Publications by authors named "Selina Gurri"
Article Synopsis
- Chloride channel accessory 2 (CLCA2) is a protein that helps keratinocytes stick together and survive when faced with high salt levels, and it's important for their function in the nucleus.
- The study reveals that CLCA2 is transported to the nucleus through extracellular vesicles, where it helps regulate cell behavior by interacting with β-catenin, influencing the expression of specific genes.
- Importantly, RNA binding protein 3 works alongside nuclear CLCA2, indicating a significant role for these proteins in skin health and their potential interaction during stress responses.
Epithelial skin cancers are extremely common, but the mechanisms underlying their malignant progression are still poorly defined. Here, we identify the NRF3 transcription factor as a tumor suppressor in the skin. NRF3 protein expression is strongly downregulated or even absent in invasively growing cancer cells of patients with basal and squamous cell carcinomas (BCC and SCC).
View Article and Find Full Text PDFVertebrate lonesome kinase (VLK) is the only known secreted tyrosine kinase and responsible for the phosphorylation of a broad range of secretory pathway-resident and extracellular matrix proteins. However, its cell-type specific functions in vivo are still largely unknown. Therefore, we generated mice lacking the VLK gene (protein kinase domain containing, cytoplasmic (Pkdcc)) in mesenchymal cells.
View Article and Find Full Text PDFFGFs and their high-affinity receptors (FGFRs) play key roles in development, tissue repair, and disease. Because FGFRs bind overlapping sets of ligands, their individual functions cannot be determined using ligand stimulation. Here, we generated a light-activated FGFR2 variant (OptoR2) to selectively activate signaling by the major FGFR in keratinocytes.
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