A proposal for minimum detectable compartment in MIRD dosimetry modelling.

The accuracy of radiation dose estimates from radiopharmaceutical administrations has recently become more important for three main reasons: (i) clinical providers are demanding more information on diagnostic procedures; (ii) regulatory groups are scrutinizing dosimetry for research subjects; and (iii) accurate organ doses are crucial in therapeutic administrations. These dose estimates are a sensitive function of the residence times. Because most clinical data acquisition protocols are limited to the first 24 h after dose administration, the area under the remainder of the time-activity curve (TAC) must be estimated.

A portable survey meter method for locating and quantifying removable contamination after 131I therapies.

Identifying 131I surface contamination and decontaminating the removable fraction from rooms where patients have received iodine therapies is a common task at many hospitals. The current regulatory preferred method for this task is wipe testing for removable contamination. The purpose of this paper is to evaluate the suitability of a sensitive survey meter for this task.

Biodistribution and dosimetry of iodine-123-IBF: a potent radioligand for imaging the D2 dopamine receptor.

Iodine-123-labeled iodo-benzofuran (IBF) is a potent D2 dopamine receptor antagonist that has been developed as a potential SPECT imaging agent. This report documents its biodistribution and radiation dosimetry in seven healthy humans. Approximately 100 MBq of IBF were administered to each volunteer.

The dosimetry of iodine-123-labeled TISCH: a SPECT imaging agent for the D1 dopamine receptor.

TISCH is an iodinated D1 specific dopamine receptor antagonist that may be useful as a SPECT imaging agent. This report documents its pharmacological safety in animals and its radiation dosimetry in humans. The dose of radiation that 123I-TISCH delivered to seven healthy subjects was estimated with the absorbed fraction technique.

Averaging error in NMR slice profile measurements.

Slice thickness is a primary operational parameter in the evaluation of the performance of an MRI system with regard to providing accurate imaging of a slice of tissue. Of the various methods that have been utilized to evaluate slice thickness, a continuous high-signal ramp has gained the most support as the method of choice. However, problems with the accuracy of the measurement method have been associated with the finite thickness of the ramp.