Publications by authors named "Selma Kose"
Article Synopsis
- Extracellular aggregation of amyloid-beta (Aβ) in the brain is linked to Alzheimer's disease (AD), and its intraneuronal accumulation may also contribute to disease progression.
- The study investigates the effect of tripeptidyl peptidase-1 (TPP1), a lysosomal enzyme, and its recombinant form (cerliponase alfa) in reducing Aβ levels within neuron cells while examining the role of autophagy.
- Results showed that cerliponase alfa decreased Aβ accumulation and triggered autophagy-related pathways, suggesting TPP1 enhancement might be a potential Alzheimer’s therapy.
