Outcomes of a Peer Mentor Intervention for Persons With Recurrent Psychiatric Hospitalization.

Objective: This article presents findings from a randomized controlled trial of a peer support mentorship intervention designed for individuals with serious mental illness and frequent, recurrent psychiatric hospitalizations.

Methods: Seventy-six individuals who were diagnosed as having a major psychotic or mood disorder and who had at least two psychiatric hospitalizations or more than three emergency department visits within the 18 months prior to the index hospitalization participated in this trial. Participants were randomly assigned to one of two conditions: standard care or a peer mentor plus standard care.

Direct measurement of dysprosium(III)···dysprosium(III) interactions in a single-molecule magnet.

Lanthanide compounds show much higher energy barriers to magnetic relaxation than 3d-block compounds, and this has led to speculation that they could be used in molecular spintronic devices. Prototype molecular spin valves and molecular transistors have been reported, with remarkable experiments showing the influence of nuclear hyperfine coupling on transport properties. Modelling magnetic data measured on lanthanides is always complicated due to the strong spin-orbit coupling and subtle crystal field effects observed for the 4f-ions; this problem becomes still more challenging when interactions between lanthanide ions are also important.

Synthesis, structure, and paramagnetism of manganese(II) iminophosphate complexes.

The coordination chemistry of the bidentate bis(imino)bis(amino)phosphate ligands [Me(3)SiN═P{NR}{N(H)R}(2)](-), where R = n-propyl is [L(1)H(2)](-), R = cyclohexyl is [L(2)H(2)](-), and R = tert-butyl is [L(3)H(2)](-), with manganese(II), is described. The bis(imino)bis(amino)phosphate-manganese(II) complexes [(η(5)-Cp)Mn(μ-L(1)H(2))](2) (1), [Mn(L(2)H(2))(2)]·THF (2·THF), and [(η(5)-Cp)Mn(L(3)H(2))] (3) were synthesized by monodeprotonation of the respective pro-ligands by manganocene, Cp(2)Mn. The molecular structures of 1-3 reveal that the steric demands of the ligand N-substituents play a dominant role in determining the aggregation state and overall composition of the manganese(II) complexes.

Oscillatory template exchange in polyoxometalate capsules: a ligand-triggered, redox-powered, chemically damped oscillation.

The redox-controlled driven oscillatory template exchange between phosphate (P) and vanadate (V) anions enclosed in an {X(2)M(18)} cluster is reported. Extensive investigations using a range of techniques, including correlated ESI-MS, EPR, and UV-vis as a function of reaction time, showed that six complete oscillations interconverting the capsule species present in solution from {P(2)M(18)} to {V(2)M(18)} were possible, provided that a sufficient concentration of the TEA reducing agent was present in solution.

An in situ electrochemical cell for Q- and W-band EPR spectroscopy.

A simple design for an in situ, three-electrode spectroelectrochemical cell is reported that can be used in commercial Q- and W-band (ca. 34 and 94 GHz, respectively) electron paramagnetic resonance (EPR) spectrometers, using standard sample tubing (1.0 and 0.

Synthesis and structure of cationic guanidinate-bridged bimetallic {Li7M} cubes (M = Mn, Co, Zn) with inverse crown counter anions.

The reactions of the heteroleptic lithium amide [Li(3)(μ-hmds)(2)(μ,μ-hpp)] (1), where [hmds](-) = hexamethyldisilazide and [hpp](-) = hexahydropyrimidopyrimidide, with MnCl(2), CoCl(2) or ZnBr(2) result in the formation of the separated ion-pairs [MLi(7)(μ(8)-O)(μ,μ-hpp)(6)](+)[A](-), which each consist of a {MLi(7)} oxo-centred cube structural motif (M = Mn 2, Co 4, Zn 5), with each face of the cube being bridged by an [hpp](-) ligand. In the case of M = Mn and Co, the counter ion, [A](-), is the pentagonal anionic inverse crown [{Li(μ-hmds)}(5)(μ(5)-Cl)](-) (3), whereas the reaction with M = Zn produces the known tris-amido zincate [Zn(hmds)(3)](-) counter anion.

Effectiveness of peer support in reducing readmissions of persons with multiple psychiatric hospitalizations.

Objective: The study examined the feasibility and effectiveness of using peer support to reduce recurrent psychiatric hospitalizations.

Methods: A randomized controlled design was used, with follow-up at nine months after an index discharge from an academically affiliated psychiatric hospital. Patients were 18 years or older with major mental illness and had been hospitalized three or more times in the prior 18 months.

Qualitative study of high-cost patients in an urban primary care centre.

Objectives: We examined patient accounts of illness and care among primary care patients whose medical services costs were high in order to illuminate factors associated with high cost.

Methods: Thirty-three primary care patients with multiple chronic illnesses in an urban clinic serving a resource poor neighbourhood were selected from a range of high medical cost patients. Participants were interviewed with open-ended questions to investigate experiences of illnesses and care; their responses were examined for prominent themes using qualitative analysis methodology.

Thyroid follicular lesions induced by oral treatment for 2 years with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds in female Harlan Sprague-Dawley rats.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and structurally-similar dioxin-like compounds affect thyroid function and morphology and thyroid hormone metabolism in animals and humans. The National Toxicology Program conducted eight 2-year gavage studies in female Harlan Sprague-Dawley rats to determine the relative potency of chronic toxicity and carcinogenicity of TCDD, 3,3',4,4',5-pentachlorobiphenyl (PCB126), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), 2,3',4,4',5-pentachlorobiphenyl (PCB118), 2,2',4,4',5,5'-hexachloro-biphenyl (PCB153), a tertiary mixture of TCDD/PCB126/PeCDF, and two binary mixtures (PCB126/PCB153 and PCB126/PCB118). Administration of these compounds was associated with increased incidences of thyroid follicular cell hypertrophy, variably observed in the 14-, 31-, and 53-week interim and 2-year sacrifice groups.

Enabling or Engaging? The Role of Recovery Support Services in Addiction Recovery.

Recovery capital-the quantity and quality of internal and external resources to initiate and maintain recovery-is explored with suggestions for how recovery support services (RSS) (nontraditional, and often nonprofessional support) can be utilized within a context of comprehensive addiction services. This article includes a brief history of RSS, conceptual and operational definitions of RSS, a framework for evaluating RSS, along with a review of recent empirical evidence that suggests that rather than enabling continued addiction, recovery supports are effective at engaging people into care, especially those who have little recovery capital, and/or who otherwise would likely have little to no "access to recovery."

Reproductive lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin and dioxin-like compounds.

Results from previously published animal studies suggest that prenatal and postnatal exposure to dioxin and dioxin-like compounds (DLCs) may profoundly affect the reproductive system of both sexes via endocrine disruption. In the present work, we evaluate the toxicity and carcinogenicity of various DLCs, with an emphasis on their effect on the reproductive organs, induced by chronic exposure of female adult Harlan Sprague-Dawley rats. This investigation represents part of an initiative of the National Toxicology Program to determine the relative potency of chronic toxicity and carcinogenicity of polychlorinated dioxins, furans, and biphenyls.

Becoming expert and understanding mental illness.

In the process of becoming an expert in the mental health field the newcomer, through reading, lectures, and supervision, is taught what to notice and how to structure and conceptualize that information. A less recognized part of this learning process is that the newcomer is also taught, explicitly or implicitly, what not to notice, what not to pay attention to. Much of the subjectivity of the newcomer and of the patients and clients he or she sees is pushed, purposely or not, out of the way and is then lost to view.

Cascading crises, resilience and social support within the onset and development of multiple chronic conditions.

Objective: To describe and better understand adults' responses to the onset, accrual and influence of multiple chronic conditions and to social support in adapting to consequent difficulties.

Methods: Qualitative study of 33 adults with multiple chronic illnesses randomly sampled from an urban primary care clinic. Semi-structured interviews targeted retrospective accounts of illness onset, consequent loss, as well as current accounts of social support and adaptation.

Self-efficacy and self-care: missing ingredients in health and healthcare among adults with serious mental illnesses.

To help inform the design of a self-management intervention for improving the physical health of adults with serious mental illnesses, we conducted focus groups about their perceived medical care and physical health needs. Adults with serious mental illnesses participated in four semi-structured focus groups conducted at a transitional living facility, a social club, and a Hispanic outpatient mental health clinic. Questions included their recent experiences of seeking medical care, the effect of having a mental illnesses diagnosis, strategies for active self-care, and perceived barriers to better physical health.

Beyond generic support: incidence and impact of invalidation in peer services for clients with severe mental illness.

Objective: This study explored experiences of validation and invalidation among clients with severe mental illness in treatment with either peer providers or traditional providers. Associations between six- and 12-month outcomes and validating and invalidating provider communications were also examined.

Methods: A total of 137 adults with severe mental illness were randomly assigned to either peer-based or traditional intensive case management.

Pulmonary lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin-like compounds.

Dioxin and dioxin-related compounds have been associated with high incidences of pulmonary dysfunctions and/or cancers in humans. To evaluate the relative potencies of effects of these compounds, the National Toxicology Program completed a series of two-year bioassays which were conducted using female Harlan Sprague-Dawley rats. The rats were treated orally for up to 2 years with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3,3',4,4',5-pentachlorobiphenyl (PCB126), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and a ternary mixture of TCDD, PCB126 and PeCDF.

A peer-support, group intervention to reduce substance use and criminality among persons with severe mental illness.

Objective: This study compared the effectiveness of two interventions in reducing alcohol use, drug use, and criminal justice charges for persons with severe mental illnesses: first, a community-oriented group intervention with citizenship training and peer support that was combined with standard clinical treatment, including jail diversion services, and second, standard clinical treatment with jail diversion services alone.

Methods: A total of 114 adults with serious mental illness participated in a 2 x 3 prospective longitudinal, randomized clinical trial with two levels of intervention (group and peer support for the experimental condition and standard services for the control) and three interviews (baseline, six months, and 12 months). Self-report questionnaires assessed alcohol and drug use, and program databases assessed criminal justice contacts.

Sober housing and motivational interviewing: the Treatment Access Project.

This paper describes an innovative program that provides rental subsidies for sober housing and supportive services to persons in early recovery who are homeless and have substance use disorders. Preliminary data point to the success of this program in enhancing recovery and exiting from homelessness. In supporting sober house placements, the Treatment Access Project creates a bridge that supports these individuals in their transition from clinical treatment services to the community.

Respiratory tract lesions in noninhalation studies.

This paper reviews respiratory tract lesions observed in rodents administered various chemicals by noninhalation routes. Chemicals administered by inhalation caused lesions in the respiratory tract and were well described; however, when chemicals were administered by noninhalation routes the effort to evaluate tissues for lesions may have been less or not considered, especially in the upper respiratory tract, and some lesions may have gone undetected. Lesions described in this review mostly occurred in rodent chronic noninhalation studies conducted by the National Toxicology Program; however, some were noted in studies of shorter duration.

The treatment relationship in peer-based and regular case management for clients with severe mental illness.

Objective: This study compared the quality of treatment relationships and engagement in peer-based and regular case management. It also assessed the value of positive relationship qualities in predicting motivation for and use of community-based services for persons with severe mental illness.

Methods: One hundred thirty-seven adults with severe mental illness participated in a 2x2 prospective longitudinal randomized clinical trial with two levels of case management intervention (peer and regular) and two interviews (six and 12 months).

Play, pleasure, and other positive life events: "non-specific" factors in recovery from mental illness?

As part of the emerging recovery paradigm, there is an increasing need for psychiatric treatment and rehabilitation to be strengths-based and to be driven by the desires and preferences of the person with mental illness. Yet if mental illness is a brain disease, it is not at all clear how these characteristics contribute to improvement in the person's condition or influence the course and outcome of the disorder. To avoid these aspects being relegated to the role of nonspecific factors, the field must develop an understanding of the role of strengths and interests in recovery.

Peer support among adults with serious mental illness: a report from the field.

Peer support is based on the belief that people who have faced, endured, and overcome adversity can offer useful support, encouragement, hope, and perhaps mentorship to others facing similar situations. While this belief is well accepted for many conditions, such as addiction, trauma, or cancer, stigma and stereotypes about mental illness have impeded attempts on the part of people in recovery to offer such supports within the mental health system. Beginning in the early 1990s with programs that deployed people with mental illness to provide conventional services such as case management, opportunities for the provision and receipt of peer support within the mental health system have proliferated rapidly across the country as part of the emerging recovery movement.

Incidences of selected lesions in control female Harlan Sprague-Dawley rats from two-year studies performed by the National Toxicology Program.

The NTP has a long history of using Fischer rats and has compiled a large database of incidences of lesions seen in control animals. Such a database is lacking for Harlan Sprague-Dawley (SD) rats. The intention of this paper is to report spontaneous lesions observed in female vehicle control Harlan SD rats, and to compare the incidence in 2 strains of rats (Fischer and Harlan SD) used in NTP studies.