Publications by authors named "Selina J Hein"
Article Synopsis
- Elevated interleukin-6 (IL-6) levels are linked to worse outcomes in patients with cardiac ATTR amyloidosis (ATTR-CM) and are more pronounced in those with more severe clinical presentations.
- The study involved measuring IL-6 levels in 106 ATTR-CM patients, along with asymptomatic carriers and healthy controls, finding significant differences in levels particularly between wild-type patients and healthy controls.
- While high IL-6 levels are associated with poor outcomes, it did not enhance risk prediction beyond existing established prognostic factors.
Translucent zebrafish larvae represent an established model to analyze genetics of cardiac development and human cardiac disease. More recently adult zebrafish are utilized to evaluate mechanisms of cardiac regeneration and by benefiting from recent genome editing technologies, including TALEN and CRISPR, adult zebrafish are emerging as a valuable in vivo model to evaluate novel disease genes and specifically validate disease causing mutations and their underlying pathomechanisms. However, methods to sensitively and non-invasively assess cardiac morphology and performance in adult zebrafish are still limited.
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