Publications by authors named "Selina Sohre"
Article Synopsis
- - Cysteine, a well-studied amino acid, is less common in certain biological areas, leading to a "cysteine anomaly" that has puzzled researchers, especially in aerobic organisms.
- - The study examines how lipophilic thiols, like dodecylthiol, can rapidly form thiyl radicals in hydrophobic environments, which could explain the cysteine anomaly by inducing stress responses in cells without directly causing lipid peroxidation.
- - Findings suggest that lipophilic thiols act as biological cytotoxins, promoting oxidative damage specifically through unique interactions not seen with other compounds, influencing the structural biology of life.
Purpose: Only a fraction of the currently established low-molecular weight antioxidants exhibit cytoprotective activity in living cells, which is considered a prerequisite for their potential clinical usefulness in Parkinson's disease or stroke. Post hoc structure-activity relationship analyses have predicted that increased lipophilicity and enhanced radical stabilization could contribute to such cytoprotective activity.
Methods: We have synthesized a series of novel phenothiazine-type antioxidants exhibiting systematic variation in their lipophilicity and radical stabilization.