1)H & (13)C NMR and EPR) and single crystal X-ray diffraction techniques. The crystal structures of [Ni(L1-O,S)]3 and [Cu(L2-O,S)(Py)]2 showed the formation of self-assembled 3:3 and 2:2 metallamacrocyclic Cu(II) and Ni(II) complexes respectively. The binding affinity and binding mode of the trinuclear complexes toward CT DNA were determined by UV-Vis spectrophotometric titrations and the fluorescent indicator displacement (FID) assay.