Publications by authors named "Selina Gies"
During cervical carcinogenesis, T-helper (Th)-17 cells accumulate in the peripheral blood and tumor tissues of cancer patients. We previously demonstrated that Th17 cells are associated with therapy resistance as well as cervical cancer metastases and relapse; however, the underlying Th17-driven mechanisms are not fully understood. Here, using microarrays, we found that Th17 cells induced an epithelial-to-mesenchymal transition (EMT) phenotype of cervical cancer cells and promoted migration and invasion of 2D cultures and 3D spheroids via induction of microRNA miR-142-5p.
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- Scientists are studying how treating vulvar cancer with radiation and chemotherapy affects the immune system, especially a type of immune cell called T cells.
- They found that after treatment, some T cells that help fight cancer (like IL-17-producing cells) increased, while others that are really good at killing cancer (Th1 and perforin-producing cells) decreased.
- This research might help understand why some patients have different experiences with cancer and suggests looking at certain proteins (PD-1 and IL-17) could be helpful for new treatments.