Publications by authors named "Sella Takei"
Article Synopsis
- A microdialysis study was conducted on mice to investigate how local perfusion of COA-Cl affects dopamine (DA) and its metabolites in the dorsal striatum.
- Perfusion with COA-Cl at concentrations of 0.1 and 0.5 mM significantly increased extracellular levels of DA, 3-methoxytyramine (3-MT), and homovanillic acid (HVA), indicating a dose-dependent effect, while 0.05 mM had no significant impact.
- The addition of the MAO inhibitor clorgyline revealed that COA-Cl enhances DA metabolism, suggesting it influences dopamine levels through increased DA release and/or activation of MAO in the brain.
Article Synopsis
- A woman in her thirties was found dead, and an autopsy showed no signs of injury or natural disease, prompting a toxicological investigation.
- Toxicology tests revealed high levels of fluvoxamine, levomepromazine, and trihexyphenidyl, with fluvoxamine's toxicity likely enhanced by levomepromazine, which inhibits its metabolism.
- The combination of these drugs could increase the risk of seizures and other serious symptoms, leading to the conclusion that her death was caused by dangerous interactions between multiple medications.
Purpose: We have investigated the absorption dynamics of petroleum fuel components from the analytical results of autopsy samples.
Methods: Post-mortem samples of the severely burned case, including femoral blood, intratracheal contents (mucus) and intratracheal gas-phase samples were collected, and analysed by gas chromatography-mass spectrometer with head-space solid-phase microextraction.
Results: The composition of flammable substances in the tracheal gas phase differed slightly from that in mucus.
Article Synopsis
- - A man in his forties was found dead at a friend's house, with toxicological analysis revealing fatal levels of caffeine and other drugs commonly found in an over-the-counter cough medicine called BRON, which is sold in Japan.
- - The analysis showed significant concentrations of caffeine, chlorpheniramine, dihydrocodeine, and methylephedrine, with caffeine being classified as a methylxanthine and primarily metabolized by cytochrome P450 (CYP)1A2, which can be inhibited by fluvoxamine.
- - The study concluded that his death resulted from an overdose of BRON, highlighting the need to consider drug interactions, as fluvoxamine's inhibition of caffeine metabolism likely increased his caffeine
A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.
View Article and Find Full Text PDFWe present a fatal case of pilsicainide poisoning. Quantitative toxicological analysis revealed that the concentrations of pilsicainide in femoral blood and urine samples were 17.5 μg/mL and 136.
View Article and Find Full Text PDFCOA-Cl, a novel adenosine-like nucleic acid analog, has recently been shown to exert neuroprotective effects and to increase dopamine levels both in vivo and in vitro. Therefore, we hypothesized that COA-Cl could protect dopaminergic neurons against toxic insults. Thus, the present study aimed to investigate the protective effects of COA-Cl against hydrogen peroxide (HO)- and 6-hydroxydopamine (6-OHDA)-induced toxicity in PC12 cells and to elucidate the possible mechanisms.
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