Publications by authors named "Selina M Yogeshwar"
Article Synopsis
- Anti-IgLON5 disease is an autoimmune encephalitis that often goes undiagnosed, characterized by diverse symptoms affecting sleep, movement, and other functions.
- A study of 87 patients revealed strong associations between the disease and specific HLA-DQ genotypes, indicating a genetic predisposition to its development.
- Experiments showed that modified IgLON5 peptides preferentially bind to these HLA-DQ receptors, suggesting that this interaction could trigger T-cell responses involved in initiating the disease.
Proc Natl Acad Sci U S A
September 2023
Article Synopsis
- Scientists studied over 176,000 people to see how certain genes might protect against Parkinson's disease (PD) and Alzheimer's disease (AD).
- They found that specific types of a gene called HLA could help reduce the risk of these diseases and lower harmful proteins in the brain.
- This suggests that our immune system might help protect us from PD and AD, which could lead to new treatments in the future.
Article Synopsis
- * The study analyzed over 6,000 NT1 cases and identified new genetic associations (e.g., CD207, NAB1) tied to immune response, particularly involving T cells.
- * Results suggest that genetic factors in NT1 also relate to other autoimmune diseases, indicating a shared immune mechanism influenced by environmental factors like infections and vaccinations.
