Dual-radiotracer translational SPECT neuroimaging. Comparison of three methods for the simultaneous brain imaging of D and 5-HT receptors.

Purpose: SPECT imaging with two radiotracers at the same time is feasible if two different radioisotopes are employed, given their distinct energy emission spectra. In the case of I and I, dual SPECT imaging is not straightforward: I emits photons at a principal energy emission spectrum of 143.1-179.

A single-scan protocol for absolute D receptor quantification with [I]IBZM SPECT.

Purpose: Molecular imaging of the D receptor is widely used in neuropsychiatric research. Non-displaceable binding potential (BP) is a very popular quantitative index, defined as the product of the receptor concentration (B) and the radiotracer affinity for the receptor (1/appK). As the appK is influenced by parameters such as the endogenous neurotransmitter dynamics, it often constitutes a confounding factor in research studies.