Publications by authors named "Selin Turan"
Purpose: Multiple sclerosis (MS) patients whose first demyelinating event is optic neuritis have been claimed to display a milder disease course and reduced physical disability. Our aim was to investigate the impact of the clinical features of the first clinical episode on cognitive disability and sleep dysfunction in MS.
Methods: A total of 26 (10 with optic neuritis as the first clinical event) MS patients were recruited.
Background: Anti-neuronal autoimmunity may cause cognitive impairment that meets the criteria for dementia. Objective. Our aim was to detect the incidence and clinical features of autoimmune encephalitis imitating clinical findings of primary dementia disorders and to delineate the validity of anti-neuronal antibody screening in dementia patients.
View Article and Find Full Text PDFMyasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness associated with acetylcholine receptor (AChR), muscle-specific receptor kinase (MuSK) or low-density lipoprotein receptor-related protein 4 (LRP4)-antibodies. MuSK-antibodies are predominantly of the non-complement fixing IgG4 isotype. The MuSK associated experimental autoimmune myasthenia gravis (EAMG) model was established in mice to investigate immunoglobulin (Ig) and cytokine responses related with MuSK immunity.
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- - A study aimed to find a biomarker for multiple sclerosis (MS) that indicates potential relapse and disability, focusing on SWAP-70 antibodies in patients with relapsing-remitting MS (RRMS).
- - Researchers tested serum samples from 26 RRMS patients, finding high levels of SWAP-70 antibodies during attacks compared to remission, and noted a significant link between these antibody levels and various disability indicators.
- - The findings suggest that SWAP-70 antibodies could serve as useful biomarkers for MS prediction, but more research is needed to understand their role in disease processes.
Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.
View Article and Find Full Text PDFAutoimmune encephalitis associated with glutamic acid decarboxylase antibodies (GAD-Ab) often presents with treatment-resistant partial seizures, as well as other central nervous system symptoms. In contrast to several other well-characterized autoantibodies, GAD-Ab has very rarely been associated with status epilepticus. We report a 63-year-old woman initially admitted with somnolence and psychiatric findings.
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- The study investigated the presence of anti-neuronal antibodies in ALS patients to determine if they could be mistaken for autoimmune encephalitis.
- Only a small percentage (5.7%) of ALS patients showed ganglioside antibodies, while onconeural and ion channel antibodies were absent.
- Although routine testing for onconeural and ion channel antibodies in ALS is unnecessary, some ALS patients exhibited unknown anti-neuronal antibodies, highlighting the need for further research.